gut health
ABO

What Does Blood Type Have to Do with Gastritis? (ABO)

Written by Jasmine Foster, BSc, BEd on May 18th, 2020
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ABO is the major gene that determines blood group. Can it affect your immune response and susceptibility to stomach inflammation? Read on to find out.

What is ABO?

ABO is the major gene that determines blood type in humans. Several variants combine to determine blood type, the major ones being rs8176719, rs8176746, and rs8176747. Using these SNPs, researchers can identify whether someone has an A, B, AB, or O blood type [R].

ABO blood groups may produce resistance or susceptibility to various diseases and disorders. For example, people with an O blood type are somewhat protected from many infections and types of cancer compared to people with type A, B, or AB blood types [R, R, R, R].

Generally speaking, O blood types appear to be linked with better health outcomes than B, and B blood types better than A, though there are exceptions to this rule [R, R].

ABO & Gut Inflammation

The O blood types (O+ and O-) appear to produce more intense (and often more effective) responses to pathogenic bacteria like H. pylori in the gut [R].

The white blood cells of people with O blood types are more likely to move into the gut lining and produce inflammatory signals in response to H. pylori. Researchers have pointed to this phenomenon as the reason why O blood types are associated with lower rates of infection, but higher rates of gastritis and ulcers [R].

The reason for the difference in white blood cell behavior is not completely certain. However, some research suggests that the A, B, and O blood antigens may change the way white blood cells bind to potential threats; type O leukocytes, for example, bound to pieces of H. pylori much more effectively than type A or type B leukocytes [R].

People in the O blood group may have white blood cells that can bind more effectively to H. pylori and produce a more intense inflammatory response.

What is Gastritis?

Gastritis is a condition characterized by inflammation of the stomach lining. It may be acute (sudden and short-term) or chronic (developing slowly and long-term). One type of gastritis called erosive gastritis breaks down the lining of the stomach, sometimes leading to ulcers. Another type, called atrophic gastritis, causes a loss of glandular tissue in the lining of the stomach, often replaced by scar tissue; this type is often caused by an autoimmune reaction [R, R].

Gastritis can have a number of causes. These include H. pylori infection, long-term NSAID use, alcohol abuse, cocaine use, or autoimmune disease. Severe injuries, burns, sepsis, and some drugs can also cause acute erosive gastritis [R]

H. pylori is the most common cause of gastritis, and about 35% of the US population is infected with this bacteria [R].

ABO Variants & Gastritis

At least two studies have found that people with a genetic marker for type ‘B’ blood have lower rates of gastritis in response to H. pylori infection. The ‘T’ allele of rs8176746 (which signifies B group blood) is associated with reduced rates of gastritis, while the ‘G’ allele of rs8176746 (which signifies A group blood) is associated with increased rates of gastritis [R, R].

When compared to O type blood, B type blood may reduce the incidence of gastritis and A type blood may increase the incidence of gastritis [R, R, R].

Inheritance of blood groups is surprisingly complex, relying on the interaction of rs8176746, rs8176747, and rs8176719 (a deletion mutation that signifies O type). If you know your blood type, it is more reliable to refer to that rather than to infer based on these SNPs.

In summary:

  • Type B: Lowest likelihood of gastritis
  • Type O: Medium likelihood of gastritis
  • Type A: Highest likelihood of gastritis

The variant that indicates B blood group (rs8176746-T) is associated with lower rates of gastritis, while the variant that indicates A blood group (rs8176746-G) is associated with higher rates of gastritis.

Your ABO Results for Gastritis

SNP Table

variant genotype frequency risk allele
rs8176746
rs8176747

 

SNP Summary and Table

ABO rs8176746

  • ‘G’ = Associated with lack of B blood group and possibly increased rates of gastritis
  • ‘T’ = Associated with presence of B blood group and possibly reduced rates of gastritis
  • Only about 27% of all people worldwide have at least one copy of the ‘T’ allele.
  • The ‘T’ allele (and the B blood group) are significantly more common in South Asian populations (40%) and significantly less common in European (16%) and American (9%) populations.

ABO rs8176747

  • ‘G’ = Associated with lack of A blood group and possibly reduced rates of gastritis
  • ‘C’ = Associated with presence of A blood group and possibly increased rates of gastritis
  • Only about 27% of all people worldwide have at least one copy of the ‘G’ allele.
  • The distribution of alleles at rs8176747 is very similar to that of rs8176746.

Genotypes at these two SNPs and a deletion mutation, rs8176719, combine to determine blood type. If you want to do a deeper dive, here’s a quick guide to get started:

  • rs8176746-GG + rs8176747-CC without the deletion at rs8176719 produces type A blood
  • rs8176746-GT + rs8176747-CG without the deletion at rs8176719 produces type AB blood
  • rs8176746-TT + rs8176747-GG without the deletion at rs8176719 produces type B blood
  • One copy of the deletion at rs8176719 replaces one allele with an ‘O’ allele, producing either type A or type B blood (refer to other two SNPs).
  • Two copies of the deletion at rs8176719 replaces both alleles with ‘O’ alleles, producing type O blood.

 

Recommendations

Diet

A Note on Blood Group Diets

Some people believe that certain diets are better for different blood types. The so-called “blood type diet” or “blood group diet” was popularized by P. J. D’Adamo in his 1996 book Eat Right For Your Type. However, while these specialized diets have been associated with positive health outcomes, their benefits were not specific to any single blood type, and none has been found to decrease the incidence of gastritis [R].

Eliminate Proinflammatory Foods

Certain dietary components may trigger an inflammatory response in people who are predisposed to chronic inflammation [R, R].

Doctors may recommend avoiding certain foods that may increase the intensity of the immune response and aggravate gastric inflammation. It is important to follow any dietary restrictions your doctor recommends; if you do not receive dietary guidance, you may want to ask them about the foods on this list:

  • Soft drinks: soft drinks and other carbonated beverages are also believed to stimulate acid secretion and are therefore often on the list of things to avoid if you have gastritis [R, R].
  • Sweets & simple sugars: some evidence suggests that simple carbohydrates may stimulate the production of stomach acid and worsen outcomes in gastric inflammation [R].
  • Very fatty food: some doctors may advise against fatty meats and cheeses, and you may be advised to cut deep fried foods entirely [R].

Certain foods may trigger inflammation in people who are predisposed to gastritis; cutting these out, or at least reducing intake, may improve outcomes.

Fermented Foods

Certain fermented beverages – especially wine, beer, and fermented milk – have produced promising clinical results in supporting H. pylori and gastritis treatment, likely because they are a natural source of probiotic bacteria [R, R].

In a cross-sectional study of over 10,000 people in England, moderate consumption of wine and beer was found to be somewhat protective against H. pylori infection. The authors suggested that moderate wine and beer consumption could produce an environment in the stomach that is hostile to H. pylori, thereby making it easier to eradicate the bacteria [R].

However, another study found that alcohol consumption was positively associated with H. pylori infection, suggesting that a component of wine and beer other than alcohol could be responsible for their apparent benefit [R].

Fermented dairy products such as yogurt and kefir were also found to be protective against H. pylori infection. Furthermore, the addition of yogurt to conventional therapy improved eradication rates in one trial of 347 patients [R, R, R].

Some authors have suggested that other fermented foods could protect against H. pylori, but that our poor understanding of specific ethnic fermented foods around the world is a major obstacle to using them in a clinical setting [R].

Fermented foods and drinks are a natural source of probiotic bacteria that may help outcompete H. pylori and prevent gastritis.

Broccoli Sprouts & Brassica Vegetables

Sulforaphane, a compound found in broccoli and broccoli sprouts, may inhibit the growth of H. pylori and thereby prevent H. pylori-associated gastritis [R].

Researchers have suggested that sulforaphane may protect the mucosal membranes of the stomach, which may lead to reduced inflammation [R]. Improved mucosal membrane health may also make it more difficult for H. pylori to colonize the stomach effectively, explaining the reduced rate of colonization found in some studies [R].

In asymptomatic patients with confirmed H. pylori infection, eating 70 g/day of broccoli sprouts resulted in a significant decrease of colonization intensity [R].

Another study also reported a loss of H. pylori colonization following broccoli sprout treatment in four out of nine test subjects [R].

In type 2 diabetic patients infected with H. pylori, broccoli sprouts powder in addition to standard triple therapy showed a considerable improvement in H. pylori eradication, and also showed improved heart health in subjects [R].

In mice, H. pylori infections were effectively eliminated by sulforaphane injections [R].

However, a small study with H. pylori-colonized humans in Japan was unable to demonstrate an improvement when supplementing broccoli sprouts [R].

Other brassica vegetables (cauliflower, swede, headed cabbage, turnip, radish) also contain compounds in the same family as sulforaphane, collectively called isothiocyanates [R].

Sulforaphane is a compound found in broccoli sprouts and other brassica vegetables which help eradicate H. pylori and prevent gastritis.

Supplements

Probiotics

A healthy gut flora is in constant communication with our immune systems, suppressing inflammation and sending signals that it is not a threat. Certain probiotic supplements (Lactobacillus and Bifidobacterium species) may help soothe the immune response and reduce the excess information associated with some blood groups [R].

Probiotic supplements are a popular way to support conventional therapies for digestive ailments. In gastritis, they may only be helpful in cases where H. pylori infection is a concern [R, R].

According to some researchers, probiotic bacteria compete with H. pylori in the digestive tract, possibly making this harmful infection more susceptible to antibiotics and other drugs [R, R, R].

Some probiotic bacteria may help soothe the immune response and help manage gastritis.

CoQ10

Coenzyme Q10 (CoQ10) is an important compound found in every cell in the body. It is a type of coenzyme, which means that it helps other enzymes work more effectively. CoQ10 is mainly located in the membrane of mitochondria, where it is used to make energy [R].

The combination of standard antibiotic triple therapy with CoQ10 had a positive effect on the stomach lining inflammation and decreased oxidative stress in patients with H. pylori-associated chronic gastritis [R].

Author photo
Jasmine Foster
BSc, BEd

Jasmine received her BS from McGill University and her BEd from Vancouver Island University.

Jasmine loves helping people understand their brains and bodies, a passion that grew out of her dual background in biology and education. From the chem lab to the classroom, everyone has the right to learn and make informed decisions about their health.

Disclaimer

The information on this website has not been evaluated by the Food & Drug Administration or any other official medical body. This information is presented for educational purposes only, and may not be used to diagnose or treat any illness or disease.

Also keep in mind that the “Risk Score” presented in this post is based only on a select number of SNPs, and therefore only represents a small portion of your total risk as an individual. Furthermore, these analyses are based primarily on associational studies, which do not necessarily imply causation. Finally, many other (non-genetic) factors can also play a significant role in the development of a disease or health condition — therefore, carrying any of the risk-associated genotypes discussed in this post does not necessarily mean you are at increased risk of developing a major health condition.

Always consult your doctor before acting on any information or recommendations discussed in this post — especially if you are pregnant, nursing, taking medication, or have been officially diagnosed with a medical condition.

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