rs7442295 is a SNP in the SLC2A9 gene. It is significantly associated with urate concentrations and self-reported gout [RR1].

rs7442295 was shown to have gender-specific effects on uric acid concentrations, resulting in a greater reduction in women (−0.352 to −0.880 mg/dl) than in men (−0.128 to −0.428 mg/dl) [R]. 

The rare allele ''G'' has a negative additive effect of 0.42 mg/dl on serum uric acid levels (p = 2.57 × 10−12) [RR1].  

Each copy of the minor allele ''G'' decreased uric acid levels by 0.30-0.38 mg/dL (p values: 10(-20)-10(-36)) [R].

Among women, the presence of the minor allele ''G'' was related to a small increase in Parkinson's disease (PD) risk (OR = 1.48) [R]. 

 

rs7442295

Parent Gene: SLC2A9

Importance: 4
Less common allele: G = 26%
More common allele: A = 74%
My Genotype: Log In
Risk Allele: C, A

Disease/Trait: Urate Measurement

The C allele of rs7442295 is reported to be associated with Urate Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Urate levels.

Disease/Trait: Urate Measurement

The A allele of rs7442295 is reported to be associated with Urate Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Urate levels.