rs7442295 is a SNP in the SLC2A9 gene. It is significantly associated with urate concentrations and self-reported gout [R, R1].
rs7442295 was shown to have gender-specific effects on
concentrations, resulting in a greater reduction in women (−0.352 to −0.880 mg/dl) than in men (−0.128 to −0.428 mg/dl) [R].
The rare allele ''G'' has a negative additive effect of 0.42 mg/dl on serum
levels (p = 2.57 × 10−12) [R, R1].
Each copy of the minor allele ''G'' decreased
levels by 0.30-0.38 mg/dL (p values: 10(-20)-10(-36)) [R].
Among women, the presence of the minor allele ''G'' was related to a small increase in Parkinson's disease (PD) risk (OR = 1.48) [R].