Mechanism:

  • The "A" allele results in 1.4X increased GSK3B expression (R).

AA is associated with:

  • Higher risk for Alzheimer's in a meta-analyses (OR=1.37) (R)
  • Higher risk for Depression (OR=1.24) (R)
  • Has more white matter in bipolar patients in various brain regions (involving interhemispheric, limbic, and large frontal, parietal, and fronto-occipital connections) (R)
  • Does better with SSRIs (AA only, more likely to get into remission from depression) (R).

AG is associated with:

  • Higher risk for Alzheimer's in a meta-analyses (OR=1.37) (R)
  • Higher risk for Depression (OR=1.24) (R)
  • Insomnia (R).
  • Increased Tau levels (R)

GG is associated with:

  • Is associated with insomnia (GG, GA) (R).
  • Increased Tau levels (R).
  • May have more difficulty in neurocognition (decreased P300 amplitude) (GG)

rs334558

Parent Gene: GSK3B

Importance: 5
Less common allele: A = 40%
More common allele: G = 60%
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