Mechanism:

• The "A" allele results in 1.4X increased GSK3B expression (R).

AA is associated with:

• Higher risk for Alzheimer's in a meta-analyses (OR=1.37) (R)
• Higher risk for Depression (OR=1.24) (R)
• Has more white matter in bipolar patients in various brain regions (involving interhemispheric, limbic, and large frontal, parietal, and fronto-occipital connections) (R)
• Does better with SSRIs (AA only, more likely to get into remission from depression) (R).

AG is associated with:

• Higher risk for Alzheimer's in a meta-analyses (OR=1.37) (R)
• Higher risk for Depression (OR=1.24) (R)
• Insomnia (R).
• Increased Tau levels (R)

GG is associated with:

• Is associated with insomnia (GG, GA) (R).
• Increased Tau levels (R).
• May have more difficulty in neurocognition (decreased P300 amplitude) (GG)