rs242941 is a SNP in the CRHR1 gene. It has been associated with a greater antidepressant treatment response [R].

After a 12-week treatment, the response to inhaled corticosteroids was significantly higher in patients with wild-type CC genotype than in AC heterozygotes (P = 0.003) for Chronic obstructive pulmonary disease (COPD) [R].

The ''C'' allele was associated with a 70% greater reduction in Hamilton rating scales for anxiety (HAM-A) scores (63.1plusminus4.5% in homozygous and 37.1plusminus6.9% in heterozygous, P=0.002) and 31% greater reduction in Hamilton rating scales for depression (HAM-D) scores after treatment (67.3plusminus4.3% in homozygous and 51.2plusminus6.0% in heterozygous, P=0.03) [R1, R2].

The minor allele ''A'' was significantly associated with poor lung function response (OR=1.9). Half of all subjects with two copies of the minor allele are poor lung function responders versus only 20% of subjects with two copies of the major allele [R].

 

 

 

rs242941

Parent Gene: CRHR1

Importance: 2
Less common allele: A = 32%
More common allele: C = 68%
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