The Minor "G" allele is associated with:

  •  Greater benefit from aspirin used to prevent diseases (R).
  • Carriers of G allele might derive greater benefits from aspirin use in primary prevention (R).
  • Higher risk for end-stage Osteoarthritis (primary, bilateral, hip and knee) (R).

The Major "C" allele is associated with: 

  • The C allele was associated with a lower risk of end-stage Osteoarthritis (primary, bilateral, hip and knee) (R).
  • The C allele was associated with lower risks of Myocardial Infarction and stroke in an Italian population (R).
  • In Italy, GC appeared at lower risk of cerebrovascular ischemia (R). 
  •  Individuals (Pima Indians) with the variant CC had a 30% higher risk of type 2 diabetes. This may effect chronic inflammation (OR=1.6 per copy of C allele; P=0.01) (R).
  • The C allele was also associated with worse arteries (lower carotid IMT) in a subgroup of people with high cholesterol (R).
  • The C allele was reported to be associated with higher risk of stroke in African Americans (R).  
 

rs20417

Parent Gene: COX2

Importance: 3
Less common allele: G = 20%
More common allele: C = 80%
My Genotype: Log In