The Minor "A" allele is associated with:

  • Increased BMI, hip circumference, total weight and waist circumference (R).
  • Increased risk of obesity (found in danish population) (R).
  • Increased risk of obesity in individuals with polycystic ovarian syndrome (R).
  • Increased insulin resistance in a European population (R).
  • Increased risk of Type 2 diabetes in Japanese populations (R) and Chinese population (R). 
  • Increased risk of Metabolic syndrome (R).

The Major "G" allele is associated with:

  • Higher metabolism of fat-proteins and higher total cholesterol levels after eating in normal-weight Caucasians (R).

This SNP is associated with (unknown which alleles):

  • Increased risk of Obesity (R) (R)
  • Increased insulin levels in overweight and obese children and adolescents (R)
  • Increased weight, BMI, and waist circumference in Indian children (R)
  • Increased BMI in children (R)
  • Increased risk of Type 2 diabetes in Han Chinese populations (R)

rs12970134

Parent Gene: MC4R

Importance: 5
Less common allele: A = 21%
More common allele: G = 79%
My Genotype: Log In
Risk Allele: A, A, A, A

Disease/Trait: Waist Circumference

The A allele of rs12970134 is reported to be associated with Waist Circumference (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Waist circumference and related phenotypes (waist circumference).

Disease/Trait: Type Ii Diabetes Mellitus

The A allele of rs12970134 is reported to be associated with Type Ii Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Type 2 diabetes.

Disease/Trait: Body Weight

The A allele of rs12970134 is reported to be associated with Body Weight (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Weight.

Disease/Trait: Body Mass Index

The A allele of rs12970134 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index.