- Non-functional CYP2D6 protein causes low levels of the protein (C).
- Functional CYP2D6 protein causes normal levels of the protein (G).
The Minor "C" allele is associated with:
Decreased risk for cancer, based on a meta-analysis of 43 studies (CC) [R]
The Major "G" allele is associated with:
A possible increased risk of developing cancer in heterozygotes (CG), based on a meta-analysis of 43 studies [R]
Lower rate of metabolism of the antimalarial drug Hydroxychloroquine, in patients being treated for Systemic Lupus Erythematosus. [R] Drug metabolism could be closely related to treatment response. [R]
This SNP is associated with (unknown which alleles):
Susceptibility to chronic Benzene Poisoning, particularly in a combined effect with CYP1A1 rs4646903 and CYPD62 rs1065852 [R]