Mechanism:
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T = Decreased transcription of the catalase gene [R]
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C = Increased transcription of the catalase gene [R]
The Minor "T" allele is associated with:
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Decreased acoustic neuroma (noncancerous tumor in nerve leading from ear to brain) risk in non-Hispanic whites [R]
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Increased chance of cardiac damage after exposure to anthracyclines [R]
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An increased risk of type-2 diabetes [R]
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Increased risk of myocardial infarction following cardiac surgery [R]
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Increased risk of death from rectal cancer following radiotherapy [R]
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Increased visual acuity [R]
The Major "C" allele is associated with:
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Increased acoustic neuroma (noncancerous tumor in nerve leading from ear to brain) risk in non-Hispanic whites [R]
-
A decreased risk of type-2 diabetes [R]
-
Decreased risk of myocardial infarction following cardiac surgery [R]
-
Decreaseed risk of death from rectal cancer following radiotherapy [R]
-
Decreased visual acuity [R]
This SNP is associated with (unknown which alleles):
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Decreased susceptibility to the effects of particulate air pollution [R]
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Increased risk of breast cancer [R]
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Increase susceptibility to malaria infection in the Indian population [R]
Increase clinical expression of Wilson’s Disease [R]