Mechanism:

• T = Decreased transcription of the catalase gene [R]

• C = Increased transcription of the catalase gene [R]

The Minor "T" allele is associated with:

• Decreased acoustic neuroma (noncancerous tumor in nerve leading from ear to brain) risk in non-Hispanic whites [R]

• Increased chance of cardiac damage after exposure to anthracyclines [R]

• An increased risk of type-2 diabetes [R]

• Increased risk of myocardial infarction following cardiac surgery [R]

• Increased risk of death from rectal cancer following radiotherapy [R]

• Increased visual acuity [R]

The Major "C" allele is associated with:

• Increased acoustic neuroma (noncancerous tumor in nerve leading from ear to brain) risk in non-Hispanic whites [R]

• A decreased risk of type-2 diabetes [R]

• Decreased risk of myocardial infarction following cardiac surgery [R]

• Decreaseed risk of death from rectal cancer following radiotherapy [R]

• Decreased visual acuity [R]

This SNP is associated with (unknown  which alleles):

• Decreased susceptibility to the effects of particulate air pollution [R]

• Increased risk of breast cancer [R]

• Increase susceptibility to malaria infection in the Indian population [R]

Increase clinical expression of Wilson’s Disease [R]