The Function of TBX1
Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries.
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Protein names
Recommended name:
T-box transcription factor TBX1Alternative name(s):
T-box protein 1Testis-specific T-box protein
- RS2238776 (TBX1) ??
- RS41297816 (TBX1) ??
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Top Gene-Substance Interactions
TBX1 Interacts with These Diseases
| Disease | Score |
Substances That Increase TBX1
| Substances | Interaction | Organism | Category |
Substances That Decrease TBX1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Dna Binding
- Protein Dimerization Activity
- Protein Homodimerization Activity
- Sequence-Specific Dna Binding
Biological Processes:
- Angiogenesis
- Anterior/Posterior Pattern Specification
- Aorta Morphogenesis
- Artery Morphogenesis
- Blood Vessel Development
- Blood Vessel Morphogenesis
- Cell Fate Specification
- Cell Proliferation
- Cellular Response To Fibroblast Growth Factor Stimulus
- Cellular Response To Retinoic Acid
- Cochlea Morphogenesis
- Coronary Artery Morphogenesis
- Determination Of Left/Right Symmetry
- Ear Morphogenesis
- Embryonic Cranial Skeleton Morphogenesis
- Embryonic Viscerocranium Morphogenesis
- Enamel Mineralization
- Epithelial Cell Differentiation
- Face Morphogenesis
- Heart Development
- Heart Morphogenesis
- Inner Ear Morphogenesis
- Lymph Vessel Development
- Mesenchymal Cell Apoptotic Process
- Mesoderm Development
- Middle Ear Morphogenesis
- Muscle Cell Fate Commitment
- Muscle Organ Development
- Muscle Organ Morphogenesis
- Muscle Tissue Morphogenesis
- Negative Regulation Of Cell Differentiation
- Negative Regulation Of Mesenchymal Cell Apoptotic Process
- Neural Crest Cell Migration
- Odontogenesis Of Dentin-Containing Tooth
- Outer Ear Morphogenesis
- Outflow Tract Morphogenesis
- Outflow Tract Septum Morphogenesis
- Parathyroid Gland Development
- Pattern Specification Process
- Pharyngeal System Development
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Epithelial Cell Proliferation
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Mesenchymal Cell Proliferation
- Positive Regulation Of Protein Phosphorylation
- Positive Regulation Of Tongue Muscle Cell Differentiation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Organ Morphogenesis
- Regulation Of Transcription From Rna Polymerase Ii Promoter
- Retinoic Acid Receptor Signaling Pathway
- Semicircular Canal Morphogenesis
- Sensory Perception Of Sound
- Social Behavior
- Soft Palate Development
- Thymus Development
- Thyroid Gland Development
- Tongue Morphogenesis
- Transcription, Dna-Templated
- Vagus Nerve Morphogenesis