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  3. SQLE

SQLE (Squalene epoxidase)

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The Function of SQLE

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.

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Protein names

Recommended name:

Squalene monooxygenase

Short name:

SE

Alternative name(s):

Squalene epoxidase

SQLE SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13268726 (SQLE) ??

Top Gene-Substance Interactions

SQLE Interacts with These Diseases

Disease Score

Substances That Increase SQLE

Substances Interaction Organism Category

Substances That Decrease SQLE

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • C/EBPalpha
  • FAC1
  • Meis-1
  • E47
  • Meis-1b

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid biosynthesis

Molecular Function:

  • Flavin Adenine Dinucleotide Binding
  • Squalene Monooxygenase Activity

Biological Processes:

  • Cellular Aromatic Compound Metabolic Process
  • Cholesterol Biosynthetic Process
  • Cholesterol Metabolic Process
  • Response To Organic Substance
  • Sterol Biosynthetic Process

Drug Bank:

  • Butenafine
  • Naftifine
  • Terbinafine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SE| AS27_11185| AS28_00493| CB1_000444015| D623_10018150| GW7_03593| H920_18186| M959_00134| MDA_GLEAN10010556| N300_08465| N301_04731| N302_07460| N303_07790| N305_13267| N306_03206| N307_11175| N309_10844| N310_06046| N311_07385| N312_13649| N321_12105| N322_12544| N324_07374| N325_09082| N328_01652| N329_10950| N330_12340| N331_02351| N332_00396| N333_12178| N334_14303| N335_00914| N339_01041| N341_12567| PAL_GLEAN10021371| PANDA_009549| Squalene monooxygenase| Squalene monooxygenase-like protein| UY3_12612| Y1Q_020577| Y956_13122| Z169_11816| Zinc finger protein 572| sqle

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