Summary of SCD
The gene codes for an enzyme, stearoyl-CoA desaturase. It is an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid [R].
The Function of SCD
Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides.
Protein names
Recommended name:
Acyl-CoA desaturaseAlternative name(s):
Delta(9Delta-9 desaturase
Fatty acid desaturase
Stearoyl-CoA desaturase
hSCD1
- RS2234970 (SCD) ??
- RS3071 (SCD) ??
- RS508384 (SCD) ??
- RS7849 (SCD) ??
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Top Gene-Substance Interactions
SCD Interacts with These Diseases
| Disease | Score |
Substances That Increase SCD
| Substances | Interaction | Organism | Category |
Substances That Decrease SCD
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.
Gene Pathways:
Cofactor:
Expected to bind 2 Fe(2+) ions per subunit, instead of the Zn(2+) ions seen in the 3D-structure.
Molecular Function:
Biological Processes:
- Long-Chain Fatty Acid Biosynthetic Process
- Long-Chain Fatty-Acyl-Coa Biosynthetic Process
- Monounsaturated Fatty Acid Biosynthetic Process
- Unsaturated Fatty Acid Biosynthetic Process