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SCD (Stearoyl-CoA desaturase)

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Summary of SCD

The gene codes for an enzyme, stearoyl-CoA desaturase. It is an enzyme involved in fatty acid biosynthesis, primarily the synthesis of oleic acid [R].

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The Function of SCD

Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:15907797, PubMed:18765284). Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15907797, PubMed:18765284). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069). Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides.

Protein names

Recommended name:

Acyl-CoA desaturase

Alternative name(s):

Delta(9
Delta-9 desaturase
Fatty acid desaturase
Stearoyl-CoA desaturase
hSCD1

SCD SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2234970 (SCD) ??
  2. RS3071 (SCD) ??
  3. RS508384 (SCD) ??
  4. RS7849 (SCD) ??

Top Gene-Substance Interactions

SCD Interacts with These Diseases

Disease Score

Substances That Increase SCD

Substances Interaction Organism Category

Substances That Decrease SCD

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • IRF-1
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b

Tissue specificity:

Detected in fetal liver, lung and brain. Highly expressed in adult adipose tissue, and at lower levels in adult brain and lung.

Gene Pathways:

  • PPAR signaling pathway
  • Biosynthesis of unsaturated fatty acids

Cofactor:

Expected to bind 2 Fe(2+) ions per subunit, instead of the Zn(2+) ions seen in the 3D-structure.

Molecular Function:

  • Iron Ion Binding
  • Oxidoreductase Activity
  • Stearoyl-Coa 9-Desaturase Activity

Biological Processes:

  • Long-Chain Fatty Acid Biosynthetic Process
  • Long-Chain Fatty-Acyl-Coa Biosynthetic Process
  • Monounsaturated Fatty Acid Biosynthetic Process
  • Unsaturated Fatty Acid Biosynthetic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Acyl-CoA desaturase| fatty acid desaturase 1| delta-9-desaturase| A306_12449| ACOD| acyl-CoA desaturase 1| AS27_02561| AS28_05920| CB1_000642013| delta-9 desaturase| Delta(9)-desaturase| delta(9)-desaturase 1| EGK_19978| FADS5| Fatty acid desaturase| hSCD1| M959_03583| MDA_GLEAN10023399| MSTP008| N300_11768| N301_10689| N302_13445| N303_09233| N305_07131| N306_08216| N307_06099| N308_00291| N309_00813| N320_12547| N326_05527| N332_05111| N335_04557| N340_11332| PAL_GLEAN10018272| PANDA_013634| predicted protein of HQ0998| Scd1| SCDOS| sex combs distal| stearoyl-CoA desaturase 1| stearoyl-CoA desaturase 5| stearoyl-CoA desaturase (delta-9-desaturase)| stearoyl-CoA desaturase opposite strand| stearoyl coenzyme A desaturase| stearoyl-coenzyme A desaturase| stearoyl-Coenzyme A desaturase 1| steroyl-CoA desaturase 1| TREES_T100012313| UY3_18912| Y1Q_010606| Y956_01562| Z169_12769| scd

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