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  3. RXRG

RXRG (Retinoid X receptor gamma)

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Summary of RXRG

This gene encodes proteins that are nuclear receptors and are involved in mediating the antiproliferative effects of retinoic acid. It increases DNA binding and transcriptional function on their respective response elements (R).

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The Function of RXRG

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.

Protein names

Recommended name:

Retinoic acid receptor RXR-gamma

Alternative name(s):

Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma

RXRG SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10800098 (RXRG) ??
  2. RS1128977 (RXRG) ??
  3. RS2134095 (RXRG) ??
  4. RS2651860 (RXRG) ??
  5. RS283696 (RXRG) ??
  6. RS285480 (RXRG) ??
  7. RS466639 (RXRG) ??

Top Gene-Substance Interactions

RXRG Interacts with These Diseases

Disease Score

Fixes

FIX: Eat liver or supplement with retinol, Fish Oil/DHA, Relora : A source of Magnolol (Ref) and  Honokiol (Ref) Read: The Importance of Real Vitamin A (Retinol)

Substances That Increase RXRG

Substances Interaction Organism Category

Substances That Decrease RXRG

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPalpha

Gene Pathways:

  • Pathways in cancer
  • PPAR signaling pathway
  • Gene Expression
  • Adipocytokine signaling pathway
  • Thyroid cancer
  • Small cell lung cancer
  • Non-small cell lung cancer

Molecular Function:

  • 9-Cis Retinoic Acid Receptor Activity
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Steroid Hormone Receptor Activity
  • Zinc Ion Binding

Biological Processes:

  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Cellular Response To Chemical Stimulus
  • Protein Homotetramerization
  • Transcription Initiation From Rna Polymerase Ii Promoter

Drug Bank:

  • Bexarotene
  • Tretinoin
  • Adapalene
  • Acitretin
  • Alitretinoin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| retinoid X receptor, gamma| A306_13626| AS27_15736| AS28_09943| CB1_000237007| D623_10024336| EGK_01907| GW7_21147| H920_09465| I79_012760| M91_03940| M959_12552| N300_11959| N301_09674| N302_00503| N303_07922| N305_07595| N306_01385| N307_04713| N308_02224| N309_09346| N310_05259| N311_11958| N320_12641| N321_10360| N322_00442| N324_06369| N327_03005| N328_00695| N330_00623| N332_14524| N333_11883| N334_07215| N339_12519| N340_07428| N341_09701| Nr2b3| nuclear receptor subfamily 2 group B member 3| PAL_GLEAN10017882| PANDA_002085| retinoic acid receptor RXR-gamma| retinoic acid receptor RXR-gamma-like protein| retinoic X receptor gamma-1| rxrc| RXR-gamma| RXRGAMMA| RXR gamma-1| TREES_T100015692| xrxrg| Y1Q_024537| Y956_03436| Z169_13450| rxrg

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