Summary of RXRG
This gene encodes proteins that are nuclear receptors and are involved in mediating the antiproliferative effects of retinoic acid. It increases DNA binding and transcriptional function on their respective response elements (R).
The Function of RXRG
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.
Protein names
Recommended name:
Retinoic acid receptor RXR-gammaAlternative name(s):
Nuclear receptor subfamily 2 group B member 3Retinoid X receptor gamma
- RS10800098 (RXRG) ??
- RS1128977 (RXRG) ??
- RS2134095 (RXRG) ??
- RS2651860 (RXRG) ??
- RS283696 (RXRG) ??
- RS285480 (RXRG) ??
- RS466639 (RXRG) ??
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Top Gene-Substance Interactions
RXRG Interacts with These Diseases
| Disease | Score |
Fixes
FIX: Eat liver or supplement with retinol, Fish Oil/DHA, Relora : A source of Magnolol (Ref) and Honokiol (Ref) Read: The Importance of Real Vitamin A (Retinol)
Substances That Increase RXRG
| Substances | Interaction | Organism | Category |
Substances That Decrease RXRG
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Steroid Hormone Receptor Activity
- 9-Cis Retinoic Acid Receptor Activity
- Zinc Ion Binding
Biological Processes:
- Transcription Initiation From Rna Polymerase Ii Promoter
- Protein Homotetramerization
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Cellular Response To Chemical Stimulus