Summary of RXRB
The gene codes for a protein, retinoid X receptor beta. The protein increases both DNA binding and transcriptional function on their respective response elements [R].
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The Function of RXRB
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).
Protein names
Recommended name:
Retinoic acid receptor RXR-betaAlternative name(s):
Nuclear receptor subfamily 2 group B member 2Retinoid X receptor beta
- RS2076310 (RXRB) ??
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Top Gene-Substance Interactions
RXRB Interacts with These Diseases
| Disease | Score |
Substances That Increase RXRB
| Substances | Interaction | Organism | Category |
Substances That Decrease RXRB
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in a variety of tumor cell lines.
Gene Pathways:
Molecular Function:
- 9-Cis Retinoic Acid Receptor Activity
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- Steroid Hormone Receptor Activity
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Coactivator Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Zinc Ion Binding
- Thyroid Hormone Receptor Coactivator Activity
Biological Processes:
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription Initiation From Rna Polymerase Ii Promoter
- Regulation Of Myelination