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  3. RXRB

RXRB (Retinoid X receptor beta)

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Summary of RXRB

The gene codes for a protein, retinoid X receptor beta. The protein increases both DNA binding and transcriptional function on their respective response elements [R].

0 users want this gene increased, 0 users want it decreased

The Function of RXRB

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).

Protein names

Recommended name:

Retinoic acid receptor RXR-beta

Alternative name(s):

Nuclear receptor subfamily 2 group B member 2
Retinoid X receptor beta

RXRB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2076310 (RXRB) ??

Top Gene-Substance Interactions

RXRB Interacts with These Diseases

Disease Score

Substances That Increase RXRB

Substances Interaction Organism Category

Substances That Decrease RXRB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2

Tissue specificity:

Expressed in a variety of tumor cell lines.

Gene Pathways:

  • Pathways in cancer
  • PPAR signaling pathway
  • Gene Expression
  • Adipocytokine signaling pathway
  • Thyroid cancer
  • Small cell lung cancer
  • Non-small cell lung cancer

Molecular Function:

  • 9-Cis Retinoic Acid Receptor Activity
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
  • Steroid Hormone Receptor Activity
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Coactivator Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Zinc Ion Binding
  • Thyroid Hormone Receptor Coactivator Activity

Biological Processes:

  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Transcription Initiation From Rna Polymerase Ii Promoter
  • Regulation Of Myelination

Drug Bank:

  • Adapalene
  • Alitretinoin
  • Bexarotene
  • Tazarotene
  • Tretinoin
  • Acitretin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| retinoic acid receptor, beta| AL023085| CB1_000487047| D623_10004245| daudi6| h-2riibp| H920_15451| I79_013177| M91_02563| MDA_GLEAN10006857| MHC class I promoter binding protein| MHC class I regulatory element-binding protein H-2RIIBP| Nr2b2| nuclear receptor co-regulator 1| nuclear receptor coregulator 1| Nuclear receptor subfamily 2 group B member 2| PAL_GLEAN10007110| PANDA_002281| putative retinoid X receptor beta| RCoR-1| Retinoic acid receptor RXR-beta| retinoid X receptor beta 1| retinoid X receptor, beta isoform 4-like protein| Rub| rxrb1| rxrb-a| rxrb-b| RXRbeta| RXR-beta| TREES_T100014566| xRXR beta| rxrb

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