Summary of RORB
The gene codes for a protein, RAR related orphan receptor B. The protein helps to regulate the expression of genes related to the circadian rhythm [R].
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The Function of RORB
Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4.
Protein names
Recommended name:
Nuclear receptor ROR-betaAlternative name(s):
Nuclear receptor RZR-betaNuclear receptor subfamily 1 group F member 2
Retinoid-related orphan receptor-beta
- RS3750420 (RORB) ??
- RS7042950 (RORB) ??
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Top Gene-Substance Interactions
Substances That Increase RORB
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Substances That Decrease RORB
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
- Sequence-Specific Dna Binding
- Steroid Hormone Receptor Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Zinc Ion Binding
- Melatonin Receptor Activity
Biological Processes:
- Amacrine Cell Differentiation
- Cellular Response To Retinoic Acid
- Eye Photoreceptor Cell Development
- Negative Regulation Of Osteoblast Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Regulation Of Circadian Rhythm
- Regulation Of Transcription, Dna-Templated
- Retina Development In Camera-Type Eye
- Retinal Cone Cell Development
- Retinal Rod Cell Development
- Rhythmic Process
- Transcription Initiation From Rna Polymerase Ii Promoter
- Visual Perception
- Brain Development
- Circadian Rhythm