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  3. RORB

RORB (RAR related orphan receptor B)

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Summary of RORB

The gene codes for a protein, RAR related orphan receptor B. The protein helps to regulate the expression of genes related to the circadian rhythm [R].

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The Function of RORB

Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4.

Protein names

Recommended name:

Nuclear receptor ROR-beta

Alternative name(s):

Nuclear receptor RZR-beta
Nuclear receptor subfamily 1 group F member 2
Retinoid-related orphan receptor-beta

RORB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS3750420 (RORB) ??
  2. RS7042950 (RORB) ??

Top Gene-Substance Interactions

Substances That Increase RORB

Substances Interaction Organism Category

Substances That Decrease RORB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2

Gene Pathways:

  • Circadian rhythm - mammal

Molecular Function:

  • Rna Polymerase Ii Transcription Factor Activity, Ligand-Activated Sequence-Specific Dna Binding
  • Sequence-Specific Dna Binding
  • Steroid Hormone Receptor Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Zinc Ion Binding
  • Melatonin Receptor Activity

Biological Processes:

  • Amacrine Cell Differentiation
  • Cellular Response To Retinoic Acid
  • Eye Photoreceptor Cell Development
  • Negative Regulation Of Osteoblast Differentiation
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription, Dna-Templated
  • Regulation Of Circadian Rhythm
  • Regulation Of Transcription, Dna-Templated
  • Retina Development In Camera-Type Eye
  • Retinal Cone Cell Development
  • Retinal Rod Cell Development
  • Rhythmic Process
  • Transcription Initiation From Rna Polymerase Ii Promoter
  • Visual Perception
  • Brain Development
  • Circadian Rhythm

Drug Bank:

  • Melatonin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| transcription factor| RAR-related orphan receptor A| A306_12053| Anapl_07541| AS27_02950| AS28_10925| bA133M9.1| CB1_002439002| D623_10034418| GW7_18853| hstp| I79_022010| M91_08000| M959_05028| N300_09201| N301_11849| N302_05747| N303_10040| N305_12188| N306_02598| N307_14309| N308_11397| N309_10686| N311_01289| N312_12650| N320_03158| N321_13601| N324_07400| N325_00497| N326_10289| N327_07098| N329_02513| N330_05920| N333_10132| N334_03763| N336_12091| N340_13332| N341_09629| NR1F2| nuclear orphan receptor ROR-beta| Nuclear receptor ROR-beta| nuclear receptor RZR-beta| nuclear receptor subfamily 1 group F member 2| PAL_GLEAN10021097| PANDA_014042| RAR-related orphan receptor B| RAR-related orphan receptor beta| retinoic acid-binding receptor beta| retinoid-related orphan receptor b| retinoid-related orphan receptor beta| retinoid-related orphan receptor-beta| RORA| ror beta| Rorbeta| ROR-BETA| rzrb| RZR-BETA| TREES_T100020732| UY3_12429| Y1Q_003535| Y956_00239| Z169_08583| rorb

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