Summary of NPY
The NPY gene encodes a protein called neuropeptide Y [R].
NPY is a small protein that acts as a messenger in the nervous system. It is mostly found in the brain, but it is also released in nerve cells in the rest of the body. It helps the brain regulate [R]:
- The “fight or flight” response [R]
- Appetite and eating habits [R]
- Stress and anxiety [R]
- Menstruation cycles [R]
- Sleep cycles [R]
- Pain perception [R]
- Blood pressure [R]
- Sex drive [R]
NPY levels may be affected by [R, R]:
Nicotine [R]
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Protein names
Recommended name:
Pro-neuropeptide Y [Cleaved into: Neuropeptide YShort name:
NPYAlternative name(s):
Neuropeptide tyrosineCPON
- RS1468271 (NPY) ??
- RS16139 (NPY) ??
- RS16147 (NPY) ??
- RS16149 (NPY) ??
- RS2521634 (NPY) ??
- RS28459952 (NPY) ??
- RS5574 (NPY) ??
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Top Gene-Substance Interactions
NPY Interacts with These Diseases
| Disease | Score |
Substances That Increase NPY
| Substances | Interaction | Organism | Category |
Substances That Decrease NPY
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Gene Pathways:
Molecular Function:
- G-Protein Coupled Receptor Binding
- G-Protein Coupled Receptor Activity
- Receptor Binding
- Neuropeptide Hormone Activity
- Calcium Channel Regulator Activity
Biological Processes:
- Response To Yeast
- Calcium Ion Transport
- Movement Of Cell Or Subcellular Component
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Neuropeptide Signaling Pathway
- Chemical Synaptic Transmission
- Digestion
- Behavior
- Feeding Behavior
- Blood Circulation
- Regulation Of Blood Pressure
- Cell Proliferation
- Adult Feeding Behavior
- Antibacterial Humoral Response
- Antifungal Humoral Response
- Central Nervous System Neuron Development
- Cerebral Cortex Development
- Neuron Projection Development
- Regulation Of Appetite
- Positive Regulation Of Appetite
- Innate Immune Response
- Defense Response To Gram-Negative Bacterium
- Defense Response To Gram-Positive Bacterium