Summary of NPY
The NPY gene encodes a protein called neuropeptide Y [R].
NPY is a small protein that acts as a messenger in the nervous system. It is mostly found in the brain, but it is also released in nerve cells in the rest of the body. It helps the brain regulate [R]:
- The “fight or flight” response [R]
- Appetite and eating habits [R]
- Stress and anxiety [R]
- Menstruation cycles [R]
- Sleep cycles [R]
- Pain perception [R]
- Blood pressure [R]
- Sex drive [R]
NPY levels may be affected by [R, R]:
Nicotine [R]
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Protein names
Recommended name:
Pro-neuropeptide Y [Cleaved into: Neuropeptide YShort name:
NPYAlternative name(s):
Neuropeptide tyrosineCPON
- RS1468271 (NPY) ??
- RS16139 (NPY) ??
- RS16149 (NPY) ??
- RS2521634 (NPY) ??
- RS28459952 (NPY) ??
- RS5574 (NPY) ??
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Top Gene-Substance Interactions
NPY Interacts with These Diseases
| Disease | Score |
Substances That Increase NPY
| Substances | Interaction | Organism | Category |
Substances That Decrease NPY
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Gene Pathways:
Molecular Function:
- Calcium Channel Regulator Activity
- G-Protein Coupled Receptor Activity
- G-Protein Coupled Receptor Binding
- Neuropeptide Hormone Activity
- Receptor Binding
Biological Processes:
- Adult Feeding Behavior
- Antibacterial Humoral Response
- Antifungal Humoral Response
- Behavior
- Blood Circulation
- Calcium Ion Transport
- Cell Proliferation
- Central Nervous System Neuron Development
- Cerebral Cortex Development
- Chemical Synaptic Transmission
- Defense Response To Gram-Negative Bacterium
- Defense Response To Gram-Positive Bacterium
- Digestion
- Feeding Behavior
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Innate Immune Response
- Movement Of Cell Or Subcellular Component
- Neuron Projection Development
- Neuropeptide Signaling Pathway
- Positive Regulation Of Appetite
- Regulation Of Appetite
- Regulation Of Blood Pressure
- Response To Yeast