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  3. IL3

IL3 (Interleukin 3)

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Summary of IL3

IL-3 is a cytokine that stimulates the Th2 immune system.

0 users want this gene increased, 0 users want it decreased

The Function of IL3

This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Protein names

Recommended name:

Interleukin-3

Short name:

IL-3

Alternative name(s):

Hematopoietic growth factor
Mast cell growth factor
MCGF
Multipotential colony-stimulating factor
P-cell-stimulating factor

IL3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2073506 (IL3) ??
  2. RS3091338 (IL3) ??
  3. RS40401 (IL3) ??

Top Gene-Substance Interactions

IL3 Interacts with These Diseases

Disease Score

Substances That Increase IL3

Substances Interaction Organism Category

Substances That Decrease IL3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • STAT5A
  • STAT5B
  • STAT1
  • GATA-1
  • AML1a
  • GATA-2
  • GATA-3
  • c-Myb

Tissue specificity:

Activated T-cells, mast cells, natural killer cells.

Gene Pathways:

  • Immune System
  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway
  • Apoptosis
  • Asthma
  • Hematopoietic cell lineage
  • Fc epsilon RI signaling pathway

Molecular Function:

  • Cytokine Activity
  • Interleukin-3 Receptor Binding
  • Protein Tyrosine Kinase Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Cell-Cell Signaling
  • Cytokine-Mediated Signaling Pathway
  • Embryonic Hemopoiesis
  • Immune Response
  • Mapk Cascade
  • Nervous System Development
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Dna Replication
  • Positive Regulation Of Mast Cell Proliferation
  • Positive Regulation Of Myeloid Leukocyte Differentiation
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein

Drug Bank:

  • Amlexanox
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

BPA| PSF| colony-stimulating factor, multiple| Csfmu| EGK_16827| HCGF| hematopoietic growth factor| IL-3| interleukin-3| interleukin 3 (colony-stimulating factor, multiple)| MA_m002_jsm762B1f| mast cell growth factor| mast-cell growth factor| MCGF| MULTI-CSF| multilineage-colony-stimulating factor| Multipotential colony-stimulating factor| P-cell stimulating factor| P-cell-stimulating factor| il3

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