• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. IL17A

IL17A (Interleukin 17A)

Loading...

Summary of IL17A

This gene encodes a protein that binds to interleukin 17A. They play a pathogenic role in many inflammatory and autoimmune diseases like rheumatoid arthritis (R). 

0 users want this gene increased, 0 users want it decreased

The Function of IL17A

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Protein names

Recommended name:

Interleukin-17A

Short name:

IL-17

Alternative name(s):

IL-17A
Cytotoxic T-lymphocyte-associated antigen 8
CTLA-8

IL17A SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2275913 (IL17A) ??
  2. RS3748067 (IL17A) ??
  3. RS3804513 (IL17A) ??
  4. RS3819024 (IL17A) ??
  5. RS3819025 (IL17A) ??
  6. RS4711998 (IL17A) ??
  7. RS8193036 (IL17A) ??
  8. RS8193037 (IL17A) ??

Top Gene-Substance Interactions

IL17A Interacts with These Diseases

Disease Score

Substances That Increase IL17A

Substances Interaction Organism Category

Substances That Decrease IL17A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • AP-1
  • c-Jun
  • STAT3
  • NF-kappaB1
  • C/EBPalpha
  • STAT5A
  • c-Fos
  • GATA-3
  • Fra-1

Tissue specificity:

Restricted to activated memory T-cells.

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Rheumatoid arthritis

Molecular Function:

  • Cytokine Activity
  • Cytokine Receptor Binding

Biological Processes:

  • Apoptotic Process
  • Cell-Cell Signaling
  • Cell Death
  • Cell Surface Receptor Signaling Pathway
  • Cellular Response To Interleukin-1
  • Defense Response To Fungus
  • Fibroblast Activation
  • Immune Response
  • Inflammatory Response
  • Positive Regulation Of Cytokine Production Involved In Inflammatory Response
  • Positive Regulation Of Interleukin-23 Production
  • Positive Regulation Of Interleukin-6 Secretion
  • Positive Regulation Of Osteoclast Differentiation
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Cellular Response To Glucocorticoid Stimulus
  • Positive Regulation Of Necrotic Cell Death
  • Response To Amino Acid

Drug Bank:

  • Secukinumab
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_12637| AS28_01600| CB1_025522014| ChIL-17| Ctla-8| CTLA8| cytotoxic T-lymphocyte-associated antigen 8| cytotoxic T-lymphocyte-associated protein 8| D623_10007830| EGK_15006| EH28_24512| H920_08208| Il17| IL-17| IL-17A| IL17F| IL-17F| IL-17 protein| interleukin 17| interleukin-17| interleukin 17 A| interleukin-17A| interleukin-17A-like protein| interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)| interleukin 17F| Interleukin-17F| M91_11390| M959_15263| MDA_GLEAN10014959| N300_02174| N301_07848| N305_01435| N306_11910| N307_13392| N308_13530| N321_14202| N333_04039| PAL_GLEAN10025328| PANDA_003451| TREES_T100004821| Y1Q_018822| Y956_03744| Z169_13803| il17a

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved