Summary of IL17A
This gene encodes a protein that binds to interleukin 17A. They play a pathogenic role in many inflammatory and autoimmune diseases like rheumatoid arthritis (R).
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The Function of IL17A
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Protein names
Recommended name:
Interleukin-17AShort name:
IL-17Alternative name(s):
IL-17ACytotoxic T-lymphocyte-associated antigen 8
CTLA-8
- RS2275913 (IL17A) ??
- RS3748067 (IL17A) ??
- RS3804513 (IL17A) ??
- RS3819024 (IL17A) ??
- RS3819025 (IL17A) ??
- RS4711998 (IL17A) ??
- RS8193036 (IL17A) ??
- RS8193037 (IL17A) ??
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Top Gene-Substance Interactions
IL17A Interacts with These Diseases
| Disease | Score |
Substances That Increase IL17A
| Substances | Interaction | Organism | Category |
Substances That Decrease IL17A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Restricted to activated memory T-cells.
Gene Pathways:
Molecular Function:
Biological Processes:
- Apoptotic Process
- Cell-Cell Signaling
- Cell Death
- Cell Surface Receptor Signaling Pathway
- Cellular Response To Interleukin-1
- Defense Response To Fungus
- Fibroblast Activation
- Immune Response
- Inflammatory Response
- Positive Regulation Of Cytokine Production Involved In Inflammatory Response
- Positive Regulation Of Interleukin-23 Production
- Positive Regulation Of Interleukin-6 Secretion
- Positive Regulation Of Osteoclast Differentiation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cellular Response To Glucocorticoid Stimulus
- Positive Regulation Of Necrotic Cell Death
- Response To Amino Acid
Drug Bank:
- Secukinumab