The Function of HRH1
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
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Protein names
Recommended name:
Histamine H1 receptorShort name:
H1RAlternative name(s):
HH1R- RS4684059 (HRH1) ??
- RS7651620 (HRH1) ??
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Top Gene-Substance Interactions
HRH1 Interacts with These Diseases
| Disease | Score |
Substances That Increase HRH1
| Substances | Interaction | Organism | Category |
Substances That Decrease HRH1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Inflammatory Response
- G-Protein Coupled Receptor Signaling Pathway
- Phospholipase C-Activating G-Protein Coupled Receptor Signaling Pathway
- Memory
- Visual Learning
- Regulation Of Vasoconstriction
- Positive Regulation Of Inositol Trisphosphate Biosynthetic Process
- Regulation Of Vascular Permeability
- Positive Regulation Of Vasoconstriction
- Inositol Phosphate-Mediated Signaling
- Regulation Of Synaptic Plasticity
- Eosinophil Chemotaxis
- Modulation Of Synaptic Transmission
- Cellular Response To Histamine
Drug Bank:
- Alimemazine
- Benzatropine
- Chlorphenamine
- Dimetindene
- Mepyramine
- Alcaftadine
- Amoxapine
- Antazoline
- Aripiprazole
- Asenapine
- Astemizole
- Azelastine
- Bepotastine
- Betahistine
- Brompheniramine
- Buclizine
- Butriptyline
- Carbinoxamine
- Cariprazine
- Cetirizine
- Chlorcyclizine
- Chloropyramine
- Chlorpromazine
- Chlorprothixene
- Cinnarizine
- Clemastine
- Clofedanol
- Clozapine
- Cyclizine
- Desipramine
- Desloratadine
- Dexbrompheniramine
- Dimenhydrinate
- Diphenhydramine
- Diphenylpyraline
- Doxepin
- Emedastine
- Epinastine
- Escitalopram
- Fexofenadine
- Flunarizine
- Hydroxyzine
- Iloperidone
- Imipramine
- Isothipendyl
- Ketotifen
- Levocabastine
- Levocetirizine
- Loxapine
- Maprotiline
- Meclizine
- Mequitazine
- Methotrimeprazine
- Olopatadine
- Paliperidone
- Zuclopenthixol
- Mirtazapine
- Nortriptyline
- Olanzapine
- Phenindamine
- Pheniramine
- Promazine
- Promethazine
- Propiomazine
- Quetiapine
- Risperidone
- Trazodone
- Trimipramine
- Tripelennamine
- Triprolidine
- Ziprasidone
- Aceprometazine
- Amitriptyline
- Azatadine
- Bromodiphenhydramine
- Citalopram
- Cyproheptadine
- Doxylamine
- Histamine Phosphate
- Loratadine
- Methdilazine
- Mianserin
- Orphenadrine
- Tolazoline