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  3. CYP2D6

CYP2D6 (Cytochrome P450 family 2 subfamily D member 6)

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Summary of CYP2D6

CYP2D6 is responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

The CYP2D6 enzymes metabolize about 25% of pharmaceutical drugs such as SSRIs, opioids, tamoxifen, Nyquil, and beta blockers.  

It also metabolizes serotonin and neurosteroids (pregnenolone, cholesterol, androsterone, etc). There are several important polymorphisms in CYP2D6 which cause either extensive or very poor metabolism “ or something in between.  

There are both good and bad potential consequences from being a poor or extensive metabolizer. Being a poor metabolizer may reduce the risk of some cancers such as bladder or lung.  

On the other hand, it also may significantly increase the risk of Parkinson's disease for those exposed to pesticides.  Knowing whether you're a fast or slow metabolizer may make it easier to find the right dosage of certain medications.

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Protein names

Recommended name:

Cytochrome P450 2D6

Short name:

CYPIID6

Alternative name(s):

Cholesterol 25-hydroxylase
Cytochrome P450-DB1
Debrisoquine 4-hydroxylase

CYP2D6 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1058172 (CYP2D6) ??
  2. RS1065852 (CYP2D6) ??
  3. RS1080985 (CYP2D6) ??
  4. RS1135824 (CYP2D6) ??
  5. RS1135840 (CYP2D6) ??
  6. RS16947 (CYP2D6) ??
  7. RS28371706 (CYP2D6) ??
  8. RS28371725 (CYP2D6) ??
  9. RS3892097 (CYP2D6) ??
  10. RS5030655 (CYP2D6) ??
  11. RS5030867 (CYP2D6) ??
  12. RS59421388 (CYP2D6) ??
  13. RS61736512 (CYP2D6) ??

Top Gene-Substance Interactions

CYP2D6 Interacts with These Diseases

Disease Score

Substances That Increase CYP2D6

Substances Interaction Organism Category

Substances That Decrease CYP2D6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • AhR
  • NF-kappaB1

Gene Pathways:

  • Metabolism
  • Drug metabolism - cytochrome P450

Induction:

By pregnancy.

Molecular Function:

  • Arachidonic Acid Epoxygenase Activity
  • Aromatase Activity
  • Drug Binding
  • Heme Binding
  • Iron Ion Binding
  • Monooxygenase Activity
  • Oxidoreductase Activity
  • Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
  • Oxygen Binding
  • Steroid Hydroxylase Activity

Biological Processes:

  • Alkaloid Catabolic Process
  • Alkaloid Metabolic Process
  • Arachidonic Acid Metabolic Process
  • Coumarin Metabolic Process
  • Drug Catabolic Process
  • Drug Metabolic Process
  • Heterocycle Metabolic Process
  • Isoquinoline Alkaloid Metabolic Process
  • Monoterpenoid Metabolic Process
  • Negative Regulation Of Binding
  • Negative Regulation Of Cellular Organofluorine Metabolic Process
  • Oxidation-Reduction Process
  • Oxidative Demethylation
  • Steroid Metabolic Process
  • Xenobiotic Metabolic Process

Drug Bank:

  • Aminophenazone
  • Arformoterol
  • Atomoxetine
  • Benzatropine
  • Acebutolol
  • Acetaminophen
  • Acetylcholine
  • Almotriptan
  • Alogliptin
  • Alprenolol
  • Amiodarone
  • Amlodipine
  • Amodiaquine
  • Amoxapine
  • Amphetamine
  • Amprenavir
  • Antipyrine
  • Aprindine
  • Aripiprazole
  • Artemether
  • Asenapine
  • Atorvastatin
  • Azelastine
  • Benzyl Alcohol
  • Bepridil
  • Betaxolol
  • Biperiden
  • Bisoprolol
  • Bortezomib
  • Brexpiprazole
  • Brompheniramine
  • Bupivacaine
  • Captopril
  • Chlorphenamine
  • Cinacalcet
  • Dapagliflozin
  • Dexmethylphenidate
  • Duloxetine
  • Enzalutamide
  • Erlotinib
  • Fingolimod
  • Formoterol
  • Ibrutinib
  • Imatinib
  • Ipratropium Bromide
  • Levomilnacipran
  • Mepyramine
  • Buspirone
  • Carbinoxamine
  • Cariprazine
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Cevimeline
  • Chlordiazepoxide
  • Chloroquine
  • Chlorpromazine
  • Chlorzoxazone
  • Ciclesonide
  • Cilostazol
  • Cimetidine
  • Cinnarizine
  • Cisapride
  • Clemastine
  • Clevidipine
  • Clobazam
  • Clomipramine
  • Clonidine
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine
  • Cyclobenzaprine
  • Cyclophosphamide
  • Darifenacin
  • Debrisoquin
  • Delavirdine
  • Desipramine
  • Desloratadine
  • Dexamethasone
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan
  • Dextropropoxyphene
  • Dihydrocodeine
  • Diltiazem
  • Diphenhydramine
  • Dolasetron
  • Domperidone
  • Donepezil
  • Dopamine
  • Doxazosin
  • Doxorubicin
  • Dronedarone
  • Efavirenz
  • Eletriptan
  • Encainide
  • Epinastine
  • Escitalopram
  • Ethylmorphine
  • Etoricoxib
  • Fesoterodine
  • Fexofenadine
  • Flecainide
  • Flunarizine
  • Fluoxetine
  • Fluvastatin
  • Fluvoxamine
  • Galantamine
  • Gefitinib
  • Glutethimide
  • Granisetron
  • Haloperidol
  • Halothane
  • Histamine Phosphate
  • Hydrocodone
  • Hydroxychloroquine
  • Hydroxyurea
  • Hydroxyzine
  • Idarubicin
  • Iloperidone
  • Indinavir
  • Irbesartan
  • Isoniazid
  • Itraconazole
  • Ixazomib
  • Labetalol
  • Lercanidipine
  • Levodopa
  • Lidocaine
  • Lisuride
  • Loperamide
  • Lopinavir
  • Loratadine
  • Lorcaserin
  • Lumefantrine
  • Maprotiline
  • Mefloquine
  • Mequitazine
  • Methadone
  • Methamphetamine
  • Methazolamide
  • Methimazole
  • Methotrimeprazine
  • Methoxyflurane
  • Methylphenidate
  • Methyprylon
  • Metoclopramide
  • Mexiletine
  • Mianserin
  • Miconazole
  • Mifepristone
  • Minaprine
  • Mirabegron
  • Mirtazapine
  • Moclobemide
  • Metoprolol
  • Lansoprazole
  • Nicotinamide
  • Nilotinib
  • Nitrofural
  • Paliperidone
  • Pethidine
  • Pipotiazine
  • Rolapitant
  • Rotigotine
  • Tiotropium
  • Tolterodine
  • Trospium
  • Umeclidinium
  • Vemurafenib
  • Vilazodone
  • Zuclopenthixol
  • Nateglinide
  • Nebivolol
  • Nefazodone
  • Netupitant
  • Nevirapine
  • Niacin
  • Nicardipine
  • Nicergoline
  • Nifedipine
  • Nortriptyline
  • Olanzapine
  • Omeprazole
  • Ondansetron
  • Oxprenolol
  • Oxybutynin
  • Oxycodone
  • Oxymetholone
  • Palonosetron
  • Panobinostat
  • Paroxetine
  • Pazopanib
  • Pentamidine
  • Pergolide
  • Perphenazine
  • Phenformin
  • Phentermine
  • Pimozide
  • Pioglitazone
  • Piperazine
  • Ponatinib
  • Pravastatin
  • Praziquantel
  • Primaquine
  • Prochlorperazine
  • Progesterone
  • Proguanil
  • Promethazine
  • Propafenone
  • Propofol
  • Protriptyline
  • Pseudoephedrine
  • Pyrimethamine
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranitidine
  • Ranolazine
  • Reboxetine
  • Remoxipride
  • Risperidone
  • Ritonavir
  • Rivastigmine
  • Ropinirole
  • Ropivacaine
  • Saquinavir
  • Selegiline
  • Sertindole
  • Sertraline
  • Sildenafil
  • Sorafenib
  • Sulfanilamide
  • Sulfaphenazole
  • Tamoxifen
  • Tamsulosin
  • Telithromycin
  • Temsirolimus
  • Terbinafine
  • Tetrabenazine
  • Theophylline
  • Thioridazine
  • Thiothixene
  • Timolol
  • Tipranavir
  • Trabectedin
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Tripelennamine
  • Triprolidine
  • Venlafaxine
  • Verapamil
  • Vinblastine
  • Vinorelbine
  • Yohimbine
  • Zafirlukast
  • Zalcitabine
  • Ziprasidone
  • Abiraterone
  • Ajmaline
  • Amitriptyline
  • Amsacrine
  • Astemizole
  • Bicalutamide
  • Buprenorphine
  • Bupropion
  • Caffeine
  • Cephalexin
  • Cholecalciferol
  • Citalopram
  • Clotrimazole
  • Cyclosporine
  • Dexfenfluramine
  • Dimethyl Sulfoxide
  • Doxepin
  • Eliglustat
  • Felodipine
  • Fluphenazine
  • Halofantrine
  • Hydromorphone
  • Imipramine
  • Ketoconazole
  • Lomustine
  • Lovastatin
  • Mesoridazine
  • Methylnaltrexone
  • Midodrine
  • Morphine
  • Naloxegol
  • Nelfinavir
  • Oxamniquine
  • Oxymorphone
  • Perhexiline
  • Pindolol
  • Procainamide
  • Propranolol
  • Rabeprazole
  • Rifapentine
  • Rosiglitazone
  • Simvastatin
  • Tapentadol
  • Ticlopidine
  • Trimipramine
  • Vortioxetine
  • Zolpidem
  • Nicotine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| flavoprotein-linked monooxygenase| microsomal monooxygenase| xenobiotic monooxygenase| cholesterol 25-hydroxylase| CPD6| CYP2D| cyp2d2| CYP2D42| CYP2D7AP| CYP2D7BP| CYP2D7P2| CYP2D8P2| CYP2DL1| CYPIID6| cytochrome 2D6| cytochrome P450 2D6| cytochrome P450 CYP2D42| cytochrome P450-DB1| cytochrome P450, family 2, subfamily D, polypeptide 6| cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2| cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2| cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2| cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1| cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6| cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2| debrisoquine 4-hydroxylase| nonfunctional cytochrome P450 2D6| P450C2D| P450DB1| P450-DB1| cyp2d6

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