Summary of CYP2D6
CYP2D6 is responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
The CYP2D6 enzymes metabolize about 25% of pharmaceutical drugs such as SSRIs, opioids, tamoxifen, Nyquil, and beta blockers.
It also metabolizes serotonin and neurosteroids (pregnenolone, cholesterol, androsterone, etc). There are several important polymorphisms in CYP2D6 which cause either extensive or very poor metabolism “ or something in between.
There are both good and bad potential consequences from being a poor or extensive metabolizer. Being a poor metabolizer may reduce the risk of some cancers such as bladder or lung.
On the other hand, it also may significantly increase the risk of Parkinson's disease for those exposed to pesticides. Knowing whether you're a fast or slow metabolizer may make it easier to find the right dosage of certain medications.
Protein names
Recommended name:
Cytochrome P450 2D6Short name:
CYPIID6Alternative name(s):
Cholesterol 25-hydroxylaseCytochrome P450-DB1
Debrisoquine 4-hydroxylase
- RS1058172 (CYP2D6) ??
- RS1065852 (CYP2D6) ??
- RS1080985 (CYP2D6) ??
- RS1135824 (CYP2D6) ??
- RS1135840 (CYP2D6) ??
- RS16947 (CYP2D6) ??
- RS28371706 (CYP2D6) ??
- RS28371725 (CYP2D6) ??
- RS3892097 (CYP2D6) ??
- RS5030655 (CYP2D6) ??
- RS5030867 (CYP2D6) ??
- RS59421388 (CYP2D6) ??
- RS61736512 (CYP2D6) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
CYP2D6 Interacts with These Diseases
Disease | Score |
Substances That Increase CYP2D6
Substances | Interaction | Organism | Category |
Substances That Decrease CYP2D6
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
By pregnancy.
Molecular Function:
- Arachidonic Acid Epoxygenase Activity
- Aromatase Activity
- Drug Binding
- Heme Binding
- Iron Ion Binding
- Monooxygenase Activity
- Oxidoreductase Activity
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
- Oxygen Binding
- Steroid Hydroxylase Activity
Biological Processes:
- Alkaloid Catabolic Process
- Alkaloid Metabolic Process
- Arachidonic Acid Metabolic Process
- Coumarin Metabolic Process
- Drug Catabolic Process
- Drug Metabolic Process
- Heterocycle Metabolic Process
- Isoquinoline Alkaloid Metabolic Process
- Monoterpenoid Metabolic Process
- Negative Regulation Of Binding
- Negative Regulation Of Cellular Organofluorine Metabolic Process
- Oxidation-Reduction Process
- Oxidative Demethylation
- Steroid Metabolic Process
- Xenobiotic Metabolic Process
Drug Bank:
- Aminophenazone
- Arformoterol
- Atomoxetine
- Benzatropine
- Acebutolol
- Acetaminophen
- Acetylcholine
- Almotriptan
- Alogliptin
- Alprenolol
- Amiodarone
- Amlodipine
- Amodiaquine
- Amoxapine
- Amphetamine
- Amprenavir
- Antipyrine
- Aprindine
- Aripiprazole
- Artemether
- Asenapine
- Atorvastatin
- Azelastine
- Benzyl Alcohol
- Bepridil
- Betaxolol
- Biperiden
- Bisoprolol
- Bortezomib
- Brexpiprazole
- Brompheniramine
- Bupivacaine
- Captopril
- Chlorphenamine
- Cinacalcet
- Dapagliflozin
- Dexmethylphenidate
- Duloxetine
- Enzalutamide
- Erlotinib
- Fingolimod
- Formoterol
- Ibrutinib
- Imatinib
- Ipratropium Bromide
- Levomilnacipran
- Mepyramine
- Buspirone
- Carbinoxamine
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Cevimeline
- Chlordiazepoxide
- Chloroquine
- Chlorpromazine
- Chlorzoxazone
- Ciclesonide
- Cilostazol
- Cimetidine
- Cinnarizine
- Cisapride
- Clemastine
- Clevidipine
- Clobazam
- Clomipramine
- Clonidine
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Cyclobenzaprine
- Cyclophosphamide
- Darifenacin
- Debrisoquin
- Delavirdine
- Desipramine
- Desloratadine
- Dexamethasone
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan
- Dextropropoxyphene
- Dihydrocodeine
- Diltiazem
- Diphenhydramine
- Dolasetron
- Domperidone
- Donepezil
- Dopamine
- Doxazosin
- Doxorubicin
- Dronedarone
- Efavirenz
- Eletriptan
- Encainide
- Epinastine
- Escitalopram
- Ethylmorphine
- Etoricoxib
- Fesoterodine
- Fexofenadine
- Flecainide
- Flunarizine
- Fluoxetine
- Fluvastatin
- Fluvoxamine
- Galantamine
- Gefitinib
- Glutethimide
- Granisetron
- Haloperidol
- Halothane
- Histamine Phosphate
- Hydrocodone
- Hydroxychloroquine
- Hydroxyurea
- Hydroxyzine
- Idarubicin
- Iloperidone
- Indinavir
- Irbesartan
- Isoniazid
- Itraconazole
- Ixazomib
- Labetalol
- Lercanidipine
- Levodopa
- Lidocaine
- Lisuride
- Loperamide
- Lopinavir
- Loratadine
- Lorcaserin
- Lumefantrine
- Maprotiline
- Mefloquine
- Mequitazine
- Methadone
- Methamphetamine
- Methazolamide
- Methimazole
- Methotrimeprazine
- Methoxyflurane
- Methylphenidate
- Methyprylon
- Metoclopramide
- Mexiletine
- Mianserin
- Miconazole
- Mifepristone
- Minaprine
- Mirabegron
- Mirtazapine
- Moclobemide
- Metoprolol
- Lansoprazole
- Nicotinamide
- Nilotinib
- Nitrofural
- Paliperidone
- Pethidine
- Pipotiazine
- Rolapitant
- Rotigotine
- Tiotropium
- Tolterodine
- Trospium
- Umeclidinium
- Vemurafenib
- Vilazodone
- Zuclopenthixol
- Nateglinide
- Nebivolol
- Nefazodone
- Netupitant
- Nevirapine
- Niacin
- Nicardipine
- Nicergoline
- Nifedipine
- Nortriptyline
- Olanzapine
- Omeprazole
- Ondansetron
- Oxprenolol
- Oxybutynin
- Oxycodone
- Oxymetholone
- Palonosetron
- Panobinostat
- Paroxetine
- Pazopanib
- Pentamidine
- Pergolide
- Perphenazine
- Phenformin
- Phentermine
- Pimozide
- Pioglitazone
- Piperazine
- Ponatinib
- Pravastatin
- Praziquantel
- Primaquine
- Prochlorperazine
- Progesterone
- Proguanil
- Promethazine
- Propafenone
- Propofol
- Protriptyline
- Pseudoephedrine
- Pyrimethamine
- Quetiapine
- Quinidine
- Quinine
- Ranitidine
- Ranolazine
- Reboxetine
- Remoxipride
- Risperidone
- Ritonavir
- Rivastigmine
- Ropinirole
- Ropivacaine
- Saquinavir
- Selegiline
- Sertindole
- Sertraline
- Sildenafil
- Sorafenib
- Sulfanilamide
- Sulfaphenazole
- Tamoxifen
- Tamsulosin
- Telithromycin
- Temsirolimus
- Terbinafine
- Tetrabenazine
- Theophylline
- Thioridazine
- Thiothixene
- Timolol
- Tipranavir
- Trabectedin
- Tramadol
- Tranylcypromine
- Trazodone
- Tripelennamine
- Triprolidine
- Venlafaxine
- Verapamil
- Vinblastine
- Vinorelbine
- Yohimbine
- Zafirlukast
- Zalcitabine
- Ziprasidone
- Abiraterone
- Ajmaline
- Amitriptyline
- Amsacrine
- Astemizole
- Bicalutamide
- Buprenorphine
- Bupropion
- Caffeine
- Cephalexin
- Cholecalciferol
- Citalopram
- Clotrimazole
- Cyclosporine
- Dexfenfluramine
- Dimethyl Sulfoxide
- Doxepin
- Eliglustat
- Felodipine
- Fluphenazine
- Halofantrine
- Hydromorphone
- Imipramine
- Ketoconazole
- Lomustine
- Lovastatin
- Mesoridazine
- Methylnaltrexone
- Midodrine
- Morphine
- Naloxegol
- Nelfinavir
- Oxamniquine
- Oxymorphone
- Perhexiline
- Pindolol
- Procainamide
- Propranolol
- Rabeprazole
- Rifapentine
- Rosiglitazone
- Simvastatin
- Tapentadol
- Ticlopidine
- Trimipramine
- Vortioxetine
- Zolpidem
- Nicotine