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  3. CYP1A2

CYP1A2 (Cytochrome P450 family 1 subfamily A member 2)

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Summary of CYP1A2

The CYP1A2 gene encodes cytochrome P450 family 1 subfamily A member 2 [R].

This enzyme is mainly found in the liver, where it helps make cholesterol and steroids. It also breaks down some drugs and toxins, including [R]:

  • Caffeine
  • Acetaminophen (Tylenol)
  • Aflatoxin B1
  • Many carcinogens
  • Heterocyclic amines (HCAs, from charred meat)

This enzyme can be blocked by some antibiotics, herbs, and herbal teas [R].

This enzyme’s activity can be increased by nicotine and cruciferous vegetables [R].

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Cytochrome P450 1A2

Short name:

CYPIA2

Alternative name(s):

Cholesterol 25-hydroxylase
Cytochrome P(3
Cytochrome P450 4
Cytochrome P450-P3

CYP1A2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12720461 (CYP1A2) ??
  2. RS2069526 (CYP1A2) ??
  3. RS2470890 (CYP1A2) ??
  4. RS2470893 (CYP1A2) ??
  5. RS2472297 (CYP1A2) ??
  6. RS2472299 (CYP1A2) ??
  7. RS2472304 (CYP1A2) ??
  8. RS28399424 (CYP1A2) ??
  9. RS72547513 (CYP1A2) ??
  10. RS762551 (CYP1A2) ??

Top Gene-Substance Interactions

CYP1A2 Interacts with These Diseases

Disease Score

Substances That Increase CYP1A2

Substances Interaction Organism Category

Substances That Decrease CYP1A2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • AhR
  • Arnt
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • c-Fos

Tissue specificity:

Liver.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Steroid hormone biosynthesis
  • Linoleic acid metabolism
  • Tryptophan metabolism
  • Metabolism of xenobiotics by cytochrome P450
  • Retinol metabolism
  • Drug metabolism - cytochrome P450
  • Caffeine metabolism

Induction:

By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

Molecular Function:

  • Aromatase Activity
  • Caffeine Oxidase Activity
  • Demethylase Activity
  • Electron Carrier Activity
  • Enzyme Binding
  • Heme Binding
  • Iron Ion Binding
  • Monooxygenase Activity
  • Oxidoreductase Activity
  • Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
  • Oxygen Binding

Biological Processes:

  • Alkaloid Metabolic Process
  • Cellular Respiration
  • Cellular Response To Cadmium Ion
  • Dibenzo-P-Dioxin Metabolic Process
  • Drug Catabolic Process
  • Drug Metabolic Process
  • Epoxygenase P450 Pathway
  • Exogenous Drug Catabolic Process
  • Heterocycle Metabolic Process
  • Hydrogen Peroxide Biosynthetic Process
  • Lung Development
  • Methylation
  • Monocarboxylic Acid Metabolic Process
  • Monoterpenoid Metabolic Process
  • Omega-Hydroxylase P450 Pathway
  • Oxidation-Reduction Process
  • Oxidative Deethylation
  • Oxidative Demethylation
  • Porphyrin-Containing Compound Metabolic Process
  • Post-Embryonic Development
  • Regulation Of Gene Expression
  • Response To Estradiol
  • Response To Immobilization Stress
  • Response To Lipopolysaccharide
  • Steroid Catabolic Process
  • Toxin Biosynthetic Process
  • Xenobiotic Metabolic Process

Drug Bank:

  • Agomelatine
  • Aminophenazone
  • Cinacalcet
  • Clobetasol Propionate
  • Clomifene
  • Conjugated Estrogens
  • Dapagliflozin
  • Duloxetine
  • Erlotinib
  • Acenocoumarol
  • Acetaminophen
  • Alitretinoin
  • Almotriptan
  • Alosetron
  • Aminoglutethimide
  • Aminophylline
  • Amiodarone
  • Amlodipine
  • Anagrelide
  • Anastrozole
  • Antipyrine
  • Aprepitant
  • Armodafinil
  • Asenapine
  • Atropine
  • Azelastine
  • Azithromycin
  • Benzyl Alcohol
  • Betaxolol
  • Bortezomib
  • Bromazepam
  • Bupivacaine
  • Buprenorphine
  • Bupropion
  • Caffeine
  • Capsaicin
  • Carmustine
  • Carvedilol
  • Chlorpromazine
  • Chlorzoxazone
  • Cilostazol
  • Cimetidine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clenbuterol
  • Clomipramine
  • Clonidine
  • Clopidogrel
  • Clotrimazole
  • Clozapine
  • Cyclobenzaprine
  • Dasatinib
  • Daunorubicin
  • Delavirdine
  • Desipramine
  • Desloratadine
  • Dexfenfluramine
  • Diazepam
  • Diclofenac
  • Dinoprostone
  • Diphenhydramine
  • Domperidone
  • Dopamine
  • Doxepin
  • Efavirenz
  • Eltrombopag
  • Enoxacin
  • Epinephrine
  • Erythromycin
  • Estradiol
  • Estrone
  • Estropipate
  • Ethanol
  • Etoposide
  • Flunarizine
  • Flunitrazepam
  • Fluorouracil
  • Fluoxetine
  • Fluphenazine
  • Flutamide
  • Fluvoxamine
  • Frovatriptan
  • Gemfibrozil
  • Griseofulvin
  • Guanabenz
  • Imatinib
  • Inhaled Insulin
  • Insulin Regular
  • Menadione
  • Oxtriphylline
  • Pipotiazine
  • Rifampicin
  • Rotigotine
  • Vemurafenib
  • Hesperetin
  • Hexobarbital
  • Iloperidone
  • Imipramine
  • Insulin Aspart
  • Insulin Detemir
  • Insulin Glargine
  • Insulin Glulisine
  • Insulin Lispro
  • Irbesartan
  • Ixazomib
  • Ketoconazole
  • Leflunomide
  • Levobupivacaine
  • Levofloxacin
  • Lidocaine
  • Lopinavir
  • Lorcaserin
  • Losartan
  • Lumiracoxib
  • Malathion
  • Meclizine
  • Melatonin
  • Methadone
  • Methimazole
  • Methoxsalen
  • Methoxyflurane
  • Mexiletine
  • Mianserin
  • Miconazole
  • Moclobemide
  • Modafinil
  • Nabumetone
  • Nafcillin
  • Nelfinavir
  • Nevirapine
  • Niclosamide
  • Nilvadipine
  • Nisoldipine
  • Nitric Oxide
  • Nitroprusside
  • Norepinephrine
  • Norfloxacin
  • Ofloxacin
  • Olanzapine
  • Omeprazole
  • Ondansetron
  • Osimertinib
  • Oxymetholone
  • Palonosetron
  • Pantoprazole
  • Pazopanib
  • Pefloxacin
  • Pentamidine
  • Perphenazine
  • Phenobarbital
  • Phentermine
  • Phenylephrine
  • Pimozide
  • Praziquantel
  • Primaquine
  • Primidone
  • Progesterone
  • Proguanil
  • Promazine
  • Propofol
  • Propranolol
  • Pyrazinamide
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ranitidine
  • Rasagiline
  • Rifabutin
  • Rilpivirine
  • Ritonavir
  • Rizatriptan
  • Ropinirole
  • Ropivacaine
  • Roxithromycin
  • Secobarbital
  • Selegiline
  • Sertraline
  • Simeprevir
  • Sorafenib
  • Sulconazole
  • Sulindac
  • Tamoxifen
  • Telithromycin
  • Tenofovir
  • Thalidomide
  • Theobromine
  • Theophylline
  • Thiabendazole
  • Thioridazine
  • Thiothixene
  • Tioconazole
  • Tizanidine
  • Tocainide
  • Toremifene
  • Triamterene
  • Trifluoperazine
  • Ulipristal
  • Valproic Acid
  • Verapamil
  • Warfarin
  • Zileuton
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Nicotine
  • Lansoprazole
  • Abiraterone
  • Albendazole
  • Amitriptyline
  • Apixaban
  • Axitinib
  • Bromocriptine
  • Carbamazepine
  • Cinnarizine
  • Clevidipine
  • Dacarbazine
  • Dexmedetomidine
  • Edetic Acid
  • Ergotamine
  • Etoricoxib
  • Fluvastatin
  • Haloperidol
  • Imiquimod
  • Isoniazid
  • Lomefloxacin
  • Maprotiline
  • Methotrimeprazine
  • Mirtazapine
  • Naproxen
  • Nifedipine
  • Nortriptyline
  • Oxaliplatin
  • Pentoxifylline
  • Pomalidomide
  • Propafenone
  • Ramelteon
  • Riluzole
  • Rosiglitazone
  • Streptozocin
  • Terbinafine
  • Ticlopidine
  • Tranylcypromine
  • Zafirlukast
  • Phenylpropanolamine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

flavoprotein-linked monooxygenase| microsomal monooxygenase| aromatic compound inducible| aryl hydrocarbon hydroxylase| CYP1A5| CYPIA5| cytochrome P450 1A5| cytochrome P450 TCDDAA| xenobiotic monooxygenase| Cholesterol 25-hydroxylase| CP12| Cyp1a1| CYPD45| CYPIA2| CYPIA-2| cytochrome P(3)450| cytochrome P-448| cytochrome P450, 1a2| cytochrome P450 1A2| Cytochrome-P450-1A2| cytochrome P450, 1a2, aromatic compound inducible| cytochrome P450 4| cytochrome P-450d| cytochrome P450-D| Cytochrome P450-D2| cytochrome P450 family 1 subfamily a polypeptide 1| cytochrome P450, family 1, subfamily A, polypeptide 2| cytochrome P450-P2| cytochrome P450-P3| cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d)| Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d)| cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2| DAH2| dioxin-inducible P3-450| P3-450| P-448| P450-3| P-450d| P450-D| P450 form 4| P450(PA)| RATCYPD45| cyp1a2

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