CYP1A2 | SelfDecode | Genome Analysis

Summary of CYP1A2

CYP1A2 encodes for an enzyme (cytochrome P450 family 1 subfamily A member 2) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, substances, and other lipids (R).

It is associated with lung cancer risk because it can metabolize hydrocarbons from cigarette smoke to carcinogens (R).

Inhibitors of this enzyme include fluoroquinolones (antibiotics), bactericidal, herbs and herbal teas (R).

Inducers of the enzyme include nicotine and vegetables like broccoli or cauliflower (R).

Caffeine, aflatoxin, carcinogens, heterocyclic amines and tylenol are metabolized by CYP1A2 in the liver.

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Protein names

Recommended name:

Cytochrome P450 1A2

Short name:

CYPIA2

Alternative name(s):

Cholesterol 25-hydroxylase
Cytochrome P(3
Cytochrome P450 4
Cytochrome P450-P3

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Top Gene-Substance Interactions

CYP1A2 Interacts with These Diseases

Disease	Score

Substances That Increase CYP1A2

Category:

Substances	Interaction	Organism	Category

Substances That Decrease CYP1A2

Category:

Substances	Interaction	Organism	Category

Conditions with Increased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Conditions with Decreased Gene Activity

Experimental Variables:

Condition	Change (log₂fold)	Comparison	Species	Experimental variables	Experiment name

Technical

The following transcription factors affect gene expression:

Tissue specificity:

Liver.

Gene Pathways:

Induction:

By nicotine, omeprazole, phenobarbital, primidone and rifampicin.

Molecular Function:

Biological Processes:

Drug Bank:

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

CYP1A2 (Cytochrome P450 family 1 subfamily A member 2)

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