Summary of CYP1A2
The CYP1A2 gene encodes cytochrome P450 family 1 subfamily A member 2 [R].
This enzyme is mainly found in the liver, where it helps make cholesterol and steroids. It also breaks down some drugs and toxins, including [R]:
- Caffeine
- Acetaminophen (Tylenol)
- Aflatoxin B1
- Many carcinogens
- Heterocyclic amines (HCAs, from charred meat)
This enzyme can be blocked by some antibiotics, herbs, and herbal teas [R].
This enzyme’s activity can be increased by nicotine and cruciferous vegetables [R].
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Cytochrome P450 1A2Short name:
CYPIA2Alternative name(s):
Cholesterol 25-hydroxylaseCytochrome P(3
Cytochrome P450 4
Cytochrome P450-P3
- RS12720461 (CYP1A2) ??
- RS2069526 (CYP1A2) ??
- RS2470890 (CYP1A2) ??
- RS2470893 (CYP1A2) ??
- RS2472297 (CYP1A2) ??
- RS2472299 (CYP1A2) ??
- RS2472304 (CYP1A2) ??
- RS28399424 (CYP1A2) ??
- RS72547513 (CYP1A2) ??
- RS762551 (CYP1A2) ??
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Top Gene-Substance Interactions
CYP1A2 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP1A2
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP1A2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver.
Gene Pathways:
Induction:
By nicotine, omeprazole, phenobarbital, primidone and rifampicin.
Molecular Function:
- Aromatase Activity
- Caffeine Oxidase Activity
- Demethylase Activity
- Electron Carrier Activity
- Enzyme Binding
- Heme Binding
- Iron Ion Binding
- Monooxygenase Activity
- Oxidoreductase Activity
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
- Oxygen Binding
Biological Processes:
- Alkaloid Metabolic Process
- Cellular Respiration
- Cellular Response To Cadmium Ion
- Dibenzo-P-Dioxin Metabolic Process
- Drug Catabolic Process
- Drug Metabolic Process
- Epoxygenase P450 Pathway
- Exogenous Drug Catabolic Process
- Heterocycle Metabolic Process
- Hydrogen Peroxide Biosynthetic Process
- Lung Development
- Methylation
- Monocarboxylic Acid Metabolic Process
- Monoterpenoid Metabolic Process
- Omega-Hydroxylase P450 Pathway
- Oxidation-Reduction Process
- Oxidative Deethylation
- Oxidative Demethylation
- Porphyrin-Containing Compound Metabolic Process
- Post-Embryonic Development
- Regulation Of Gene Expression
- Response To Estradiol
- Response To Immobilization Stress
- Response To Lipopolysaccharide
- Steroid Catabolic Process
- Toxin Biosynthetic Process
- Xenobiotic Metabolic Process
Drug Bank:
- Agomelatine
- Aminophenazone
- Cinacalcet
- Clobetasol Propionate
- Clomifene
- Conjugated Estrogens
- Dapagliflozin
- Duloxetine
- Erlotinib
- Acenocoumarol
- Acetaminophen
- Alitretinoin
- Almotriptan
- Alosetron
- Aminoglutethimide
- Aminophylline
- Amiodarone
- Amlodipine
- Anagrelide
- Anastrozole
- Antipyrine
- Aprepitant
- Armodafinil
- Asenapine
- Atropine
- Azelastine
- Azithromycin
- Benzyl Alcohol
- Betaxolol
- Bortezomib
- Bromazepam
- Bupivacaine
- Buprenorphine
- Bupropion
- Caffeine
- Capsaicin
- Carmustine
- Carvedilol
- Chlorpromazine
- Chlorzoxazone
- Cilostazol
- Cimetidine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clenbuterol
- Clomipramine
- Clonidine
- Clopidogrel
- Clotrimazole
- Clozapine
- Cyclobenzaprine
- Dasatinib
- Daunorubicin
- Delavirdine
- Desipramine
- Desloratadine
- Dexfenfluramine
- Diazepam
- Diclofenac
- Dinoprostone
- Diphenhydramine
- Domperidone
- Dopamine
- Doxepin
- Efavirenz
- Eltrombopag
- Enoxacin
- Epinephrine
- Erythromycin
- Estradiol
- Estrone
- Estropipate
- Ethanol
- Etoposide
- Flunarizine
- Flunitrazepam
- Fluorouracil
- Fluoxetine
- Fluphenazine
- Flutamide
- Fluvoxamine
- Frovatriptan
- Gemfibrozil
- Griseofulvin
- Guanabenz
- Imatinib
- Inhaled Insulin
- Insulin Regular
- Menadione
- Oxtriphylline
- Pipotiazine
- Rifampicin
- Rotigotine
- Vemurafenib
- Hesperetin
- Hexobarbital
- Iloperidone
- Imipramine
- Insulin Aspart
- Insulin Detemir
- Insulin Glargine
- Insulin Glulisine
- Insulin Lispro
- Irbesartan
- Ixazomib
- Ketoconazole
- Leflunomide
- Levobupivacaine
- Levofloxacin
- Lidocaine
- Lopinavir
- Lorcaserin
- Losartan
- Lumiracoxib
- Malathion
- Meclizine
- Melatonin
- Methadone
- Methimazole
- Methoxsalen
- Methoxyflurane
- Mexiletine
- Mianserin
- Miconazole
- Moclobemide
- Modafinil
- Nabumetone
- Nafcillin
- Nelfinavir
- Nevirapine
- Niclosamide
- Nilvadipine
- Nisoldipine
- Nitric Oxide
- Nitroprusside
- Norepinephrine
- Norfloxacin
- Ofloxacin
- Olanzapine
- Omeprazole
- Ondansetron
- Osimertinib
- Oxymetholone
- Palonosetron
- Pantoprazole
- Pazopanib
- Pefloxacin
- Pentamidine
- Perphenazine
- Phenobarbital
- Phentermine
- Phenylephrine
- Pimozide
- Praziquantel
- Primaquine
- Primidone
- Progesterone
- Proguanil
- Promazine
- Propofol
- Propranolol
- Pyrazinamide
- Quinidine
- Quinine
- Rabeprazole
- Ranitidine
- Rasagiline
- Rifabutin
- Rilpivirine
- Ritonavir
- Rizatriptan
- Ropinirole
- Ropivacaine
- Roxithromycin
- Secobarbital
- Selegiline
- Sertraline
- Simeprevir
- Sorafenib
- Sulconazole
- Sulindac
- Tamoxifen
- Telithromycin
- Tenofovir
- Thalidomide
- Theobromine
- Theophylline
- Thiabendazole
- Thioridazine
- Thiothixene
- Tioconazole
- Tizanidine
- Tocainide
- Toremifene
- Triamterene
- Trifluoperazine
- Ulipristal
- Valproic Acid
- Verapamil
- Warfarin
- Zileuton
- Ziprasidone
- Zolmitriptan
- Zolpidem
- Nicotine
- Lansoprazole
- Abiraterone
- Albendazole
- Amitriptyline
- Apixaban
- Axitinib
- Bromocriptine
- Carbamazepine
- Cinnarizine
- Clevidipine
- Dacarbazine
- Dexmedetomidine
- Edetic Acid
- Ergotamine
- Etoricoxib
- Fluvastatin
- Haloperidol
- Imiquimod
- Isoniazid
- Lomefloxacin
- Maprotiline
- Methotrimeprazine
- Mirtazapine
- Naproxen
- Nifedipine
- Nortriptyline
- Oxaliplatin
- Pentoxifylline
- Pomalidomide
- Propafenone
- Ramelteon
- Riluzole
- Rosiglitazone
- Streptozocin
- Terbinafine
- Ticlopidine
- Tranylcypromine
- Zafirlukast
- Phenylpropanolamine