Summary of CYP1A2
CYP1A2 encodes for an enzyme (cytochrome P450 family 1 subfamily A member 2) and catalyzes reactions involved in drug metabolism and synthesis of cholesterol, steroids, substances, and other lipids (R).
It is associated with lung cancer risk because it can metabolize hydrocarbons from cigarette smoke to carcinogens (R).
Inhibitors of this enzyme include fluoroquinolones (antibiotics), bactericidal, herbs and herbal teas (R).
Inducers of the enzyme include nicotine and vegetables like broccoli or cauliflower (R).
Caffeine, aflatoxin, carcinogens, heterocyclic amines and tylenol are metabolized by CYP1A2 in the liver.
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Protein names
Recommended name:
Cytochrome P450 1A2Short name:
CYPIA2Alternative name(s):
Cholesterol 25-hydroxylaseCytochrome P(3
Cytochrome P450 4
Cytochrome P450-P3
- RS12720461 (CYP1A2) ??
- RS2069526 (CYP1A2) ??
- RS2470890 (CYP1A2) ??
- RS2470893 (CYP1A2) ??
- RS2472297 (CYP1A2) ??
- RS2472299 (CYP1A2) ??
- RS2472304 (CYP1A2) ??
- RS28399424 (CYP1A2) ??
- RS72547513 (CYP1A2) ??
- RS762551 (CYP1A2) ??
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Top Gene-Substance Interactions
CYP1A2 Interacts with These Diseases
| Disease | Score |
Substances That Increase CYP1A2
| Substances | Interaction | Organism | Category |
Substances That Decrease CYP1A2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Liver.
Gene Pathways:
Induction:
By nicotine, omeprazole, phenobarbital, primidone and rifampicin.
Molecular Function:
- Aromatase Activity
- Caffeine Oxidase Activity
- Demethylase Activity
- Electron Carrier Activity
- Enzyme Binding
- Heme Binding
- Iron Ion Binding
- Monooxygenase Activity
- Oxidoreductase Activity
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
- Oxygen Binding
Biological Processes:
- Alkaloid Metabolic Process
- Cellular Respiration
- Cellular Response To Cadmium Ion
- Dibenzo-P-Dioxin Metabolic Process
- Drug Catabolic Process
- Drug Metabolic Process
- Epoxygenase P450 Pathway
- Exogenous Drug Catabolic Process
- Heterocycle Metabolic Process
- Hydrogen Peroxide Biosynthetic Process
- Lung Development
- Methylation
- Monocarboxylic Acid Metabolic Process
- Monoterpenoid Metabolic Process
- Omega-Hydroxylase P450 Pathway
- Oxidation-Reduction Process
- Oxidative Deethylation
- Oxidative Demethylation
- Porphyrin-Containing Compound Metabolic Process
- Post-Embryonic Development
- Regulation Of Gene Expression
- Response To Estradiol
- Response To Immobilization Stress
- Response To Lipopolysaccharide
- Steroid Catabolic Process
- Toxin Biosynthetic Process
- Xenobiotic Metabolic Process
Drug Bank:
- Agomelatine
- Aminophenazone
- Cinacalcet
- Clobetasol Propionate
- Clomifene
- Conjugated Estrogens
- Dapagliflozin
- Duloxetine
- Erlotinib
- Acenocoumarol
- Acetaminophen
- Alitretinoin
- Almotriptan
- Alosetron
- Aminoglutethimide
- Aminophylline
- Amiodarone
- Amlodipine
- Anagrelide
- Anastrozole
- Antipyrine
- Aprepitant
- Armodafinil
- Asenapine
- Atropine
- Azelastine
- Azithromycin
- Benzyl Alcohol
- Betaxolol
- Bortezomib
- Bromazepam
- Bupivacaine
- Buprenorphine
- Bupropion
- Caffeine
- Capsaicin
- Carmustine
- Carvedilol
- Chlorpromazine
- Chlorzoxazone
- Cilostazol
- Cimetidine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clenbuterol
- Clomipramine
- Clonidine
- Clopidogrel
- Clotrimazole
- Clozapine
- Cyclobenzaprine
- Dasatinib
- Daunorubicin
- Delavirdine
- Desipramine
- Desloratadine
- Dexfenfluramine
- Diazepam
- Diclofenac
- Dinoprostone
- Diphenhydramine
- Domperidone
- Dopamine
- Doxepin
- Efavirenz
- Eltrombopag
- Enoxacin
- Epinephrine
- Erythromycin
- Estradiol
- Estrone
- Estropipate
- Ethanol
- Etoposide
- Flunarizine
- Flunitrazepam
- Fluorouracil
- Fluoxetine
- Fluphenazine
- Flutamide
- Fluvoxamine
- Frovatriptan
- Gemfibrozil
- Griseofulvin
- Guanabenz
- Imatinib
- Inhaled Insulin
- Insulin Regular
- Menadione
- Oxtriphylline
- Pipotiazine
- Rifampicin
- Rotigotine
- Vemurafenib
- Hesperetin
- Hexobarbital
- Iloperidone
- Imipramine
- Insulin Aspart
- Insulin Detemir
- Insulin Glargine
- Insulin Glulisine
- Insulin Lispro
- Irbesartan
- Ixazomib
- Ketoconazole
- Leflunomide
- Levobupivacaine
- Levofloxacin
- Lidocaine
- Lopinavir
- Lorcaserin
- Losartan
- Lumiracoxib
- Malathion
- Meclizine
- Melatonin
- Methadone
- Methimazole
- Methoxsalen
- Methoxyflurane
- Mexiletine
- Mianserin
- Miconazole
- Moclobemide
- Modafinil
- Nabumetone
- Nafcillin
- Nelfinavir
- Nevirapine
- Niclosamide
- Nilvadipine
- Nisoldipine
- Nitric Oxide
- Nitroprusside
- Norepinephrine
- Norfloxacin
- Ofloxacin
- Olanzapine
- Omeprazole
- Ondansetron
- Osimertinib
- Oxymetholone
- Palonosetron
- Pantoprazole
- Pazopanib
- Pefloxacin
- Pentamidine
- Perphenazine
- Phenobarbital
- Phentermine
- Phenylephrine
- Pimozide
- Praziquantel
- Primaquine
- Primidone
- Progesterone
- Proguanil
- Promazine
- Propofol
- Propranolol
- Pyrazinamide
- Quinidine
- Quinine
- Rabeprazole
- Ranitidine
- Rasagiline
- Rifabutin
- Rilpivirine
- Ritonavir
- Rizatriptan
- Ropinirole
- Ropivacaine
- Roxithromycin
- Secobarbital
- Selegiline
- Sertraline
- Simeprevir
- Sorafenib
- Sulconazole
- Sulindac
- Tamoxifen
- Telithromycin
- Tenofovir
- Thalidomide
- Theobromine
- Theophylline
- Thiabendazole
- Thioridazine
- Thiothixene
- Tioconazole
- Tizanidine
- Tocainide
- Toremifene
- Triamterene
- Trifluoperazine
- Ulipristal
- Valproic Acid
- Verapamil
- Warfarin
- Zileuton
- Ziprasidone
- Zolmitriptan
- Zolpidem
- Nicotine
- Lansoprazole
- Abiraterone
- Albendazole
- Amitriptyline
- Apixaban
- Axitinib
- Bromocriptine
- Carbamazepine
- Cinnarizine
- Clevidipine
- Dacarbazine
- Dexmedetomidine
- Edetic Acid
- Ergotamine
- Etoricoxib
- Fluvastatin
- Haloperidol
- Imiquimod
- Isoniazid
- Lomefloxacin
- Maprotiline
- Methotrimeprazine
- Mirtazapine
- Naproxen
- Nifedipine
- Nortriptyline
- Oxaliplatin
- Pentoxifylline
- Pomalidomide
- Propafenone
- Ramelteon
- Riluzole
- Rosiglitazone
- Streptozocin
- Terbinafine
- Ticlopidine
- Tranylcypromine
- Zafirlukast
- Phenylpropanolamine