The Function of CD226
Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.
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Protein names
Recommended name:
CD226 antigenShort name:
DNAM-1Alternative name(s):
DNAX accessory molecule 1CD antigen CD226
- RS12969657 (CD226) ??
- RS17207042 (CD226) ??
- RS2469434 (CD226) ??
- RS727088 (CD226) ??
- RS763361 (CD226) ??
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Top Gene-Substance Interactions
Substances That Increase CD226
| Substances | Interaction | Organism | Category |
Substances That Decrease CD226
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed by peripheral blood T-lymphocytes.
Gene Pathways:
Molecular Function:
- Receptor Activity
- Integrin Binding
- Protein Kinase Binding
- Protein Homodimerization Activity
- Cell Adhesion Molecule Binding
Biological Processes:
- Cytokine Production
- Positive Regulation Of Natural Killer Cell Cytokine Production
- Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
- Positive Regulation Of Immunoglobulin Mediated Immune Response
- Cell Adhesion
- Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
- Heterophilic Cell-Cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
- Signal Transduction
- Cell Recognition
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Mast Cell Activation
- Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
- Regulation Of Immune Response
- Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway