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  3. ANGPTL3

ANGPTL3 (Angiopoietin like 3)

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The Function of ANGPTL3

Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration (PubMed:11877390). Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling (PubMed:18535744). May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS.

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Protein names

Recommended name:

Angiopoietin-related protein 3

Short name:

ANG-5

Alternative name(s):

Angiopoietin-5
Angiopoietin-like protein 3
17-221
17-224

Top Gene-Substance Interactions

Substances That Increase ANGPTL3

Substances Interaction Organism Category

Substances That Decrease ANGPTL3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3

Tissue specificity:

Expressed principally in liver. Weakly expressed in kidney. Binds to adipocytes. Increased expression and colocalization with activated ITGB3 in glomeruli of patients with nephrotic syndrome showing effaced podocyte foot processes (at protein level).

Induction:

Down-regulated by insulin.

Molecular Function:

  • Enzyme Inhibitor Activity
  • Growth Factor Activity
  • Heparin Binding
  • Integrin Binding
  • Phospholipase Inhibitor Activity

Biological Processes:

  • Acylglycerol Homeostasis
  • Angiogenesis
  • Artery Morphogenesis
  • Cell-Matrix Adhesion
  • Cholesterol Homeostasis
  • Cholesterol Metabolic Process
  • Fatty Acid Metabolic Process
  • Glycerol Metabolic Process
  • Integrin-Mediated Signaling Pathway
  • Lipid Homeostasis
  • Lipid Storage
  • Negative Regulation Of Lipoprotein Lipase Activity
  • Negative Regulation Of Phospholipase Activity
  • Phospholipid Catabolic Process
  • Phospholipid Homeostasis
  • Phospholipid Metabolic Process
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Cell Migration
  • Positive Regulation Of Lipid Catabolic Process
  • Response To Hormone
  • Signal Transduction
  • Triglyceride Homeostasis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13575| ANG-5| angiopoietin 5| angiopoietin-like 3| angiopoietin-like protein 3| Angiopoietin-related protein 3| angiopotietin-like protein 3| angpt5| ANL3| AS27_01072| AS28_04161| fb60e11| fb66h02| FHBL2| H920_15346| hypl| M959_04923| N300_00633| N301_10357| N302_09233| N305_06886| N306_02442| N307_11823| N308_07990| N309_10746| N310_06777| N311_05735| N320_09717| N321_01843| N322_02496| N325_06049| N327_00884| N328_11781| N329_02136| N332_09708| N333_12749| N334_07655| N335_08639| N336_01193| N339_12146| PAL_GLEAN10023820| PANDA_006092| Z169_03028| angptl3

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