The Function of ANGPTL3
Involved in angiogenesis. Binds to endothelial cells via integrin alpha-V/beta-3 (ITGAV:ITGB3), activates FAK, MAPK and Akt signaling pathways and induces cell adhesion and cell migration (PubMed:11877390). Secreted from podocytes, may modulate properties of glomerular endothelial cells involving integrin alpha-V/beta-3 and Akt signaling (PubMed:18535744). May increase the motility of podocytes. May induce actin filament rearrangements in podocytes implicating integrin alpha-V/beta-3 and Rac1 activation. Binds to hematopoietic stem cells (HSC) and is involved in the regulation of HSC activity probably implicating down-regulation of IKZF1/IKAROS.
Protein names
Recommended name:
Angiopoietin-related protein 3Short name:
ANG-5Alternative name(s):
Angiopoietin-5Angiopoietin-like protein 3
17-221
17-224
Top Gene-Substance Interactions
Substances That Increase ANGPTL3
| Substances | Interaction | Organism | Category |
Substances That Decrease ANGPTL3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed principally in liver. Weakly expressed in kidney. Binds to adipocytes. Increased expression and colocalization with activated ITGB3 in glomeruli of patients with nephrotic syndrome showing effaced podocyte foot processes (at protein level).
Induction:
Down-regulated by insulin.
Molecular Function:
- Enzyme Inhibitor Activity
- Phospholipase Inhibitor Activity
- Integrin Binding
- Growth Factor Activity
- Heparin Binding
Biological Processes:
- Angiogenesis
- Glycerol Metabolic Process
- Fatty Acid Metabolic Process
- Phospholipid Metabolic Process
- Cell-Matrix Adhesion
- Signal Transduction
- Integrin-Mediated Signaling Pathway
- Cholesterol Metabolic Process
- Phospholipid Catabolic Process
- Response To Hormone
- Negative Regulation Of Phospholipase Activity
- Lipid Storage
- Positive Regulation Of Cell Migration
- Cholesterol Homeostasis
- Positive Regulation Of Angiogenesis
- Artery Morphogenesis
- Positive Regulation Of Lipid Catabolic Process
- Negative Regulation Of Lipoprotein Lipase Activity
- Lipid Homeostasis
- Acylglycerol Homeostasis
- Phospholipid Homeostasis
- Triglyceride Homeostasis