The Function of AMBRA1
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.
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Protein names
Recommended name:
Activating molecule in BECN1-regulated autophagy protein 1Top Gene-Substance Interactions
Substances That Increase AMBRA1
| Substances | Interaction | Organism | Category |
Substances That Decrease AMBRA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Cell Differentiation
- Macroautophagy
- Mitophagy In Response To Mitochondrial Depolarization
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Neuron Apoptotic Process
- Neural Tube Development
- Parkin-Mediated Mitophagy In Response To Mitochondrial Depolarization
- Positive Regulation Of Mitophagy
- Positive Regulation Of Phosphatidylinositol 3-Kinase Activity
- Regulation Of Autophagosome Assembly