How long does whole genome sequencing take?

After we receive your sample, processing typically takes 6-8 weeks. You will be notified as soon as your results are ready in your SelfDecode dashboard.

Is whole genome sequencing covered by HSA or FSA?

Yes. SelfDecode WGS products are HSA and FSA eligible, making it one of the most financially accessible clinical-grade sequencing services available.

What is the difference between whole genome sequencing and whole exome sequencing?

Whole exome sequencing analyzes only the protein-coding regions of your DNA (about 2% of the genome). Whole genome sequencing reads 100% of your DNA, including non-coding regions that regulate gene expression and harbor rare variants missed by exome tests.

What reports will I get from whole genome sequencing?

Depending on the package you choose, you can receive: ACMG SF v3.3 secondary findings, pharmacogenomics (PGx) reports, rare variant screening, AI-powered health insights, disease predisposition analysis, ancestry reports, and over 1,500 health-related reports.

SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more

Whole Genome Sequencing — The Most Complete DNA Test Available

Name: SelfDecode Whole Genome Sequencing (WGS) test
Brand: SelfDecode

Our Standard DNA Testing is trusted by thousands of people who want real answers. For most, it covers 98% of what they need. But for those who want every possible insight, with nothing left unexamined, our Whole Genome Sequencing (WGS) test goes further than anything else available on the market. It reads your entire genome, including the ones competitors never check for. If a dangerous variant exists in your genome, WGS will find it.

We will never share your data

We follow HIPAA and GDPR policies

We have World-Class Encryption & Security

People Love Us

Rated 4.7/5 from 750+ reviews

People Trust Us

200,000+ users, 2,000+ doctors & 100+ businesses

See What Partial DNA Tests Can Never Show

Standard DNA Testing (Genotyping)

SelfDecode’s standard DNA test uses genotyping: a fast, accessible way to explore your genetics. It analyzes around 0.1% of your genome, then uses advanced imputation to expand those results to ~200 million variants. It’s a powerful starting point for health insights and works well for the majority of our standard reports.

Whole Genome Sequencing

WGS reads all 3 billion base pairs of your DNA directly. That means full coverage of rare variants and hard-to-find changes that a standard test simply can’t reach. It is the most complete genetic picture available today.

Which one is right for you?

If you’re exploring your genetics for the first time or looking for accessible health insights, our standard DNA test is a great place to start. If you want the most complete picture of your health, including rare variant screening, clinical predisposition analysis, and advanced pharmacogenomics (PGx), WGS is the right foundation.

Why Most "Personalized" WGS Tests Miss the Point

Most competitor WGS tests use limited gene panels and automated scoring systems. They check a short list of common variants, generate a report, and call it personalization. That’s why so many people walk away with a stack of results and zero clarity on what to actually do next.

The gaps in those reports aren’t small. They miss rare variants that influence how your body processes nutrients, responds to stress, or handles specific medications. Complex gene interactions that only show up when the full picture is analyzed. Predispositions that sit quietly until they matter most, and by then you wish you’d known sooner.

Our WGS report closes those gaps. Every finding is clinically validated by our science team, not generated by an algorithm and handed to you to interpret on your own. The insights are translated into clear, actionable recommendations across nutrition, supplements, lifestyle, and long-term health planning.

Stop Relying on Genetic Guesswork

Imputation is estimation. Sequencing is measurement.

Detect Risk Earlier and More Accurately

Rare variants with large medical impact are often missed by partial testing and caught by WGS.Rare variants with large medical impact are often missed by partial testing and caught by WGS.

Build a Future-Proof Genetic Foundation

WGS is the backbone for advanced reports including disease predisposition, pharmacogenomics, longevity, and precision prevention.

People love us

Our customers say

Excellent

4.7 out of 5 based on 700+ reviews

Whole Genome & Breakthrough AI Health Expert

Imagine a doctor with unlimited time, full access to your complete genetic blueprint and one singular focus: understanding your biology at the deepest level possible.

Now combine that with your entire genome sequenced at 30x coverage, analyzed in full resolution and powered by MCP Integration, an AI health expert with direct access to your DNA. You can ask questions, explore potential risks, and receive guidance grounded in your actual genome.

This is precise, genome-level intelligence, built entirely around you. This is the foundation every WGS report is built on.

The Most Advanced 30x Whole Genome Sequencing Platform in Consumer Genetics

🧬

30x Whole Genome Sequencing

$399

Whole genome sequencing (WGS) is the most comprehensive genetic test available, capturing complete end-to-end data from all your genes and chromosomes in a single analysis. With 30× coverage whole genome sequencing, every base pair of your DNA is read an average of 30 times delivering highly accurate, clinical-grade genetic data rather than sampled or estimated results. This depth of sequencing enables precise detection of genetic variants across your entire genome and creates a permanent genomic dataset you can use for lifelong health insights, personalized medicine, disease risk analysis, and preventive care. Once sequenced, your genome becomes a lasting resource that can continue to generate new insights as genomic science advances.

💡

Whole Genome Genius Report

$599

SelfDecode user or outside the US?

Order Here

Whole Genome Genius is a next-generation whole genome sequencing (WGS) analysis that turns your complete DNA into a precision health blueprint. Unlike traditional WGS providers that primarily deliver raw genomic data, Whole Genome Genius uses advanced interpretation to identify the most clinically relevant genetic variants, metabolic pathways, pharmacogenomic insights, and disease-risk signals across your entire genome. The result is a scientifically rigorous yet actionable report that translates complex genomics into personalized strategies for health optimization, longevity, precision medicine, and preventive care, helping you understand not just your DNA, but how to use it to make smarter lifestyle, medical, and longevity decisions.

🔬

Ultimate Rare Variant Screening

$249

SelfDecode user or outside the US?

Order Here

Most genetic tests brag about scanning thousands of conditions. But scanning isn’t the same as understanding — handing you a massive list of variants and hoping you find what matters isn’t analysis. It’s a haystack.

The hard part of whole genome analysis was never the sequencing. It’s knowing what to look for. Through years of research into genomic function and biochemical pathways, SelfDecode identifies which rare variants are actually disrupting your biology, how significant the impact is, and what you can do about it — including variants that conventional reports miss entirely because they don’t know what to look for.

We don’t hand you the haystack. We extract the needles, and show you exactly what they’re doing.

Your DNA is unique. Your health analysis should be too.

⚕️

ACMG SF v3.3 Report

$249

SelfDecode user or outside the US?

Order Here

Our ACMG SF v3.3 Report reveals serious, medically actionable genetic risks years before symptoms appear. SelfDecode identifies inherited cancer, cardiovascular, and metabolic conditions that routine care often misses. These are not wellness insights. They are findings doctors use to guide real medical decisions.

See Sample | Read More

💊

Advanced Pharmacogenomics (PGx)

$199

SelfDecode user or outside the US?

Order Here

Same drug. Different person. Completely different result. Your genes control how your body breaks down medications and supplements, how fast, how slow, how well. For some people, a standard dose works perfectly. For others, that same dose does nothing, or causes side effects. This report maps your personal drug-response profile across hundreds of medications and supplements. So you can stop guessing whether something is working, and start knowing exactly why your body responds the way it does.

This is the most complete form of personal genetic data ever available.

A simple, painless test that keeps unlocking new insights

Getting your genome sequenced is as easy as brushing your teeth. No blood draw, no clinic visit, no complicated logistics.

Your sample is processed with 30x clinical‑grade whole genome sequencing in our partner labs. Once your genome is sequenced, you never need to retest: every future SelfDecode report, from disease risk and ACMG findings to pharmacogenomics and longevity, is powered by the same complete dataset.

Step 1

We mail your SelfDecode DNA kit to your door.

Step 2

You gently swab the inside of your cheek for 1–2 minutes.

Step 3

You drop the prepaid package in the mail—and you’re done.

Why WGS Changes Everything

Most genetic tests make promises their data can’t keep. They scan a fraction of your genome, estimate the rest, and call it personalization. SelfDecode’s Whole Genome Sequencing is built differently, from the ground up, for depth.

30x coverage means every base pair of your DNA is read an average of 30 times. Not sampled. Not estimated. Read, repeatedly, accurately, and completely. That’s the difference between a health plan built on your biology and one built on a best guess.

Complete Accuracy, Zero Guesswork

Every region of your genome is covered evenly and deeply. No blind spots, no low-read areas, no variants slipping through the gaps. What's in your DNA gets found.

Clinical-Grade Data You Can Actually Use

30x coverage meets the benchmark used in medical research and hospital-grade genetic analysis. That means your results aren't just informative, they're precise enough to support real health decisions, shared with your doctor or acted on directly.

Rare Variants, Finally Detected

Rare variants are the ones standard tests miss most. At 30x depth, SelfDecode reliably detects the low-frequency, high-impact variants that shape how your body really works, the ones that explain why generic advice has never fully worked for you.

A Foundation Built to Last

Your genome doesn't change. The data captured at 30x coverage stays complete and accurate for life. Ready to power new reports, answer new questions, and deliver new insights as science advances.

See Everything SelfDecode Has to Offer

Discover our full suite of health reports and features in one comprehensive guide. Our Reports & Features Summary shows all the DNA results, tools, and insights you can get with SelfDecode.

One test. Complete data. No ceiling.

Cheaper tests give partial answers. This one doesn’t. Your genome, fully sequenced, fully yours, ready to power every health decision you make from here forward.

HSA/FSA Eligible

US Based Lab & Shipping

30x Whole Genome Advanced Package

SelfDecode DNA Kit Included

Breakthrough AI Health Expert
Whole Genome Genius Report
Ultimate Rare Variant Screening
ACMG SF v3.3-Based Predisposition Report
Advanced Pharmacogenomics (PGx) Report
High-Coverage 30× Whole Genome Sequencing
Full Lifetime Access to Your Genetic Information
Permanent Privacy-First Data Protection

$1,695

$1,399

HSA & FSA Eligible

SelfDecode user or outside the US?

Order Here

30x Whole Genome Ultimate Package

SelfDecode DNA Kit Included

Everything in 30x Whole Genome Advanced Package
Advanced Genetic Analysis & Insights

High-Coverage 30× Whole Genome Sequencing
Full Lifetime Access to Your Genetic Information
Permanent Privacy-First Data Protection

$2,594

$1999

SelfDecode user or outside the US?

Order Here

HSA & FSA Eligible

30x Whole Genome Sequencing

SelfDecode DNA Kit Included
High-Coverage 30× Whole Genome Sequencing

Full Lifetime Access to Your Genetic Information
Permanent Privacy-First Data Protection

$399

We will never share your data

We follow HIPAA and GDPR policies

We have World-Class Encryption & Security

People Love Us

Rated 4.7/5 from 750+ reviews

People Trust Us

200,000+ users, 2,000+ doctors & 100+ businesses

SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.

Policies

About

Support
Our Team
Affiliate Program
Privacy
Media

Navigation

Family Plan 👪
Gift SelfDecode 🎁
Analyze Bloodwork 🧪
Buy Individual Reports 🛒
Upload Your DNA File 🧬
Register My Kit
Careers
About
Login

WGS vs Genotyping: What's the Difference?

Feature	Whole Genome Sequencing (30x)	Standard DNA Genotyping
DNA Coverage	100% of genome (3B+ base pairs)	~0.02% (~650K SNPs)
Rare Variants	Detects rare and novel variants	Misses most rare variants
Structural Variants	Detects insertions, deletions, CNVs	Cannot detect
Pharmacogenomics	Comprehensive drug response data	Limited panel
Future-Proof	Raw data reanalyzable as science advances	Limited to pre-selected markers
Accuracy (Read Depth)	30x average coverage	Single read per variant

Why Choose SelfDecode for Whole Genome Sequencing?

AI-Powered Health Reports

Get 30+ personalized health reports powered by AI that analyze your genetic data alongside the latest peer-reviewed research to provide actionable health recommendations.

30x Coverage Accuracy

Every position in your genome is read an average of 30 times, ensuring 99.9%+ accuracy for SNPs and reliable detection of structural variants that other tests miss.

Raw Data Access

Download your complete raw genome data in standard VCF/BAM formats. Your data is yours to keep and can be reanalyzed as new genetic discoveries emerge.

Physician-Shareable Reports

Generate professional reports formatted for healthcare providers, making it easy to discuss your genetic insights with your doctor for personalized care decisions.

Share Your Results with Your Doctor

SelfDecode generates physician-friendly reports that translate complex genetic data into actionable clinical insights. Share your personalized health reports directly with your healthcare provider to support informed, precision-medicine decisions.

Our reports include relevant gene variants, risk scores, and evidence-based recommendations that doctors can use alongside your clinical history.

Frequently Asked Questions About Whole Genome Sequencing

What is whole genome sequencing?

Whole genome sequencing (WGS) reads all 3 billion base pairs of your DNA, providing complete coverage of your entire genetic code. Unlike genotyping chips that only test a small fraction of pre-selected markers, WGS captures every variant including rare mutations, structural changes, and insertions/deletions that standard tests miss.

How is 30x whole genome sequencing different from standard DNA tests?

30x coverage means every base pair of your DNA is read an average of 30 times, ensuring extremely high accuracy (99.9%+). Standard DNA genotyping tests like those from 23andMe or AncestryDNA only read about 0.02% of your genome using pre-selected SNP chips, missing the vast majority of genetic variants.

How much does whole genome sequencing cost?

SelfDecode offers whole genome sequencing with comprehensive health analysis. The cost includes not just the sequencing itself, but also AI-powered health reports, personalized recommendations, and lifetime access to your raw genetic data. Visit our pricing page for current offers and packages.

How long does it take to get whole genome sequencing results?

After your DNA sample arrives at our lab, whole genome sequencing and analysis typically takes 8-12 weeks. You will receive a notification when your results are ready to view in your SelfDecode dashboard, along with all personalized health reports and recommendations.

Can I share my WGS results with my doctor?

Yes. SelfDecode provides physician-shareable reports specifically designed for healthcare providers. These reports present your genetic data in a clinical format with relevant variants, risk assessments, and evidence-based recommendations that help your doctor make more informed treatment decisions.

What can whole genome sequencing tell me about my health?

WGS can reveal insights about disease risk factors, drug metabolism (pharmacogenomics), carrier status for inherited conditions, nutritional needs based on genetic variants, and much more. With SelfDecode's AI analysis, you get personalized health reports covering 30+ health topics with actionable recommendations.

Is my genetic data secure with SelfDecode?

SelfDecode takes data security seriously. Your genetic data is encrypted, stored securely, and never sold to third parties. You maintain full ownership and control of your data, including the ability to download or delete it at any time.

Health reports

High Blood Sugar
Anxiety
Gluten Sensitivity
Gut Inflammation
Blood Pressure
IBS
Mood
Insomnia
PTSD
Mood Swings
Overweight
Memory Performance
Sexual Dysfunction
PCOS
Psoriasis
Joint Pain
Attention/ADHD
Chronic Fatigue / Tiredness
Allergies
Asthma
Acne
Tinnitus
Eczema
Food Allergy
Vitamin B6
Vitamin E
Restless Leg Syndrome
Grinding Teeth
Vitamin A
Magnesium
Zinc
Heart Health
Migraines
(High) Cholesterol
Headache
Chronic Pain
Back pain
Shoulder & Neck Pain
Stress
Inflammation
Omega-3 needs
Salt Sensitivity
Endurance
Power performance
Strength
Exercise recovery
Brain Fog
Female Fertility
Longevity
Addiction
Erectile Dysfunction
Male Infertility
MTHFR
Joint Inflammation
GERD
Ulcers
Sleep Apnea
Periodontitis
Varicose Veins
H. pylori
Liver Health
Canker Sores
Gallstones
Kidney Health
Gout
Hair Loss (Male-Pattern Baldness)
Riboflavin
Urticaria
Rosacea
Carpal Tunnel Syndrome
Sinus Congestion
Cavities
Artery Hardening
Vertigo
Vitiligo
Myopia
Indigestion
Excessive Sweating
Testosterone – Males
Yeast infection (Candida)
Endometriosis
Tobacco addiction
Alcohol addiction
Uterine fibroids
Length of menstrual cycle
UTI
OCD
Kidney Stones
Vitamin B12
Vitamin C
Vitamin D
Folate
Iron
Eating Disorders
Bone Health
Hypothyroidism
Hyperthyroidism
Sugar Cravings
Hearing/difficulty problem /Hearing loss
Painful Periods
Palpitations
Hemorrhoids
Hypotension
Bladder Control
Constipation
Appendicitis
Low Blood Sugar
Irregular Periods
Metabolic rate
Visceral fat
Lung Health
Anemia
Calcium
Cognition
Cognitive Decline
Seasonal Low Mood
Vitamin K
Phosphate
HRV
Cluster headaches
Knee Pain
Hip Pain
Selenium
Low back injury
Dyslexia
Cannabis addiction
Histamine Intolerance
Carnitine
Pesticide Sensitivity
Organophosphate Sensitivity
Cadmium
Lead
Melatonin
FSH
T4
T3
High PTH
Potassium
Coenzyme Q10 (CoQ10)
Chromium
Oxalate Sensitivity
Salicylate Sensitivity
Facial Wrinkles
Age Spots
Ligament Rupture (ACL Injury)
Tendon Injury (Tendinopathy)
Omega 6
Omega 6:Omega 3 Ratio
Arachidonic Acid
Oleic Acid
Alpha-Linolenic Acid
EPA
GLA
Linoleic Acid
DHA
Insulin Resistance
Sperm Motility
Homocysteine
C difficile
Pneumonia
EBV Infection
Gastrointestinal Infection
Chronic Bronchitis
Copper
Skin Elasticity
Skin Hydration
Egg allergy
ApoB
GGT
TIBC
Bioavailable Testosterone (Male)
MPV
Chloride
Free T4
Processing Speed
Short-term memory
TMAO
Air pollution sensitivity
Heart Rate
VO2 Max
Flu
Hair graying
Caffeine-Related Sleep Problems
Groin Hernia
Stretch marks
Droopy Eyelids
Strep infection
Dry eyes
Carbohydrate Consumption
Peanut allergy
Heart rate recovery
Muscle recovery
Jaw Disorders
HPV Infection
Acute Bronchitis
Chlamydia
Genital Herpes
Pancreas inflammation
Executive Function
Pyroglutamic acid
Raynaud’s
Liver Scarring
Dandruff
Bioavailable Testosterone (Female)
Shrimp allergy
Haptoglobin
Milk allergy
Beta-Alanine
Taurine
LDL Particle Size
Diarrhea
Snoring
Uric acid
Phenylalanine
Leucine
Glutamine
Valine
Glycine
Alanine
Lysine
Arginine
Histidine
Tyrosine
Cortisol
DHEAS
Insulin
Prolactin
TSH
Lactate
Ketone Bodies
IL-17A (Th17 Dominance)
Creatine Kinase
Neutrophils
Basophils
Eosinophils
Ferritin
ALT
AST
MCV
Hematocrit
RDW
SHBG
Total Protein
Albumin
MCH
Sodium
MCHC
Alkaline Phosphatase
Monocytes
Ghrelin
IL10 (Th2)
IL-6 (Th2 and Th17)
Iodine
Chili Pepper sensitivity
COMT
DRD2 (Dopamine)
Lectin Sensitivity
Thiamine
Biotin
Mold Sensitivity (Foodborne)
Chronic Lyme
BDNF
Glyphosate sensitivity
BPA Sensitivity
Pregnenolone
Luteinizing Hormone (LH)
Growth Hormone
IgA
Molybdenum
Sensitivity to Dairy (IgG Casein)
Telomere Length
Serotonin (5HIAA)
Non-Celiac Gluten Sensitivity (IgG Gliadin)
Manganese
Klotho
Mold Sensitivity (Airborne)
Amylase
Lipase
Low Sperm Count
Tryptophan
Methionine
Glutamate
Proline
Blood Calcium
Hypertriglyceridemia
HDL Cholesterol
HbA1c
Hemoglobin
Total Cholesterol
LDL Cholesterol
IGF1
Fasting Glucose
Bilirubin (total)
White blood cell count
Red blood cell count
Platelets
eGFR
Creatinine
Estradiol
Neuroticism
Sleep Quality
Lactose Intolerance
Saturated fat
Optimal diet
Unsaturated fat
Achilles tendon injury
Deep sleep
Fat
Response to Stress
Leadership
Ankle injury
Creativity
Hoarding
Protein
Optimal Exercise
Knee Injury
Rotator cuff injury
Extraversion
Risk-Taking
Happiness
Daytime Sleepiness
Morningness
Time spent watching TV
Disliking cilantro
Alcohol Sensitivity
Response to Caffeine
Snacking
Weight Regain
Sleep movement
Wearing glasses or contacts
Educational Attainment
Bitter Taste Sensitivity
Agreeableness
Aggression
Conscientiousness
Openness to experience
Physical activity
Caffeine-Related Anxiety
Naps