rs7528684

Chromosome : 1 , Position: 157701026

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: A

Alternative Alleles: G, T, C

Associated Genes

FCRL3

FCRL1

FCRL4

FCRL5

FCRL2

CD5L

KIRREL1

SMIM42

CD1D

Traits

Trait	Variant	Impact	PMID	Author (year)
Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes	G		PLoS Genet	Plagnol V (2011)

Summary

rs7528684 has been reported to be associated with rheumatoid arthritis in a Caucasian population, following reports of a similar association in a Japanese population. [rheumatoid arthritis: OR = 2.15 (CI = 1.58â€“2.93), from 830 cases and 658 controls;

for SLE: OR = 1.49 (CI = 1.16â€“1.92), from 564 cases;

for Graves’ disease : OR = 1.79 (CI = 1.34â€“2.39), from 351 cases;

for Hashimoto thyroiditis: OR = 1.62 (CI = 1.07â€“2.47), from 158 cases.

[rheumatoid arthritis

[SLE) in a study of 248 Chinese Han patients.

[PMID 19438904] Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves’ disease

[PMID 21885492] FCRL3 -169C/C Genotype Is Associated with Anti-citrullinated Protein Antibody-positive Rheumatoid Arthritis and with Radiographic Progression

[PMID 16519819] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16859508] Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?

[PMID 17389014] Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD.

[PMID 18556337] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

[PMID 18759263] Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.

[PMID 19050767] Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet’s disease in a Chinese population with ophthalmic manifestations.

[PMID 19180233] Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.

[PMID 19452015] Polymorphisms of FCRL3 in a Chinese population with Vogt-Koyanagi-Harada (VKH) syndrome.

[PMID 19877046] The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells.

[PMID 22341374] Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis.

[PMID 23505439] A Refined Study of FCRL Genes from a Genome-Wide Association Study for Graves’ Disease

[PMID 23512175] Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and systemic lupus erythematosus: a meta-analysis

[PMID 24117236] The Fc receptor-like 3 gene polymorphisms and susceptibility to autoimmune diseases: An updated meta-analysis

[PMID 23564408] The FCRL3 -169T>C polymorphism might be associated with some autoantibody presence in patients with SLE in a Polish population.

[PMID 26051414] FCRL3 gene polymorphisms confer risk for sudden sensorineural hearing loss in a Chinese Han Population

[PMID 25566937] A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis

More Information

rs7528684 is a SNP of the FCRL3 gene. It is significantly associated with autoimmune diseases (ADs).

rs7528684 (no reported alleles) was significantly associated with sudden sensorineural hearing loss (SSNHL) in a Chinese Han population [R].

The ''G'' allele associated with Systemic lupus erythamosus (SLE) and rheumatoid arthritis (RA) risk [R].

The ''AA'' genotype was associated with a reduced risk of Graves' disease (GD) [R].

Patients with ulcerative colitis (UC) by human leukocyte antigen (HLA) showed a significant increase in heterozygous AG genotype (AG vs AA+GG, P= 0.0027, odds ratio = 3.6) [R].

G/A was associated with autoimmune thyroid disease (AITD) and systemic lupus erythematosus (SLE) [R].

A positive association was found between the ''AA' genotype and the risk of endometriosis development. Moreover, a progression of the disease risk was observed according to the presence of one or two copies of risk allele ''G'' (OR = 2.14, OR = 3.25, and OR = 6.0, respectively for genotypes AA, GA and GG) [R].

The ''G'' allele was associated with Graves' disease (GD) risk [R].

The AG, AA+AG genotypes contributed to a lower risk of human autoimmune diseases (ADs), compared with the GG carriers (OR = 0.91; OR = 0.91) [R].

Population Alleles Frequency

ethhicity frequency	G	T	C
African/African-American	0.8708	–	–
Latino/Admixed American	0.4858	–	–
Ashkenazi Jewish	0.4167	–	–
East Asian	0.3973	–	–
European	0.421	–	–
Other (population not assigned)	0.4353	–	–

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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