High Blood Sugar
Anxiety
Gluten Sensitivity
Gut Inflammation
Blood Pressure
IBS
Mood
Insomnia
PTSD
Mood Swings
Overweight
Memory Performance
Sexual Dysfunction
PCOS
Psoriasis
Joint Pain
Attention/ADHD
Chronic Fatigue / Tiredness
Allergies
Asthma
Acne
Tinnitus
Eczema
Food Allergy
Vitamin B6
Vitamin E
Restless Leg Syndrome
Grinding Teeth
Vitamin A
Magnesium
Zinc
Heart Health
Migraines
(High) Cholesterol
Headache
Chronic Pain
Back pain
Shoulder & Neck Pain
Stress
Inflammation
Omega-3 needs
Salt Sensitivity
Endurance
Power performance
Strength
Exercise recovery
Brain Fog
Female Fertility
Longevity
Addiction
Erectile Dysfunction
Male Infertility
MTHFR
Joint Inflammation
GERD
Ulcers
Sleep Apnea
Periodontitis
Varicose Veins
H. pylori
Liver Health
Canker Sores
Gallstones
Kidney Health
Gout
Hair Loss (Male-Pattern Baldness)
Riboflavin
Urticaria
Rosacea
Carpal Tunnel Syndrome
Sinus Congestion
Cavities
Artery Hardening
Vertigo
Vitiligo
Myopia
Indigestion
Excessive Sweating
Testosterone – Males
Yeast infection (Candida)
Endometriosis
Tobacco addiction
Alcohol addiction
Uterine fibroids
Length of menstrual cycle
UTI
OCD
Kidney Stones
Vitamin B12
Vitamin C
Vitamin D
Folate
Iron
Eating Disorders
Bone Health
Hypothyroidism
Hyperthyroidism
Sugar Cravings
Hearing/difficulty problem /Hearing loss
Painful Periods
Palpitations
Hemorrhoids
Hypotension
Bladder Control
Constipation
Appendicitis
Low Blood Sugar
Irregular Periods
Metabolic rate
Visceral fat
Lung Health
Anemia
Calcium
Cognition
Cognitive Decline
Seasonal Low Mood
Vitamin K
Phosphate
HRV
Cluster headaches
Knee Pain
Hip Pain
Selenium
Low back injury
Dyslexia
Cannabis addiction
Histamine Intolerance
Carnitine
Pesticide Sensitivity
Organophosphate Sensitivity
Cadmium
Lead
Melatonin
FSH
T4
T3
High PTH
Potassium
Coenzyme Q10 (CoQ10)
Chromium
Oxalate Sensitivity
Salicylate Sensitivity
Facial Wrinkles
Age Spots
Ligament Rupture (ACL Injury)
Tendon Injury (Tendinopathy)
Omega 6
Omega 6:Omega 3 Ratio
Arachidonic Acid
Oleic Acid
Alpha-Linolenic Acid
EPA
GLA
Linoleic Acid
DHA
Insulin Resistance
Sperm Motility
Homocysteine
C difficile
Pneumonia
EBV Infection
Gastrointestinal Infection
Chronic Bronchitis
Copper
Skin Elasticity
Skin Hydration
Egg allergy
ApoB
GGT
TIBC
Bioavailable Testosterone (Male)
MPV
Chloride
Free T4
Processing Speed
Short-term memory
TMAO
Air pollution sensitivity
Heart Rate
VO2 Max
Flu
Hair graying
Caffeine-Related Sleep Problems
Groin Hernia
Stretch marks
Droopy Eyelids
Strep infection
Dry eyes
Carbohydrate Consumption
Peanut allergy
Heart rate recovery
Muscle recovery
Jaw Disorders
HPV Infection
Acute Bronchitis
Chlamydia
Genital Herpes
Pancreas inflammation
Executive Function
Pyroglutamic acid
Raynaud’s
Liver Scarring
Dandruff
Bioavailable Testosterone (Female)
Shrimp allergy
Haptoglobin
Milk allergy
Beta-Alanine
Taurine
LDL Particle Size
Diarrhea
Snoring
Uric acid
Phenylalanine
Leucine
Glutamine
Valine
Glycine
Alanine
Lysine
Arginine
Histidine
Tyrosine
Cortisol
DHEAS
Insulin
Prolactin
TSH
Lactate
Ketone Bodies
IL-17A (Th17 Dominance)
Creatine Kinase
Neutrophils
Basophils
Eosinophils
Ferritin
ALT
AST
MCV
Hematocrit
RDW
SHBG
Total Protein
Albumin
MCH
Sodium
MCHC
Alkaline Phosphatase
Monocytes
Ghrelin
IL10 (Th2)
IL-6 (Th2 and Th17)
Iodine
Chili Pepper sensitivity
COMT
DRD2 (Dopamine)
Lectin Sensitivity
Thiamine
Biotin
Mold Sensitivity (Foodborne)
Chronic Lyme
BDNF
Glyphosate sensitivity
BPA Sensitivity
Pregnenolone
Luteinizing Hormone (LH)
Growth Hormone
IgA
Molybdenum
Sensitivity to Dairy (IgG Casein)
Telomere Length
Serotonin (5HIAA)
Non-Celiac Gluten Sensitivity (IgG Gliadin)
Manganese
Klotho
Mold Sensitivity (Airborne)
Amylase
Lipase
Low Sperm Count
Tryptophan
Methionine
Glutamate
Proline
Blood Calcium
Hypertriglyceridemia
HDL Cholesterol
HbA1c
Hemoglobin
Total Cholesterol
LDL Cholesterol
IGF1
Fasting Glucose
Bilirubin (total)
White blood cell count
Red blood cell count
Platelets
eGFR
Creatinine
Estradiol
Neuroticism
Sleep Quality
Lactose Intolerance
Saturated fat
Optimal diet
Unsaturated fat
Achilles tendon injury
Deep sleep
Fat
Response to Stress
Leadership
Ankle injury
Creativity
Hoarding
Protein
Optimal Exercise
Knee Injury
Rotator cuff injury
Extraversion
Risk-Taking
Happiness
Daytime Sleepiness
Morningness
Time spent watching TV
Disliking cilantro
Alcohol Sensitivity
Response to Caffeine
Snacking
Weight Regain
Sleep movement
Wearing glasses or contacts
Educational Attainment
Bitter Taste Sensitivity
Agreeableness
Aggression
Conscientiousness
Openness to experience
Physical activity
Caffeine-Related Anxiety
Naps
rs429358
Chromosome
: 19 , Position: 44908684
Most conditions are affected by anywhere from hundreds to millions of
genetic variants (SNPs). A single SNP usually has a minor contribution to
a person’s overall genetic risk for a certain condition. That is why you
shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to
determine polygenic risk scores (PRSs), which are the basis of most health
reports.
Reference Allele: T
Alternative Alleles:
C
Traits
| Trait | Variant | Impact | PMID | Author (year) |
|---|---|---|---|---|
| Alanine aminotransferase levels | C |
|
Nat Commun | Chen VL (2021) |
| White matter hyperintensities | C |
|
Nat Commun | Persyn E (2020) |
| Time to complete round | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Platelet count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Neurofibrillary tangles | C |
|
Brain | Dumitrescu L (2019) |
| Alzheimer's disease or family history of Alzheimer's disease | C |
|
Nat Genet | Schwartzentruber J (2021) |
| Neuritic plaque | C |
|
Brain | Dumitrescu L (2019) |
| Parental lifespan | C |
|
Elife | Timmers PR (2019) |
| Parental lifespan [EA] | C |
|
Nat Commun | Joshi PK (2017) |
| Cerebrospinal AB1-42 levels in normal cognition | C |
|
Alzheimers Dement | Chung J (2017) |
| Cerebrospinal fluid AB1-42 levels | C |
|
Alzheimers Dement | Chung J (2017) |
| Cerebrospinal AB1-42 levels in mild cognitive impairment | C |
|
Alzheimers Dement | Chung J (2017) |
| Amyloid pathology | C |
|
Transl Psychiatry | Hong S (2020) |
| Cerebrospinal fluid t-tau levels in mild cognitive impairment | C |
|
Alzheimers Dement | Chung J (2017) |
| Cerebrospinal fluid t-tau levels | C |
|
Alzheimers Dement | Chung J (2017) |
| Cerebrospinal fluid p-tau levels in mild cognitive impairment | C |
|
Alzheimers Dement | Chung J (2017) |
| Cerebrospinal fluid p-tau levels | C |
|
Alzheimers Dement | Chung J (2017) |
| Lewy body disease [Ordinal II] | C |
|
PLoS Genet | Beecham GW (2014) |
| Lewy body disease [Ordinal I] | C |
|
PLoS Genet | Beecham GW (2014) |
| Lewy body disease [Case/control] | C |
|
PLoS Genet | Beecham GW (2014) |
| Hippocampal volume | C |
|
Alzheimers Dement | Chung J (2017) |
| Logical memory (delayed recall) | C |
|
Alzheimers Dement | Chung J (2017) |
| Parkinson's disease progression (cognitive) | C |
|
Mov Disord | Tan MMX (2020) |
| Logical memory (immediate recall) | C |
|
Alzheimers Dement | Chung J (2017) |
| Parkinson's disease progression (composite) | C |
|
Mov Disord | Tan MMX (2020) |
| High-sensitivity C-reactive protein levels in HIV infection | C |
|
AIDS | Sherman BT (2020) |
| Neurofibrillary tangles [EA] | C |
|
Mol Psychiatry | Chibnik LB (2017) |
| C-reactive protein levels | C |
|
Eur J Epidemiol | Han X (2020) |
| Mean reticulocyte volume | C |
|
Unknown journal | UKB Neale v2 (2018) |
| C-reactive protein levels [BMI-adjusted] | C |
|
Am J Hum Genet | Ligthart S (2018) |
| Plasma amyloid beta peptide concentration (ABx-40/ABx-42 ratio) | C |
|
Alzheimers Dement | Damotte V (2021) |
| Mean sphered cell volume | C |
|
Unknown journal | UKB Neale v2 (2018) |
| LDL cholesterol | C |
|
Sci Rep | Prins BP (2017) |
| Cerebral amyloid deposition (PET imaging) | C |
|
Mol Psychiatry | Yan Q (2018) |
| Plasma amyloid beta peptide concentrations (ABx-42) | C |
|
Alzheimers Dement | Damotte V (2021) |
| Total cholesterol levels [East Asian] | C |
|
Nat Genet | Hoffmann TJ (2018) |
| Serum type 1 collagen metabolite levels | C |
|
Neurol Genet | Tang ME (2020) |
| Leg fat percentage (right) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Leg fat percentage (left) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Central cerebrospinal fluid amyloid beta 42 levels | C |
|
Transl Psychiatry | Hong S (2020) |
| Central cerebrospinal fluid amyloid beta 42 to 40 ratio | C |
|
Transl Psychiatry | Hong S (2020) |
| Apolipoprotein A1 levels | C |
|
PLoS Med | Richardson TG (2020) |
| Spherical equivalent | C |
|
JAMA Ophthalmol | Han X (2020) |
| HDL cholesterol levels | C |
|
PLoS Med | Richardson TG (2020) |
| Liver fat content (MRI proton density fat fraction measure) | C |
|
J Hepatol | Parisinos CA (2020) |
| Type 2 diabetes | C |
|
Nat Genet | Vujkovic M (2020) |
| Family history of Alzheimer's disease | C |
|
Nat Genet | Schwartzentruber J (2021) |
| HDL cholesterol | C |
|
Nat Genet | Surakka I (2015) |
| Red cell distribution width | C |
|
Cell | Vuckovic D (2020) |
| Parental longevity (combined parental attained age, Martingale residuals) | C |
|
Aging (Albany NY) | Pilling LC (2017) |
| Parental longevity (mother's attained age) | C |
|
Aging (Albany NY) | Pilling LC (2017) |
| Mean spheric corpuscular volume | C |
|
Cell | Vuckovic D (2020) |
| Number of days/week of moderate physical activity 10+ minutes | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Parental longevity (combined parental age at death) | C |
|
Aging (Albany NY) | Pilling LC (2017) |
| Leg fat mass (left) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Red blood cell (erythrocyte) distribution width | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Plateletcrit | C |
|
Cell | Vuckovic D (2020) |
| Number of days/week of vigorous physical activity 10+ minutes | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Parental longevity (mother's age at death) | C |
|
Aging (Albany NY) | Pilling LC (2017) |
| Parental longevity (father's attained age) | C |
|
Aging (Albany NY) | Pilling LC (2017) |
| Parental longevity (father's age at death) | C |
|
Aging (Albany NY) | Pilling LC (2017) |
| Serum 25-Hydroxyvitamin D levels | C |
|
Nat Commun | Revez JA (2020) |
| Dried fruit intake | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Cereal intake | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Moderate to vigorous physical activity levels | C |
|
Int J Obes (Lond) | Klimentidis YC (2018) |
| Weight change compared with 1 year ago | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Water intake | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Salt added to food | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Adult body size | C |
|
BMJ | Richardson TG (2020) |
| Lamb/mutton intake | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Pork intake | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Mental health study participation (completed survey) | C |
|
Int J Epidemiol | Adams MJ (2019) |
| Fresh fruit intake | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Liver enzyme levels (alanine transaminase) | C |
|
Nat Commun | Pazoki R (2021) |
| Insulin-like growth factor 1 levels | C |
|
Elife | Sinnott-Armstrong N (2021) |
| Liver enzyme levels (alkaline phosphatase) | C |
|
Nat Commun | Pazoki R (2021) |
| Platelet crit | C |
|
Unknown journal | UKB Neale v2 (2018) |
| "Alzheimer disease, including avohilmo" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Any mental disorder, or suicide (or attempt), or psychic disorders complicating pregnancy, partum or puerperum or nerve system disorders" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Delirium, not induced by alcohol and other psychoactive substances" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Diabetes, insuline treatment (Kela reimbursement)" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Diabetes, insuline treatment (Kela reimbursement)" (more controls excluded) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Diabetes, varying definitions" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Organic, including symptomatic, mental disorders" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Other diabetes, wide definition" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Symptoms and signs involving cognition, perception, emotional state and behaviour" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 2 diabetes, definitions combined" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 2 diabetes, strict (exclude DM1)" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Abdominal aortic aneurysm | C |
|
Circulation | Klarin D (2020) |
| Acceptance of an invitation to participate in a mental health questionnaire | C |
|
Nat Commun | Tyrrell J (2021) |
| Adult onset asthma or type 2 diabetes | C |
|
J Allergy Clin Immunol | Zhu Z (2019) |
| Advanced age-related macular degeneration [EA] | C |
|
Nat Genet | Fritsche LG (2015) |
| Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) | C |
|
Nat Commun | Timmers PRHJ (2020) |
| Altered mental status | C |
|
Unknown journal | UKB SAIGE (2018) |
| Alzheimer disease | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Alzheimer disease (more controls excluded) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Alzheimer's disease | C |
|
Alzheimers Dement | Moreno-Grau S (2019) |
| Alzheimer's disease (onset at age over 80) | C |
|
Neurobiol Aging | Lo MT (2019) |
| Alzheimer's disease (onset between ages 58 and 79) | C |
|
Neurobiol Aging | Lo MT (2019) |
| Alzheimer's disease [females] | C |
|
Alzheimers Res Ther | Nazarian A (2019) |
| Alzheimer's disease [males] | C |
|
Alzheimers Res Ther | Nazarian A (2019) |
| Alzheimer's disease biomarkers [Cortical Ab] | C |
|
Mol Psychiatry | Ramanan VK (2013) |
| Alzheimer's disease in hypertension | C |
|
Geroscience | Nazarian A (2019) |
| Alzheimer's disease in hypertension-negative individuals | C |
|
Geroscience | Nazarian A (2019) |
| Alzheimer's disease progression score [uncorrected for APOE4 status and baseline cortical amyloid] | C |
|
Brain | Scelsi MA (2018) |
| Alzheimer's disease/dementia | illnesses of father | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Alzheimer's disease/dementia | illnesses of mother | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Alzheimer's disease/dementia | illnesses of siblings | C |
|
Unknown journal | UKB Neale v2 (2018) |
| AlzheimerÕs disease (Atypical or mixed) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| AlzheimerÕs disease (Atypical or mixed) (more controls excluded) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| AlzheimerÕs disease (Early onset) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| AlzheimerÕs disease (Early onset) (more controls excluded) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| AlzheimerÕs disease (Late onset) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| AlzheimerÕs disease (Late onset) (more controls excluded) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| AlzheimerÕs disease (undefined) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| AlzheimerÕs disease (undefined) (more controls excluded) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Alzheimer’s disease (clinical subgroup AD+) | C |
|
Alzheimers Dement | Moreno-Grau S (2019) |
| Alzheimer’s disease (clinical subgroup AD++) | C |
|
Alzheimers Dement | Moreno-Grau S (2019) |
| Alzheimer’s disease (clinical subgroup AD+++) | C |
|
Alzheimers Dement | Moreno-Grau S (2019) |
| Alzheimer’s disease and/or vascular dementia (clinical subgroup VaD+) | C |
|
Alzheimers Dement | Moreno-Grau S (2019) |
| Amyloid status (abnormal vs normal) | C |
|
Transl Psychiatry | Hong S (2020) |
| Angina pectoris | C |
|
Unknown journal | UKB SAIGE (2018) |
| Any dementia | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Any dementia (more controls excluded) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Any mental disorder | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Atorvastatin | treatment/medication code | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Blood protein levels [EA, Apolipoprotein E] | C |
|
Nat Commun | Suhre K (2017) |
| Brain imaging [grey matter density of the right hippocampus] | C |
|
Neuroimage | Shen L (2010) |
| Butter/spreadable butter | spread type | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Central cerebrospinal fluid amyloid beta 42 to 40 ratio (abnormal vs normal) | C |
|
Transl Psychiatry | Hong S (2020) |
| Cerebral amyloid angiopathy [EA] | C |
|
Mol Psychiatry | Chibnik LB (2017) |
| Cerebral amyloid deposition positivity (PET imaging) | C |
|
PLoS One | Li QS (2015) |
| Cerebrospinal AB1-42 levels in Alzheimer's disease dementia | C |
|
Hum Mol Genet | Ramirez A (2014) |
| Cholesterol lowering medication | medication for cholesterol, blood pressure or diabetes | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Cholesterol lowering medication | medication for cholesterol, blood pressure, diabetes, or take exogenous hormones | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Codeine or tramadol medication | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Cognitive decline (age-related) | C |
|
Neurol Genet | Raj T (2016) |
| Coronary artery disease | C |
|
Circ Res | van der Harst P (2017) |
| Coronary atherosclerosis | C |
|
Unknown journal | UKB SAIGE (2018) |
| Cortical amyloid beta load [uncorrected for APOE4 status] | C |
|
Brain | Scelsi MA (2018) |
| Delirium dementia and amnestic and other cognitive disorders | C |
|
Unknown journal | UKB SAIGE (2018) |
| Delirium due to conditions classified elsewhere | C |
|
Unknown journal | UKB SAIGE (2018) |
| Dementia in Alzheimer disease | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Dementia with Lewy bodies | C |
|
Sci Rep | Rongve A (2019) |
| Dementias | C |
|
Unknown journal | UKB SAIGE (2018) |
| Diabetes mellitus | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Diabetes | illnesses of father | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Diabetes | illnesses of mother | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Diffuse plaques [EA] | C |
|
Mol Psychiatry | Chibnik LB (2017) |
| Disorders of lipoid metabolism | C |
|
Unknown journal | UKB SAIGE (2018) |
| Executive function (trail making test B) | C |
|
Nat Hum Behav | de la Fuente J (2020) |
| Ezetrol 10mg tablet | treatment/medication code | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Father still alive | C |
|
Unknown journal | UKB Neale v2 (2018) |
| HDL cholesterol levels x short total sleep time interaction (2df test) | C |
|
Nat Commun | Noordam R (2019) |
| High blood pressure | illnesses of mother | C |
|
Unknown journal | UKB Neale v2 (2018) |
| High cholesterol | non-cancer illness code, self-reported | C |
|
Unknown journal | UKB Neale v2 (2018) |
| High density lipoprotein cholesterol levels | C |
|
Nat Genet | Kanai M (2018) |
| Hippocampal volume [uncorrected for APOE4 status] | C |
|
Brain | Scelsi MA (2018) |
| Hypercholesterolemia | C |
|
Unknown journal | UKB SAIGE (2018) |
| Hyperlipidemia | C |
|
Unknown journal | UKB SAIGE (2018) |
| Information processing speed (symbol digit substitution) | C |
|
Nat Hum Behav | de la Fuente J (2020) |
| Insomnia | C |
|
Nat Genet | Jansen PR (2019) |
| Lamb consumption | C |
|
Transl Psychiatry | Niarchou M (2020) |
| Lipitor 10mg tablet | treatment/medication code | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Longevity (age >90th survival percentile) | C |
|
Nat Commun | Deelen J (2019) |
| Longevity (age >99th survival percentile) | C |
|
Nat Commun | Deelen J (2019) |
| Low density lipoprotein cholesterol levels | C |
|
Nat Genet | Kanai M (2018) |
| Maternal history of Alzheimer's disease | C |
|
Transl Psychiatry | Marioni RE (2018) |
| Meat-related diet | C |
|
Transl Psychiatry | Niarchou M (2020) |
| Meat-related diet [female] | C |
|
Transl Psychiatry | Niarchou M (2020) |
| Memory loss | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Mortality | C |
|
Nat Commun | Joshi PK (2016) |
| Mother still alive | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Myocardial infarction | C |
|
Eur Heart J | Hartiala JA (2021) |
| Neuritic plaque [EA] | C |
|
Mol Psychiatry | Chibnik LB (2017) |
| Neuritic plaques or cerebral amyloid angiopathy (pleiotropy) | C |
|
Alzheimers Res Ther | Chung J (2018) |
| Neuritic plaques or neurofibrillary tangles (pleiotropy) | C |
|
Alzheimers Res Ther | Chung J (2018) |
| Neurofibrillary tangles or cerebral amyloid angiopathy (pleiotropy) | C |
|
Alzheimers Res Ther | Chung J (2018) |
| Neurological diseases | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Neurological disorders | C |
|
Unknown journal | UKB SAIGE (2018) |
| Neuropathologic traits (pleiotropy) [EA] | C |
|
Mol Psychiatry | Chibnik LB (2017) |
| No | major dietary changes in the last 5 years | C |
|
Unknown journal | UKB Neale v2 (2018) |
| None of the above | medication for cholesterol, blood pressure or diabetes | C |
|
Unknown journal | UKB Neale v2 (2018) |
| None of the above | medication for cholesterol, blood pressure, diabetes, or take exogenous hormones | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Other (e.g. cornflakes, frosties) | cereal type | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Other degenerative diseases of the nervous system | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Other mental disorders due to brain damage and dysfunction and to physical disease | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Other symptoms and signs involving cognitive functions and awareness | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Other type of spread/margarine | spread type | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Parental longevity (both parents in top 10%) | C |
|
Aging (Albany NY) | Pilling LC (2017) |
| Parental longevity (mother's age at death or mother's attained age) | C |
|
G3 (Bethesda) | Wright KM (2019) |
| Paternal history of Alzheimer's disease | C |
|
Transl Psychiatry | Marioni RE (2018) |
| Percent liver fat | C |
|
Elife | Liu Y (2021) |
| Psychiatric diseases | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Ratio of apolipoprotein A1 to apolipoprotein B | C |
|
PLoS Genet | Davis JP (2017) |
| Refractive error | C |
|
Nat Genet | Hysi PG (2020) |
| Relative sugar intake | C |
|
Mol Psychiatry | Meddens SFW (2020) |
| Serum C-reactive protein concentration | C |
|
Cancer Prev Res (Phila) | Jung SY (2020) |
| Simvastatin | treatment/medication code | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Suicide or other Intentional self-harm | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Total cholesterol levels | C |
|
Nat Genet | Kanai M (2018) |
| Type 2 diabetes with other specified/multiple/unspecified complications | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Type 2 diabetes without complications | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Undefined dementia | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Undefined dementia (more controls excluded) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Unspecified dementia | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Vascular dementia | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Vascular dementia (subcortical) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Vascular dementia (undefined) | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Waist-hip ratio | C |
|
Am J Hum Genet | Kichaev G (2018) |
| Waist-to-hip ratio adjusted for BMI | C |
|
J Allergy Clin Immunol | Zhu Z (2019) |
| Wet age-related macular degeneration | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Yes, because of other reasons | major dietary changes in the last 5 years | C |
|
Unknown journal | UKB Neale v2 (2018) |
Summary
The C (minor) allele is associated with:
- One C = Bad version = Less APOE4.
- CT: >3x increased risk for Alzheimer's; 1.4x increased risk for heart disease
More Information
The C (minor) allele is associated with:
C = Bad version = predictive of APOE4
- rs429358(C;C) + rs7412 (C;C) = APOE4/APOE4 (Bad) = 12x for late-onset Alzheimer's and 61x for early-onset disease [R].
- rs429358(C;T) + rs7412 (C;C) = APOE4/APOE3 (Bad) = >3x increased risk for Alzheimer's; 1.4x increased risk for heart disease [R].
- rs429358(T;T) + rs7412 (C;C) = APOE3/APOE3 (Good)
If the allele of this SNP is "C" and the same chromosome also harbors the rs7412 "C" allele, the combination is known as an APOE-ε4 allele. The APOE-ε4 allele has a strong influence on the risk of Alzheimer's disease.
Many studies have estimated the level of risk, and it varies depending on age, sex, ethnicity, and other factors. One meta-analysis estimated the odds ratios for homozygous rs429358(C;C) individuals compared to the more common ApoE3/ApoE3 homozygotes to be 12x for late-onset Alzheimer's and 61x for early-onset disease [R].
Meta-analyses have also supported the association between the APOE-ε4 allele and somewhat increased risk for heart disease, with an odds ratio of 1.42 (CI: 1.26 – 1.61) [R].
The C allele is also reported to be associated with increased levels of physical activity [R]
Population Alleles Frequency
| ethhicity | frequency |
|---|---|
| African/African-American | 0.2122 |
| Latino/Admixed American | 0.1232 |
| Ashkenazi Jewish | 0.1042 |
| East Asian | 0.0969 |
| European | 0.1418 |
| Other (population not assigned) | 0.1596 |
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