High Blood Sugar
Anxiety
Gluten Sensitivity
Gut Inflammation
Blood Pressure
IBS
Mood
Insomnia
PTSD
Mood Swings
Overweight
Memory Performance
Sexual Dysfunction
PCOS
Psoriasis
Joint Pain
Attention/ADHD
Chronic Fatigue / Tiredness
Allergies
Asthma
Acne
Tinnitus
Eczema
Food Allergy
Vitamin B6
Vitamin E
Restless Leg Syndrome
Grinding Teeth
Vitamin A
Magnesium
Zinc
Heart Health
Migraines
(High) Cholesterol
Headache
Chronic Pain
Back pain
Shoulder & Neck Pain
Stress
Inflammation
Omega-3 needs
Salt Sensitivity
Endurance
Power performance
Strength
Exercise recovery
Brain Fog
Female Fertility
Longevity
Addiction
Erectile Dysfunction
Male Infertility
MTHFR
Joint Inflammation
GERD
Ulcers
Sleep Apnea
Periodontitis
Varicose Veins
H. pylori
Liver Health
Canker Sores
Gallstones
Kidney Health
Gout
Hair Loss (Male-Pattern Baldness)
Riboflavin
Urticaria
Rosacea
Carpal Tunnel Syndrome
Sinus Congestion
Cavities
Artery Hardening
Vertigo
Vitiligo
Myopia
Indigestion
Excessive Sweating
Testosterone – Males
Yeast infection (Candida)
Endometriosis
Tobacco addiction
Alcohol addiction
Uterine fibroids
Length of menstrual cycle
UTI
OCD
Kidney Stones
Vitamin B12
Vitamin C
Vitamin D
Folate
Iron
Eating Disorders
Bone Health
Hypothyroidism
Hyperthyroidism
Sugar Cravings
Hearing/difficulty problem /Hearing loss
Painful Periods
Palpitations
Hemorrhoids
Hypotension
Bladder Control
Constipation
Appendicitis
Low Blood Sugar
Irregular Periods
Metabolic rate
Visceral fat
Lung Health
Anemia
Calcium
Cognition
Cognitive Decline
Seasonal Low Mood
Vitamin K
Phosphate
HRV
Cluster headaches
Knee Pain
Hip Pain
Selenium
Low back injury
Dyslexia
Cannabis addiction
Histamine Intolerance
Carnitine
Pesticide Sensitivity
Organophosphate Sensitivity
Cadmium
Lead
Melatonin
FSH
T4
T3
High PTH
Potassium
Coenzyme Q10 (CoQ10)
Chromium
Oxalate Sensitivity
Salicylate Sensitivity
Facial Wrinkles
Age Spots
Ligament Rupture (ACL Injury)
Tendon Injury (Tendinopathy)
Omega 6
Omega 6:Omega 3 Ratio
Arachidonic Acid
Oleic Acid
Alpha-Linolenic Acid
EPA
GLA
Linoleic Acid
DHA
Insulin Resistance
Sperm Motility
Homocysteine
C difficile
Pneumonia
EBV Infection
Gastrointestinal Infection
Chronic Bronchitis
Copper
Skin Elasticity
Skin Hydration
Egg allergy
ApoB
GGT
TIBC
Bioavailable Testosterone (Male)
MPV
Chloride
Free T4
Processing Speed
Short-term memory
TMAO
Air pollution sensitivity
Heart Rate
VO2 Max
Flu
Hair graying
Caffeine-Related Sleep Problems
Groin Hernia
Stretch marks
Droopy Eyelids
Strep infection
Dry eyes
Carbohydrate Consumption
Peanut allergy
Heart rate recovery
Muscle recovery
Jaw Disorders
HPV Infection
Acute Bronchitis
Chlamydia
Genital Herpes
Pancreas inflammation
Executive Function
Pyroglutamic acid
Raynaud’s
Liver Scarring
Dandruff
Bioavailable Testosterone (Female)
Shrimp allergy
Haptoglobin
Milk allergy
Beta-Alanine
Taurine
LDL Particle Size
Diarrhea
Snoring
Uric acid
Phenylalanine
Leucine
Glutamine
Valine
Glycine
Alanine
Lysine
Arginine
Histidine
Tyrosine
Cortisol
DHEAS
Insulin
Prolactin
TSH
Lactate
Ketone Bodies
IL-17A (Th17 Dominance)
Creatine Kinase
Neutrophils
Basophils
Eosinophils
Ferritin
ALT
AST
MCV
Hematocrit
RDW
SHBG
Total Protein
Albumin
MCH
Sodium
MCHC
Alkaline Phosphatase
Monocytes
Ghrelin
IL10 (Th2)
IL-6 (Th2 and Th17)
Iodine
Chili Pepper sensitivity
COMT
DRD2 (Dopamine)
Lectin Sensitivity
Thiamine
Biotin
Mold Sensitivity (Foodborne)
Chronic Lyme
BDNF
Glyphosate sensitivity
BPA Sensitivity
Pregnenolone
Luteinizing Hormone (LH)
Growth Hormone
IgA
Molybdenum
Sensitivity to Dairy (IgG Casein)
Telomere Length
Serotonin (5HIAA)
Non-Celiac Gluten Sensitivity (IgG Gliadin)
Manganese
Klotho
Mold Sensitivity (Airborne)
Amylase
Lipase
Low Sperm Count
Tryptophan
Methionine
Glutamate
Proline
Blood Calcium
Hypertriglyceridemia
HDL Cholesterol
HbA1c
Hemoglobin
Total Cholesterol
LDL Cholesterol
IGF1
Fasting Glucose
Bilirubin (total)
White blood cell count
Red blood cell count
Platelets
eGFR
Creatinine
Estradiol
Neuroticism
Sleep Quality
Lactose Intolerance
Saturated fat
Optimal diet
Unsaturated fat
Achilles tendon injury
Deep sleep
Fat
Response to Stress
Leadership
Ankle injury
Creativity
Hoarding
Protein
Optimal Exercise
Knee Injury
Rotator cuff injury
Extraversion
Risk-Taking
Happiness
Daytime Sleepiness
Morningness
Time spent watching TV
Disliking cilantro
Alcohol Sensitivity
Response to Caffeine
Snacking
Weight Regain
Sleep movement
Wearing glasses or contacts
Educational Attainment
Bitter Taste Sensitivity
Agreeableness
Aggression
Conscientiousness
Openness to experience
Physical activity
Caffeine-Related Anxiety
Naps
rs3184504
Traits
| Trait | Variant | Impact | PMID | Author (year) |
|---|---|---|---|---|
| Basal metabolic rate | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Eosinophil counts [EA] | C |
|
Nat Genet | Gudbjartsson DF (2009) |
| Left ventricular end-diastolic volume | C |
|
Nat Genet | Tadros R (2021) |
| Systolic blood pressure [EA, initial] | C |
|
Hypertension | Wain LV (2017) |
| Systolic blood pressure | C |
|
Nat Genet | Levy D (2009) |
| Diastolic blood pressure [EA] | C |
|
Nat Genet | Kato N (2015) |
| Diastolic blood pressure [EA, initial] | C |
|
Hypertension | Wain LV (2017) |
| Diastolic blood pressure | C |
|
Nat Genet | Ehret GB (2016) |
| Type 1 diabetes | C |
|
Unknown journal | Crouch D (2021) |
| Celiac disease | C |
|
Unknown journal | UKB SAIGE (2018) |
| Medication use (thyroid preparations) | C |
|
Nat Commun | Wu Y (2019) |
| Haematocrit percentage | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Whole body fat-free mass | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Plateletcrit | C |
|
Cell | Vuckovic D (2020) |
| IgA levels [Recessive] | C |
|
Nat Genet | Jonsson S (2017) |
| White blood cell (leukocyte) count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Eosinophil counts | C |
|
Cell | Vuckovic D (2020) |
| Platelet count | C |
|
Cell | Chen MH (2020) |
| Whole body water mass | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Standing height | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Lymphocyte counts | C |
|
Cell | Vuckovic D (2020) |
| Eosinophil percentage of white cells | C |
|
Cell | Vuckovic D (2020) |
| Trunk fat-free mass | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Trunk predicted mass | C |
|
Unknown journal | UKB Neale v2 (2018) |
| C-C motif chemokine 3 levels | C |
|
Nat Metab | Folkersen L (2020) |
| Hemoglobin | C |
|
Cell | Vuckovic D (2020) |
| White blood cell count | C |
|
Cell | Chen MH (2020) |
| Eosinophill count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Hemoglobin concentration | C |
|
Cell | Astle WJ (2016) |
| Hematocrit | C |
|
Cell | Vuckovic D (2020) |
| Glaucoma (multi-trait analysis) | C |
|
Nat Genet | Craig JE (2020) |
| Hemoglobin levels | C |
|
Commun Biol | Oskarsson GR (2020) |
| Reticulocyte fraction of red cells | C |
|
Cell | Vuckovic D (2020) |
| Haemoglobin concentration | C |
|
Unknown journal | UKB Neale v2 (2018) |
| High light scatter reticulocyte percentage of red cells | C |
|
Cell | Vuckovic D (2020) |
| Medication use (calcium channel blockers) | C |
|
Nat Commun | Wu Y (2019) |
| Red blood cell traits [EA, Hgb] | C |
|
Nature | van der Harst P (2012) |
| Lymphocyte count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Red blood cell count | C |
|
Cell | Astle WJ (2016) |
| Monocyte count | C |
|
Cell | Chen MH (2020) |
| Neutrophill count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Myeloid white cell count | C |
|
Cell | Astle WJ (2016) |
| Total cholesterol levels [EA] | C |
|
Nat Genet | Hoffmann TJ (2018) |
| Granulocyte count | C |
|
Cell | Astle WJ (2016) |
| Low density lipoprotein cholesterol levels [EA] | C |
|
Nat Genet | Hoffmann TJ (2018) |
| Total cholesterol levels | C |
|
Nat Genet | Hoffmann TJ (2018) |
| Sum neutrophil eosinophil counts | C |
|
Cell | Astle WJ (2016) |
| Offspring birth weight | C |
|
Hum Mol Genet | Beaumont RN (2018) |
| Immature fraction of reticulocytes | C |
|
Cell | Vuckovic D (2020) |
| Cholesterol, total | C |
|
Nat Genet | Willer CJ (2013) |
| Low density lipoprotein cholesterol levels | C |
|
Nat Genet | Hoffmann TJ (2018) |
| Tumor necrosis factor levels | C |
|
EBioMedicine | Yuan S (2020) |
| Reticulocyte percentage | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Basophil count | C |
|
Cell | Chen MH (2020) |
| HDL cholesterol levels | C |
|
PLoS Med | Richardson TG (2020) |
| Sum basophil neutrophil counts | C |
|
Cell | Astle WJ (2016) |
| High density lipoprotein cholesterol levels [EA] | C |
|
Nat Genet | Hoffmann TJ (2018) |
| High density lipoprotein cholesterol levels | C |
|
Nat Genet | Hoffmann TJ (2018) |
| Birth weight | C |
|
Nat Genet | Warrington NM (2019) |
| Leg fat-free mass (right) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Beta-2 microglubulin plasma levels | C |
|
Hum Genet | Tin A (2013) |
| Leg predicted mass (right) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Leg predicted mass (left) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Appendicular lean mass | C |
|
Commun Biol | Pei YF (2020) |
| Apolipoprotein A1 levels | C |
|
PLoS Med | Richardson TG (2020) |
| Parental longevity (father's attained age) | C |
|
Aging (Albany NY) | Pilling LC (2017) |
| Blood metabolite levels [kynurenine] | C |
|
Nat Genet | Shin SY (2014) |
| Red blood cell (erythrocyte) count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Basophill count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Body mass index | C |
|
Nat Genet | Turcot V (2017) |
| Glomerular filtration rate (cystatin C) | C |
|
Nat Commun | Pattaro C (2016) |
| Arm fat-free mass (left) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| High light scatter reticulocyte percentage | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Arm predicted mass (left) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Arm fat-free mass (right) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Arm predicted mass (right) | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Urate levels | C |
|
Elife | Sinnott-Armstrong N (2021) |
| Platelet crit | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Liver enzyme levels (alanine transaminase) | C |
|
Nat Commun | Pazoki R (2021) |
| Immature reticulocyte fraction | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Reticulocyte count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| High light scatter reticulocyte count | C |
|
Unknown journal | UKB Neale v2 (2018) |
| "Hypothyroidism, drug reimbursement" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 1 diabetes, wide definition" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 1 diabetes, wide definition, subgroup 1" | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Acute upper respiratory infections | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Alanine aminotransferase levels | C |
|
Nat Commun | Ward LD (2021) |
| Aspartate aminotransferase levels | C |
|
Nat Commun | Ward LD (2021) |
| Autoimmune diseases | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Autoimmune thyroid disease | C |
|
Nature | Saevarsdottir S (2020) |
| Blood pressure medication | medication for cholesterol, blood pressure or diabetes | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Cardiovascular disease | C |
|
Am J Hum Genet | Kichaev G (2018) |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) [subset analysis] | C |
|
Nat Genet | Ellinghaus D (2016) |
| Colorectal cancer | C |
|
Nat Commun | Schumacher FR (2015) |
| Colorectal cancer [EA] | C |
|
J Natl Cancer Inst | Schmit SL (2018) |
| Colorectal or endometrial cancer [same direction] | C |
|
Sci Rep | Cheng TH (2015) |
| Coronary artery disease | C |
|
Nat Genet | Nikpay M (2015) |
| Crohn's disease [EA] | C |
|
Nat Genet | Liu JZ (2015) |
| Diastolic blood pressure (cigarette smoking interaction) | C |
|
Am J Hum Genet | Sung YJ (2018) |
| Endometrial cancer | C |
|
Nat Commun | O'Mara TA (2018) |
| Endometrial cancer (endometrioid histology) | C |
|
Nat Commun | O'Mara TA (2018) |
| Essential hypertension | C |
|
Unknown journal | UKB SAIGE (2018) |
| Fibrinogen levels | C |
|
PLoS One | de Vries PS (2017) |
| Height | C |
|
Am J Hum Genet | Kichaev G (2018) |
| High blood pressure | illnesses of siblings | C |
|
Unknown journal | UKB Neale v2 (2018) |
| High blood pressure | vascular/heart problems diagnosed by doctor | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Hypertension | C |
|
Unknown journal | UKB SAIGE (2018) |
| Hypothyroidism | C |
|
PLoS One | Eriksson N (2012) |
| Hypothyroidism nos | C |
|
Unknown journal | UKB SAIGE (2018) |
| Hypothyroidism/myxoedema | non-cancer illness code, self-reported | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Inflammatory bowel disease [EA] | C |
|
Nat Genet | Liu JZ (2015) |
| Intestinal malabsorption (non-celiac) | C |
|
Unknown journal | UKB SAIGE (2018) |
| Ischemic stroke | C |
|
Nat Genet | Malik R (2018) |
| Latent autoimmune diabetes vs. type 2 diabetes | C |
|
Diabetes Care | Cousminer DL (2018) |
| Levothyroxine sodium | treatment/medication code | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Multiple sclerosis | C |
|
Science | International Multiple Sclerosis Genetics Consortium (2019) |
| Neutrophil count | C |
|
Cell | Chen MH (2020) |
| None of the above | vascular/heart problems diagnosed by doctor | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Primary sclerosing cholangitis | C |
|
Nat Genet | Liu JZ (2013) |
| Stroke | C |
|
Nat Genet | Malik R (2018) |
| Systolic blood pressure (cigarette smoking interaction) | C |
|
Am J Hum Genet | Sung YJ (2018) |
| Thyroxine product | treatment/medication code | C |
|
Unknown journal | UKB Neale v2 (2018) |
| Tonsillectomy | C |
|
Nat Commun | Tian C (2017) |
| Type 1 diabetes with ophthalmic complications | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Type 1 diabetes with other specified/multiple/unspecified complications | C |
|
Unknown journal | FINNGEN_R5 (2021) |
| Type 1 diabetes without complications | C |
|
Unknown journal | FINNGEN_R5 (2021) |
Summary
In a recent (2008) study of non-HLA SNP associations of 1600+ celiac disease patients, this SNP was considered one of the most significant. The odds ratio for the minor allele was 1.19 (CI:1.10-1.30, p=1.33x10e-7). rs653178, another SNP in strong linkage disequilibrium (r2>0.99) with rs3184504, was also associated with celiac disease.[type-1 diabetes
heart attack
SNP Risk Version Effect
- rs646776 T 1.19
- rs17465637 C 1.14
- rs1746048 C 1.17
- rs6725887 C 1.17
- rs11206510 T 1.15
- rs3184504 T 1.13
- rs2306374 C 1.15
- rs3782886 C 1.44
23andMe blog blood pressure
[PMID 25009551] The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study
[PMID 23844121] Thrombotic Antiphospholipid Syndrome Shows Strong Haplotypic Association with SH2B3-ATXN2 Locus
[PMID 23328882] Meta-analyses of four eosinophil related gene variants in coronary heart disease.
[PMID 22525200] Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.
[PMID 22493691] Novel associations for hypothyroidism include known autoimmune risk Loci.
[PMID 22328738] Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
[PMID 22087237] Improving the estimation of celiac disease sibling risk by non-HLA genes
[PMID 21253569] Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?
[PMID 21193429] Determinants of platelet count in humans.
[PMID 20560212] Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection
[PMID 20546165] The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients.
[PMID 20508602] The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis
[PMID 20045101] Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 19951419] Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis
[PMID 19693089] Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort
[PMID 19913121] Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
[PMID 19862010] Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
[PMID 19860791] Genetic evidence for a role of IL33 in nasal polyposis.
[PMID 19307593] Signals of recent positive selection in a worldwide sample of human populations.
[PMID 19168599] Type 1 diabetes in the BB rat: a polygenic disease.
[PMID 19073967] Shared and distinct genetic variants in type 1 diabetes and celiac disease.
[PMID 18987646] The expanding genetic overlap between multiple sclerosis and type I diabetes.
[PMID 18978792] Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
[PMID 18713140] Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.
[PMID 18556337] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
[PMID 18252225] On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.
[PMID 26535636] Association between IL2/IL21 and SH2B3 polymorphisms and risk of celiac disease: a meta-analysis
[PMID 26553438] Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer
More Information
T = increased risk for celiac disease.
In a study of non-HLA SNP associations of 1600 celiac disease patients, this SNP was considered one of the most significant (OR =1.19, p=1.33x10e-7) [R].
Individuals with the T allele should be cautious about gluten.
Population Alleles Frequency
| ethhicity | frequency |
|---|---|
| African/African-American | 0.9174 |
| Latino/Admixed American | 0.7459 |
| Ashkenazi Jewish | 0.3507 |
| East Asian | 0.9994 |
| European | 0.5226 |
| Other (population not assigned) | 0.6241 |
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