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(High) Cholesterol
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Varicose Veins
H. pylori
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Hair Loss (Male-Pattern Baldness)
Riboflavin
Urticaria
Rosacea
Carpal Tunnel Syndrome
Sinus Congestion
Cavities
Artery Hardening
Vertigo
Vitiligo
Myopia
Indigestion
Excessive Sweating
Testosterone – Males
Yeast infection (Candida)
Endometriosis
Tobacco addiction
Alcohol addiction
Uterine fibroids
Length of menstrual cycle
UTI
OCD
Kidney Stones
Vitamin B12
Vitamin C
Vitamin D
Folate
Iron
Eating Disorders
Bone Health
Hypothyroidism
Hyperthyroidism
Sugar Cravings
Hearing/difficulty problem /Hearing loss
Painful Periods
Palpitations
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Hypotension
Bladder Control
Constipation
Appendicitis
Low Blood Sugar
Irregular Periods
Metabolic rate
Visceral fat
Lung Health
Anemia
Calcium
Cognition
Cognitive Decline
Seasonal Low Mood
Vitamin K
Phosphate
HRV
Cluster headaches
Knee Pain
Hip Pain
Selenium
Low back injury
Dyslexia
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Histamine Intolerance
Carnitine
Pesticide Sensitivity
Organophosphate Sensitivity
Cadmium
Lead
Melatonin
FSH
T4
T3
High PTH
Potassium
Coenzyme Q10 (CoQ10)
Chromium
Oxalate Sensitivity
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Facial Wrinkles
Age Spots
Ligament Rupture (ACL Injury)
Tendon Injury (Tendinopathy)
Omega 6
Omega 6:Omega 3 Ratio
Arachidonic Acid
Oleic Acid
Alpha-Linolenic Acid
EPA
GLA
Linoleic Acid
DHA
Insulin Resistance
Sperm Motility
Homocysteine
C difficile
Pneumonia
EBV Infection
Gastrointestinal Infection
Chronic Bronchitis
Copper
Skin Elasticity
Skin Hydration
Egg allergy
ApoB
GGT
TIBC
Bioavailable Testosterone (Male)
MPV
Chloride
Free T4
Processing Speed
Short-term memory
TMAO
Air pollution sensitivity
Heart Rate
VO2 Max
Flu
Hair graying
Caffeine-Related Sleep Problems
Groin Hernia
Stretch marks
Droopy Eyelids
Strep infection
Dry eyes
Carbohydrate Consumption
Peanut allergy
Heart rate recovery
Muscle recovery
Jaw Disorders
HPV Infection
Acute Bronchitis
Chlamydia
Genital Herpes
Pancreas inflammation
Executive Function
Pyroglutamic acid
Raynaud’s
Liver Scarring
Dandruff
Bioavailable Testosterone (Female)
Shrimp allergy
Haptoglobin
Milk allergy
Beta-Alanine
Taurine
LDL Particle Size
Diarrhea
Snoring
Uric acid
Phenylalanine
Leucine
Glutamine
Valine
Glycine
Alanine
Lysine
Arginine
Histidine
Tyrosine
Cortisol
DHEAS
Insulin
Prolactin
TSH
Lactate
Ketone Bodies
IL-17A (Th17 Dominance)
Creatine Kinase
Neutrophils
Basophils
Eosinophils
Ferritin
ALT
AST
MCV
Hematocrit
RDW
SHBG
Total Protein
Albumin
MCH
Sodium
MCHC
Alkaline Phosphatase
Monocytes
Ghrelin
IL10 (Th2)
IL-6 (Th2 and Th17)
Iodine
Chili Pepper sensitivity
COMT
DRD2 (Dopamine)
Lectin Sensitivity
Thiamine
Biotin
Mold Sensitivity (Foodborne)
Chronic Lyme
BDNF
Glyphosate sensitivity
BPA Sensitivity
Pregnenolone
Luteinizing Hormone (LH)
Growth Hormone
IgA
Molybdenum
Sensitivity to Dairy (IgG Casein)
Telomere Length
Serotonin (5HIAA)
Non-Celiac Gluten Sensitivity (IgG Gliadin)
Manganese
Klotho
Mold Sensitivity (Airborne)
Amylase
Lipase
Low Sperm Count
Tryptophan
Methionine
Glutamate
Proline
Blood Calcium
Hypertriglyceridemia
HDL Cholesterol
HbA1c
Hemoglobin
Total Cholesterol
LDL Cholesterol
IGF1
Fasting Glucose
Bilirubin (total)
White blood cell count
Red blood cell count
Platelets
eGFR
Creatinine
Estradiol
Neuroticism
Sleep Quality
Lactose Intolerance
Saturated fat
Optimal diet
Unsaturated fat
Achilles tendon injury
Deep sleep
Fat
Response to Stress
Leadership
Ankle injury
Creativity
Hoarding
Protein
Optimal Exercise
Knee Injury
Rotator cuff injury
Extraversion
Risk-Taking
Happiness
Daytime Sleepiness
Morningness
Time spent watching TV
Disliking cilantro
Alcohol Sensitivity
Response to Caffeine
Snacking
Weight Regain
Sleep movement
Wearing glasses or contacts
Educational Attainment
Bitter Taste Sensitivity
Agreeableness
Aggression
Conscientiousness
Openness to experience
Physical activity
Caffeine-Related Anxiety
Naps
SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more
rs2476601
Chromosome
: 1 , Position: 113834946
Most conditions are affected by anywhere from hundreds to millions of
genetic variants (SNPs). A single SNP usually has a minor contribution to
a person’s overall genetic risk for a certain condition. That is why you
shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to
determine polygenic risk scores (PRSs), which are the basis of most health
reports.
Reference Allele: A
Alternative Alleles:
G
Traits
| Trait | Variant | Impact | PMID | Author (year) |
|---|---|---|---|---|
| Medication use (thyroid preparations) | G |
|
Nat Commun | Wu Y (2019) |
| Lymphocyte percentage | G |
|
Unknown journal | UKB Neale v2 (2018) |
| IgM levels | G |
|
Nat Genet | Jonsson S (2017) |
| Medication use (drugs used in diabetes) | G |
|
Nat Commun | Wu Y (2019) |
| White blood cell (leukocyte) count | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Lymphocyte counts | G |
|
Cell | Astle WJ (2016) |
| White blood cell count | G |
|
Cell | Chen MH (2020) |
| Sum basophil neutrophil counts | G |
|
Cell | Astle WJ (2016) |
| Myeloid white cell count | G |
|
Cell | Astle WJ (2016) |
| Sum neutrophil eosinophil counts | G |
|
Cell | Astle WJ (2016) |
| Granulocyte count | G |
|
Cell | Astle WJ (2016) |
| Neutrophill count | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Neutrophil count | G |
|
Cell | Chen MH (2020) |
| Lymphocyte count | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Serum alkaline phosphatase levels | G |
|
Nat Genet | Sinnott-Armstrong N (2021) |
| Number of self-reported non-cancer illnesses | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Monocyte count | G |
|
Cell | Chen MH (2020) |
| "Diabetes, insuline treatment (Kela reimbursement)" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Diabetes, insuline treatment (Kela reimbursement)" (more controls excluded) | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Diabetes, several complications" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Diabetes, varying definitions" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Endocrine, nutritional and metabolic diseases" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Hypothyroidism, other/unspecified" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Hypothyroidism, drug reimbursement" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Hypothyroidism, levothyroxin purchases" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Hypothyroidism, strict autoimmune" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Hypothyroidism, strict autoimmune, 3 medication purchases required" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Other (seronegative) rheumatoid arthritis, wide" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Other diabetes, wide definition" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Seropositive rheumatoid arthritis, wide" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 1 diabetes, strict (exclude DM2)" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 1 diabetes, strict definition" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 1 diabetes, wide definition" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| "Type 1 diabetes, wide definition, subgroup 1" | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Addison's disease | G |
|
Nat Commun | Eriksson D (2021) |
| Adult-onset Still disease | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Autoimmune diseases | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Autoimmune hyperthyroidism | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Autoimmune thyroid disease | G |
|
Nature | Saevarsdottir S (2020) |
| Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) | G |
|
Hum Mol Genet | Cooper JD (2012) |
| Autoimmune thyroiditis | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Autoimmune traits | G |
|
Am J Hum Genet | Kichaev G (2018) |
| Autoimmune traits (pleiotropy) | G |
|
Genome Med | Marquez A (2018) |
| Background diabetic retinopathy | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Basal cell carcinoma | G |
|
Genome Med | Adolphe C (2021) |
| Biological medication for rheuma | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) [subset analysis] | G |
|
Nat Genet | Ellinghaus D (2016) |
| Crohn's disease | G |
|
Nat Genet | Franke A (2010) |
| Crohn's disease [EA] | G |
|
Nat Genet | Liu JZ (2015) |
| Crohn's disease vs rheumatoid arthritis (ordinary least squares (OLS)) | G |
|
Nat Genet | Peyrot WJ (2021) |
| Crohn's disease vs ulcerative colitis (ordinary least squares (OLS)) | G |
|
Nat Genet | Peyrot WJ (2021) |
| Diabetes diagnosed by doctor | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Diabetes mellitus | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Diabetes | non-cancer illness code, self-reported | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Diabetes-related co-morbidities/complications (more controls excluded) | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Diabethic neuropathy | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Diabetic background retinopathy | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Diabetic hypoglycemia | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Diabetic neuropathy | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Diabetic retinopathy | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Diabetic retinopathy (more controls excluded) | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Disorders of the thyroid gland | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Finngen Rheumatological endpoints | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Graves' disease | G |
|
Hum Mol Genet | Cooper JD (2012) |
| Hashimoto thyroiditis | G |
|
Hum Mol Genet | Cooper JD (2012) |
| Hyperthyroidism/thyrotoxicosis | non-cancer illness code, self-reported | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Hypothyroidism | G |
|
Nat Genet | Pickrell JK (2016) |
| Hypothyroidism (congenital or acquired) | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Hypothyroidism and >3 levothyroxin purchases | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Hypothyroidism nos | G |
|
Unknown journal | UKB SAIGE (2018) |
| Hypothyroidism/myxoedema | non-cancer illness code, self-reported | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Idiopathic inflammatory myopathy | G |
|
Ann Rheum Dis | Rothwell S (2015) |
| Insulin product | treatment/medication code | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Insulin | medication for cholesterol, blood pressure or diabetes | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Insulin | medication for cholesterol, blood pressure, diabetes, or take exogenous hormones | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Interstitial lung disease endpoints | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| KELA_REIMBURSEMENT_202 | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Latent autoimmune diabetes vs. type 2 diabetes | G |
|
Diabetes Care | Cousminer DL (2018) |
| Levothyroxine sodium | treatment/medication code | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Long-standing illness, disability or infirmity | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Myasthenia gravis | G |
|
Ann Neurol | Gregersen PK (2012) |
| Nutritional anaemias | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Other diabetic retinopathy | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Other retinal disorders | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Other serious medical condition/disability diagnosed by doctor | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Other/unspecified rheumatoid arthritis | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Other/unspecified seropositiverheumatoid arthritis | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Pernicious anemia | G |
|
Unknown journal | UKB SAIGE (2018) |
| Polyarthropathies | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Polymyositis | G |
|
Ann Rheum Dis | Rothwell S (2015) |
| Proliferative diabetic retinopathy | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Rheumatoid arthritis | G |
|
J Adv Res | Saad MN (2019) |
| Rheumatoid arthritis (ACPA-positive) | G |
|
Nat Genet | Eyre S (2012) |
| Rheumatoid arthritis [ACPA-positive RA vs controls] | G |
|
Ann Rheum Dis | Padyukov L (2010) |
| Rheumatoid arthritis [EA] | G |
|
Nature | Okada Y (2013) |
| Rheumatoid arthritis and other inflammatory polyarthropathies | G |
|
Unknown journal | UKB SAIGE (2018) |
| Second line medication for Crohns disease | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Seronegative rheumatoid arthritis | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Seropositive rheumatoid arthritis | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Systemic lupus erythematosus | G |
|
Nat Genet | Gateva V (2009) |
| Systemic lupus erythematosus [EA] | G |
|
Nat Genet | Morris DL (2016) |
| Systemic lupus erythematosus or rheumatoid arthritis [same effect] | G |
|
Ann Rheum Dis | Marquez A (2016) |
| Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) | G |
|
Ann Rheum Dis | Acosta-Herrera M (2018) |
| Taking other prescription medications | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Thyrotoxicosis with diffuse goitre | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Thyroxine product | treatment/medication code | G |
|
Unknown journal | UKB Neale v2 (2018) |
| Type 1 diabetes | G |
|
Nat Genet | Todd JA (2007) |
| Type 1 diabetes and autoimmune thyroid diseases | G |
|
J Autoimmun | Tomer Y (2015) |
| Type 1 diabetes with coma | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Type 1 diabetes with ketoacidosis | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Type 1 diabetes with ophthalmic complications | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Type 1 diabetes with other specified/multiple/unspecified complications | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Type 1 diabetes with renal complications | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Type 1 diabetes without complications | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Unspecified diabetic retinopathy | G |
|
Unknown journal | FINNGEN_R5 (2021) |
| Vitiligo | G |
|
Nat Genet | Jin Y (2016) |
Summary
AA or AG=Rheumatoid arthritis, autoimmune conditions, less interferon type 1…
More Information
The A (minor) allele is associated with:
- Rheumatoid arthritis, autoimmune conditions, less interferon type 1 (AA or AG).
Population Alleles Frequency
| ethhicity | frequency |
|---|---|
| African/African-American | 0.9832 |
| Latino/Admixed American | 0.9682 |
| Ashkenazi Jewish | 0.9448 |
| East Asian | 1 |
| European | 0.8863 |
| Other (population not assigned) | 0.9033 |
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