rs2297518

Chromosome : 17 , Position: 27769571

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: G

Alternative Alleles: A

Associated Genes

NOS2

LGALS9

LYRM9

NLK

KSR1

WSB1

Summary

[PMID 20565800] Gastric cancer is associated with NOS2 -954G/C polymorphism and environmental factors in a Brazilian population

[PMID 20581851] Exploring epistatic relationships of NO biosynthesis pathway genes in susceptibility to CHD

[PMID 21716319] Maternal iNOS genetic polymorphisms and hypertensive disorders of pregnancy

[PMID 21963893] Polymorphisms of genes in nitric oxide-forming pathway associated with ischemic stroke in Chinese Han population

[PMID 22234503] Inducible nitric oxide synthase haplotype associated with migraine and aura

[PMID 16543247] Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma.

[PMID 16642433] Polymorphism in maternal LRP8 gene is associated with fetal growth.

[PMID 17355643] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 17955236] Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility.

[PMID 18663495] Nitric oxide synthase genes and their interactions with environmental factors in Parkinson’s disease.

[PMID 18667089] A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis.

[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 19168583] Nitric oxide synthase gene polymorphisms and prostate cancer risk.

[PMID 19309520] Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease.

[PMID 20416077] Identification of type 2 diabetes-associated combination of SNPs using support vector machine.

[PMID 20562898] Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia.

[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 21385363] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.

[PMID 21481004] Association between recurrent aphthous stomatitis and inheritance of a single-nucleotide polymorphism of the NOS2 gene encoding inducible nitric oxide synthase.

[PMID 21612325] Ser608Leu polymorphisms in the nitric oxide synthase-2 gene may influence urinary bladder cancer pathogenesis.

[PMID 23192595] A non-synonymous SNP in the NOS2 associated with septic shock in patients with sepsis in Chinese populations

[PMID 23572278] Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans

[PMID 24114042] Nitric Oxide Synthase Gene Polymorphisms in Functional Dyspepsia

[PMID 24430113] Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease

[PMID 22865486] Interaction among nitric oxide (NO)-related genes in migraine susceptibility.

[PMID 24746566] Genetic variants in inducible nitric oxide synthase gene are associated with the risk of radiation-induced lung injury in lung cancer patients receiving definitive thoracic radiation

[PMID 26579803] Functional Inducible Nitric Oxide Synthase Gene Variants Associate With Hypertension: A Case-Control Study in a Finnish Population-The TAMRISK Study

More Information

Mechanism:

Increased production of nitric oxide (A) [R]
Decreased production of nitric oxide (G) [R]

The Minor "A" allele is associated with:

Increased risk of hypertension in the Finnish population [R]

The Major "G" allele is associated with:

Decreased risk of hypertension in the Finnish population [R]

This SNP is associated with (unknown which alleles):

Increased risk for coronary heart disease [R]
Increase risk for rheumatoid arthritis [R]
Increased oxidative stress [R]

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.1195
Latino/Admixed American	0.1478
Ashkenazi Jewish	0.2483
East Asian	0.1686
European	0.1866
Other (population not assigned)	0.1845

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

Unlock Personalized Results And So Much More!

Shipping Worldwide

30-Days Money-Back Guarantee*

HSA/FSA Eligible

Essential Bundle

SelfDecode DNA Kit

24/7 AI Health Coach
1250+ Comprehensive DNA Health Reports
Personalized Diet, Supplement, & Lifestyle Recommendations
Lifestyle Risk Assessments
Unlimited access to Labs Analyzer

$418

$376

Men's Health Month 10% Off

Essential

Bundle

Everything in essential
SelfDecode DNA Kit
Methylation Pathway
+130 Medical Reports
25+ Longevity Screener Risk Assessments

Odds ratios to evaluate your risk for 25+ medical conditions
10-year risk scores to prioritize health conditions
Lifetime risk scores to plan for long-term health

$667

$566

Men's Health Month 15% Off

Men's Health Month 30% Off

Ultimate Bundle

Everything in essential+
SelfDecode DNA Kit
Medication Check (PGx testing) for 50+ medications
40+ Family Planning (Carrier Status) Reports
Ancestry Percentages
Mitochondrial Ancestry

$894

$625

* SelfDecode DNA kits are non-refundable. If you choose to cancel your plan within 30 days you will not be refunded the cost of the kit.

We will never share your data

We follow HIPAA and GDPR policies

We have World-Class Encryption & Security

People Love Us

Rated 4.7/5 from 750+ reviews

People Trust Us

200,000+ users, 2,000+ doctors & 80+ businesses

SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.

Policies

About

Support
Our Team
Affiliate Program
Privacy
Media