SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more

rs2073618

Chromosome : 8 , Position: 118951813

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: G

Alternative Alleles: C

Associated Genes

TNFRSF11B

COLEC10

SAMD12

MAL2

CCN3

Summary

[PMID 20231205] Genetic Variations in Genes Encoding RANK, RANKL, and OPG in Rheumatoid Arthritis: A Case-Control Study

[PMID 22079369] TNFRSF11B gene haplotype and its association with bone mineral density variations in postmenopausal Mexican-Mestizo women

[PMID 21964949] Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men

[PMID 16583245] Genetic susceptibility to hip arthroplasty failure–association with the RANK/OPG pathway.

[PMID 19458885] Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians.

[PMID 20205168] Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men.

[PMID 21396799] Genetic polymorphisms and other risk factors associated with bisphosphonate induced osteonecrosis of the jaw.

[PMID 21411255] TNFRSF11B gene polymorphisms 1181G > C and 245T > G as well as haplotype CT influence bone mineral density in postmenopausal women.

[PMID 23369128] Genetic polymorphism of the OPG gene associated with breast cancer

[PMID 24130145] Polymorphism of LRP5, but not of TNFRSF11B, is associated with a decrease in bone mineral density in postmenopausal maya-mestizo women

[PMID 24228244] SNP rs2073618 of the Osteoprotegerin Gene Is Associated with Diabetic Retinopathy in Slovenian Patients with Type 2 Diabetes

[PMID 24283361] Association Between Seven Common OPG Genetic Polymorphisms and Osteoporosis Risk: A Meta-Analysis

[PMID 23299915] Osteoprotegerin gene rs2073617 and rs3134069 polymorphisms in type 2 diabetes patients and sexspecific rs2073618 polymorphism as a risk factor for diabetic foot.

[PMID 23531404] Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.

[PMID 25032118] Exclusion of TNFRSF11B as Candidate Gene for Otosclerosis in Campania Population

[PMID 25323794] TNFRSF11B gene polymorphisms, bone mineral density, and fractures in Slovak postmenopausal women

[PMID 25679449] A Variant in the Osteoprotegerin Gene Is Associated with Coronary Atherosclerosis in Patients with Rheumatoid Arthritis: Results from a Candidate Gene Study

[PMID 26218592] RANKL and OPG Polymorphisms Are Associated with Aromatase Inhibitor-Related Musculoskeletal Adverse Events in Chinese Han Breast Cancer Patients

[PMID 26451891] RANK rs1805034 T>C Polymorphism Is Associated with Susceptibility to Gastric Cardia Adenocarcinoma in a Chinese Population

[PMID 26579581] Genetic and environmental predictors of chronic kidney disease in patients with type 2 diabetes and diabetic foot ulcer: a pilot study

More Information

The minor allele ''G'' was associated with higher levels of both propeptide of type I procollagen (PINP) (p = .004) and cross-linked telopeptide of type I collagen (CTX-I) (p = 4.74 x 10(-4)), and lower lumbar spine bone mineral density (BMD) (a) (p = .026) [R].

In osteoporotic postmenopausal women, lumbar spine bone mineral density (BMD) was associated with G > C polymorphism (p =0.006) [R].

Carriers of the CC genotype had a 2.2 higher risk for diabetic retinopathy (DR) than those with either the CG genotype or the GG genotype. The odds ratio (OR) for individuals with CC genotype compared with carriers of CG/GG was 2.54 (P = 0.01) [R].

Individuals with the ''C'' allele had a decreased risk of osteoporosis, especially in Asian and postmenopausal woman subgroups [R].

The ''C'' allele was a risk factor for diabetic foot in patients with diabetes [CC] vs. [CG + GG] (odds ratio [OR], 1.72; P = 0.035), and in men in the following allelic variants: CC vs. GG (OR, 3.16; P = 0.011), CC vs. CG (OR, 3.33; P = 0.002), and [CC] vs. [CG + GG] (OR, 3.28; P = 0.002) [R].

CC genotype in breast cancer patients were more likely to have a lower OPG level and a higher RANKL/OPG ratio than carriers of the GG genotype (all p < 0.05) [R].

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.8663
Latino/Admixed American	0.4752
Ashkenazi Jewish	0.5345
East Asian	0.7497
European	0.4635
Other (population not assigned)	0.5379

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

Unlock Personalized Results And So Much More!

Shipping Worldwide

30-Days Money-Back Guarantee*

US & EU Based Labs & Shipping

Essential Bundle

SelfDecode DNA Kit Included

24/7 AI Health Coach
1500+ Comprehensive DNA Health Reports
Personalized Diet, Supplement, & Lifestyle Recommendations
Lifestyle Risk Assessments
Unlimited access to Labs Analyzer

$418

HSA & FSA Eligible

Black Friday Deal

🚨 Get 3 for $590 (53% Off!)

Essential

Bundle

SelfDecode DNA Kit Included

Everything in essential
Detox Pathways
Methylation Pathway
Histamine Pathway
Dopamine & Norepinephrine Pathway Report
+130 Medical Reports
25+ Longevity Screener Risk Assessments

$690

HSA & FSA Eligible

Black Friday Deal

🚨 Get 3 for $890 (57% Off!)

HSA & FSA Eligible

Ultimate Bundle

SelfDecode DNA Kit Included

Everything in essential+
Medication Check (PGx testing) for 50+ medications
DNAmind PGx Report
40+ Family Planning (Carrier Status) Reports
Ancestry Composition
Deep Ancestry (Mitochondrial)

Limited Time Offer 25% Off

$927

$695

Black Friday Deal

🚨 Get 3 for $927 (67% Off!)

Already Have Your DNA Results? Upload Your DNA File

* SelfDecode DNA kits are non-refundable. If you choose to cancel your plan within 30 days you will not be refunded the cost of the kit.

We will never share your data

We follow HIPAA and GDPR policies

We have World-Class Encryption & Security

People Love Us

Rated 4.7/5 from 750+ reviews

People Trust Us

200,000+ users, 2,000+ doctors & 100+ businesses

SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.

Policies

About

Support
Our Team
Affiliate Program
Privacy
Media

Navigation

Family Plan 👪
Gift SelfDecode 🎁
Analyze Bloodwork 🧪
Report Shop 🛒
Register My Kit
Careers
About
Login

rs2073618

Associated Genes

Summary

More Information

Population Alleles Frequency

Frequently Asked Questions

Unlock Personalized Results And So Much More!

Essential Bundle

Essential

Bundle

Ultimate Bundle

Limited Time Offer 25% Off

Policies

About

Navigation

Health reports