rs1800947

Chromosome : 1 , Position: 159713648

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: C

Alternative Alleles: A, T, G

Associated Genes

CRP

DUSP23

FCRL6

OR10J1

SLAMF8

APCS

VSIG8

CFAP45

OR10J5

TAGLN2

IGSF9

SLAMF9

FCER1A

PIGM

KCNJ10

KCNJ9

ACKR1

ATP1A2

IGSF8

ATP1A4

CADM3

CASQ1

PEA15

Traits

Trait	Variant	PMID	Author (year)
"Pneumonia, organism unsepcified"	G	Unknown journal	FINNGEN_R5 (2021)
All pneumoniae	G	Unknown journal	FINNGEN_R5 (2021)
Influenza and pneumonia	G	Unknown journal	FINNGEN_R5 (2021)
Pneumonia (excl. viral and due to other infectious organisms not elsewhere classified)	G	Unknown journal	FINNGEN_R5 (2021)

Summary

Although somewhat lacking in statistical power, several reports have linked rs1800947, a synonymous mutation known as CRP2 in the C-reactive protein CRP to the autoimmune disorder SLE, systemic lupus erythematosus. The risk allele in dbSNP orientation is (C). [PMID 14645206, PMID 15897982, PMID 18216863]

news C linked to lower CRP levels

[PMID 19040303] C-reactive protein gene polymorphisms in biopsy-proven giant cell arteritis from Northwestern Spain

[PMID 19426506] C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery

[PMID 19436291] C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk

[PMID 19101671] Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity

[PMID 19692124] Complement Factor H Y402H and C-Reactive Protein Polymorphism and Photodynamic Therapy Response in Age-Related Macular Degeneration

[PMID 19821022] Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples

[PMID 20552244] Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia

[PMID 20733302] Genetic Variants in the C-Reactive Protein Gene Are Associated with Microangiopathic Ischemic Stroke

[PMID 20333461] Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population

[PMID 20949557] Genetic variation in C-reactive protein (CRP) in relation to colon and rectal cancer risk and survival

[PMID 21293934] Association of C-reactive Protein Gene Polymorphisms and Colorectal Cancer

[PMID 21413847] Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey

[PMID 21080913] The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study

[PMID 16519819] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16550411] Allelic spectrum of the natural variation in CRP.

[PMID 16723442] A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

[PMID 16733231] Association study between C-reactive protein genes and ischemic stroke in Japanese subjects.

[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16832152] Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

[PMID 17355643] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

[PMID 17888441] Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.

[PMID 17900590] C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

[PMID 17956875] DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study.

[PMID 18000615] Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study.

[PMID 18167554] C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

[PMID 18394581] Bayesian meta-analysis of genetic association studies with different sets of markers.

[PMID 18426996] Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.

[PMID 18439548] Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women’s Genome Health Study.

[PMID 18499652] C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease: the LURIC study.

[PMID 18500540] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

[PMID 18704199] Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

[PMID 18793001] Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

[PMID 18974842] Gender differences in genetic risk profiles for cardiovascular disease.

[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

[PMID 19075099] Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity.

[PMID 19076828] Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

[PMID 19095725] Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women’s Health Initiative Observational Cohort.

[PMID 19267250] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

[PMID 19272152] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

[PMID 19410251] Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

[PMID 19762396] Factors associated with arterial vascular events in PROFILE: a Multiethnic Lupus Cohort.

[PMID 19796676] Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein.

[PMID 19906786] Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.

[PMID 20616999] Usefulness of Mendelian randomization in observational epidemiology.

[PMID 21034294] C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

[PMID 21325005] Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

[PMID 21647738] Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

[PMID 21773944] Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.

[PMID 21790705] The polymorphisms of C-reactive protein gene modify the association between central obesity and lung function in taiwan asthmatics.

[PMID 21979869] C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

[PMID 23254959] Serum C-reactive protein and risk of lung cancer: a case-control study

[PMID 23397258] Association study of CRP gene in systemic sclerosis in European Caucasian population.

[PMID 24844401] Genetic variation across C-reactive protein and risk of prostate cancer

[PMID 24862635] Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E)

[PMID 24894103] Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis

[PMID 24761881] Genotype CC of rs1800947 in the C-reactive protein gene may increase susceptibility to colorectal cancer: a meta-analysis

[PMID 25043606] Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

[PMID 26004291] C-reactive protein gene polymorphisms and gene-environment interactions in ischaemic stroke

[PMID 26550110] The role of gene variants of the inflammatory markers CRP and TNF-Œ in cardiovascular heart disease: systematic review and meta-analysis

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