rs1176744

Chromosome : 11 , Position: 113932306

Most conditions are affected by anywhere from hundreds to millions of genetic variants (SNPs). A single SNP usually has a minor contribution to a person’s overall genetic risk for a certain condition. That is why you shouldn't consider or act on a SNP in isolation. Instead, we use SNPs to determine polygenic risk scores (PRSs), which are the basis of most health reports.

Reference Allele: A

Alternative Alleles: C

Associated Genes

HTR3B

NNMT

HTR3A

USP28

CLDN25

TMPRSS5

ZBTB16

ZW10

C11ORF71

DRD2

RBM7

Summary

[PMID 19741568] Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders

[PMID 20838391] Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence

[PMID 21570824] Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids

[PMID 17708757] Genome bioinformatic analysis of nonsynonymous SNPs.

[PMID 18330705] Physiogenomic analysis of localized FMRI brain activity in schizophrenia.

[PMID 19185213] HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power–an intermediate phenotype for alcoholism and co-morbid behaviors.

[PMID 21172166] Pharmacogenetics of antidepressant response.

[PMID 21184810] Are serotonin 3A and 3B receptor genes associated with suicidal behavior in schizophrenia subjects?

[PMID 23757001] Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence

[PMID 23290502] Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers

More Information

The Minor “C” allele is associated with:

Higher risk of depression [R].
Higher score on the catastrophizing pain scale, particularly the subscales of magnification and helplessness. This correlates with the risk of depression associated with this SNP [R].

This SNP is associated with (unknown alleles):

Higher risk of developing of anorexia nervosa [R].
Higher risk of Alcoholism [R].
Higher risk of an antisocial personality disorder along with alcoholism [R].
Higher risk of vomiting as a side effect of opioid drugs being used to treat cancer [R].
Higher risk of developing bipolar affective disorder [R].
Higher risk of Nicotine dependence [R].

Population Alleles Frequency

ethhicity	frequency
African/African-American	0.432
Latino/Admixed American	0.3432
Ashkenazi Jewish	0.3776
East Asian	0.1485
European	0.323
Other (population not assigned)	0.3186

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

Unlock Personalized Results And So Much More!

Shipping Worldwide

30-Days Money-Back Guarantee*

HSA/FSA Eligible

Essential Bundle

SelfDecode DNA Kit

24/7 AI Health Coach
1250+ Comprehensive DNA Health Reports
Personalized Diet, Supplement, & Lifestyle Recommendations
Lifestyle Risk Assessments
Unlimited access to Labs Analyzer

$418

$376

Men's Health Month 10% Off

Essential

Bundle

Everything in essential
SelfDecode DNA Kit
Methylation Pathway
+130 Medical Reports
25+ Longevity Screener Risk Assessments

Odds ratios to evaluate your risk for 25+ medical conditions
10-year risk scores to prioritize health conditions
Lifetime risk scores to plan for long-term health

$667

$566

Men's Health Month 15% Off

Men's Health Month 30% Off

Ultimate Bundle

Everything in essential+
SelfDecode DNA Kit
Medication Check (PGx testing) for 50+ medications
40+ Family Planning (Carrier Status) Reports
Ancestry Percentages
Mitochondrial Ancestry

$894

$625

* SelfDecode DNA kits are non-refundable. If you choose to cancel your plan within 30 days you will not be refunded the cost of the kit.

We will never share your data

We follow HIPAA and GDPR policies

We have World-Class Encryption & Security

People Love Us

Rated 4.7/5 from 750+ reviews

People Trust Us

200,000+ users, 2,000+ doctors & 80+ businesses

SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.

Policies

About

Support
Our Team
Affiliate Program
Privacy
Media