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IL21
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs747693305 | |||
| rs1006297904 | |||
| rs1382113628 | |||
| rs75392577 | |||
| rs150188995 | |||
| rs541143338 | |||
| rs777688890 | |||
| rs1270878378 | |||
| rs36116823 | |||
| rs4833837 | |||
| rs1014176553 | |||
| rs142473957 | |||
| rs17882114 | |||
| rs45576133 | |||
| rs778386448 | |||
| rs78956800 | |||
| rs908261619 | |||
| rs141766709 | |||
| rs189197916 | |||
| rs76369493 |
Find on This Page
Summary
IL21 codes for a protein with a wide range of pro-inflammatory and self-targeting functions. It plays a role in both the innate and adaptive immune responses. A variant of IL21 may play a role in alopecia areata by increasing levels of IL-21. [R].
Lifestyle, diet, and supplement modifications may counteract the effects of this variant by lowering IL-21 production, reducing pro-inflammatory cell activity, and/or promoting the activity of regulatory cells.
Protein names
Found in These Blog Articles
GHR Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
More Information
The IL21 gene codes for interleukin 21 (IL-21), an immune messenger (cytokine) with a wide range of pro-inflammatory and self-targeting (autoimmune) functions [R, R].
For example, IL-21 is involved in the development of inflammatory T cell subsets, such as Th17 cells [R, R, R].
Elevated levels of cytokines released from Th17 cells are often observed in autoimmune disorders, such as alopecia areata (spot baldness). In fact, higher Th17 cytokine levels have been linked to increased alopecia areata severity [R, R].
IL-21 also suppresses regulatory T cells (Tregs) that normally function to prevent autoimmunity, while stimulating cellular pathways in B cells that may promote the release of self-targeting antibodies (autoantibodies) [R].
Variants of IL21 have been associated with alopecia areata. These variants may increase the production of IL-21, leading to the development of pro-inflammatory and autoreactive immune cells [R, R, R, R].
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