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HNMT
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs11558538 | |||
| rs3100714 | |||
| rs10928646 | |||
| rs11687448 | |||
| rs12476519 | |||
| rs2015112 | |||
| rs3113236 | |||
| rs4954962 | |||
| rs1156057 | |||
| rs11680780 | |||
| rs12619760 | |||
| rs13408668 | |||
| rs1455148 | |||
| rs1840429 | |||
| rs1840430 | |||
| rs1980293 | |||
| rs2124207 | |||
| rs3100717 | |||
| rs6430767 | |||
| rs7559085 |
Summary
Protein names
Found in These Blog Articles
GHR Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
More Information
HNMT (histamine N-methyltransferase) encodes an enzyme that metabolizes histamine (R).
Polymorphisms of this gene are associated with:
From NCBI Gene: Asthma, susceptibility toMental retardation, autosomal recessive 51
From NCBI Gene: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008] From UniProt: Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
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