APOC3

SNP Table

variant	genotype	frequency	risk allele
rs138326449
rs147210663
rs201803883
rs2542052
rs5128
rs12721084
rs188386444
rs192830070
rs1458624017
rs111399027
rs112198691
rs113661446
rs12691374
rs1401137608
rs182351794
rs4520
rs5073
rs145925222
rs2127906
rs111423948

24806 associated SNPs in total

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Summary Blog Articles GHR Function Frequently Asked Questions

Summary

APOC3 encodes a protein that is involved in triglyceride homeostasis. It promotoes lipoprotein (VLDL1) assembly and secretion and helps hydrolysis of lipoprotein outside the cell (R).

It is associated with increased risk for high cholesterol (R).

Protein names

apolipoprotein C3 [Source:HGNC Symbol;Acc:HGNC:610]

Found in These Blog Articles

Is This Triglyceride Gene Related To Lifespan? (APOC3)

The APOC3 gene affects triglyceride levels in the body and may even be linked to longevity. Learn more about this gene here!

GHR Function

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.

More Information

From NCBI Gene: Hyperalphalipoproteinemia 2From UniProt: Hyperalphalipoproteinemia 2 (HALP2): A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. [MIM:614028]

From NCBI Gene: Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008] From UniProt: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.

Frequently Asked Questions

Why Are Alleles for This SNP Different Elsewhere? Major vs. Reference Allele Is My Variant Good or Bad? SNP vs. Mutation

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