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WDFY4
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs7072606 | |||
| rs2170132 | |||
| rs12268007 | |||
| rs41283281 | |||
| rs6537579 | |||
| rs11101459 | |||
| rs41283283 | |||
| rs539358549 | |||
| rs2377612 | |||
| rs2377613 | |||
| rs7097397 | |||
| rs11101460 | |||
| rs61742644 | |||
| rs10857644 | |||
| rs35423873 | |||
| rs11101500 | |||
| rs11101501 | |||
| rs1002196 | |||
| rs11101420 | |||
| rs144225791 |
Find on This Page
Summary
WDFY4 encodes WD repeat- and FYVE domain-containing protein 4. Variants of WDFY4 may play a role in rheumatoid arthritis by altering the function of immune cells.
Lifestyle, diet and supplement modifications may counteract the effects of these variants by supporting WDFY4 function and blocking autoimmune signalling.
Protein names
Found in These Blog Articles
More Information
The WDFY4 gene encodes a protein called WD repeat- and FYVE domain-containing protein 4. This protein is abundant in white blood cells and tissues that are important for the immune system, such as the lymph nodes, thymus, and spleen [R, R].
Very little is known about the WDFY4 protein except that it is expressed in the immune system and it requires zinc to function correctly [R].
Despite this mystery, multiple studies have found associations between WDFY4 variants and autoimmune conditions, including rheumatoid arthritis [R, R, R, R].
Researchers can only make informed guesses at the function of WDFY4 for the time being. Based on its structure and its abundance in immune tissues, some have speculated that it helps immune cells communicate with each other [R].
Systemic lupus erythematosus, another autoimmune disease, is believed to be associated with reduced WDFY4 expression. Because lupus and rheumatoid arthritis have similar mechanisms, it is likely that rheumatoid arthritis also has lower WDFY4 [R].
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