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UCP3
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs104894319 | |||
| rs45476292 | |||
| rs561891525 | |||
| rs769029996 | |||
| rs3781907 | |||
| rs1800006 | |||
| rs11235972 | |||
| rs1800849 | |||
| rs2075576 | |||
| rs1232548916 | |||
| rs1292739952 | |||
| rs142952570 | |||
| rs143786748 | |||
| rs145163696 | |||
| rs17848367 | |||
| rs17848372 | |||
| rs201948640 | |||
| rs2229707 | |||
| rs745890211 | |||
| rs74907838 |
Summary
The UCP3 gene encodes uncoupling protein 3. This protein sits on the mitochondrial membrane and is part of energy metabolism processes [R].
UCP3 helps keep your body at the right temperature. It signals for energy to be “burned” as heat rather than stored for use in cells. This process sounds inefficient, but it keeps you warm when it’s cold [R].
Variants in the UCP3 gene have been linked to [R, R]:
- High cholesterol
- High blood sugar
- Obesity
- Metabolic syndrome
Protein names
Found in These Blog Articles
GHR Function
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
More Information
From NCBI Gene: ObesityFrom UniProt: Obesity (OBESITY): A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. [MIM:601665]
From NCBI Gene: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008] From UniProt: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
Lifestyle & Supplement Interactions
Mice without PPAR alpha have 20X less UCP-3 (R).
How to Increase PPAR alpha:
- Cold (R),
- Exercise (R),
- Fasting (R) (R).
- Zinc (R)
- Fish oil/DHA (R),
- R-Lipoic Acid (R),
- Hydroxytyrosol (R),
- Resveratrol (R),
- Cinnamon (R),
- Epimedium/Icariin (R, R2),
- Nicotinamide Riboside/Niagen NAD+ (R).
- Oregano -carvacrol (R), Biochanin A (R)
- Carnitine (R),
- Naringenin (R)
- PQQ (R),
- Genistein (R),
- Palmitoylethanolamide (R)
- Lion's Mane (R)
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