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UCP2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs660339 | |||
| rs632862 | |||
| rs10535527 | |||
| rs1382219593 | |||
| rs45523540 | |||
| rs142467438 | |||
| rs45490393 | |||
| rs750166646 | |||
| rs769876535 | |||
| rs11235965 | |||
| rs77379755 | |||
| rs79758917 | |||
| rs1800006 | |||
| rs612914 | |||
| rs117567288 | |||
| rs590336 | |||
| rs2200614 | |||
| rs56282097 | |||
| rs34998602 | |||
| rs10898961 |
Summary
The UCP2 gene encodes uncoupling protein 2 [R].
UCP2 is found mostly in muscle tissues and helps the body produce heat without shivering. This protein creates “leaks” during the process of energy production in the mitochondria. This energy escapes as heat. Correct function of UCP2 also regulates insulin and protects against obesity and diabetes [R, R, R].
Variants in UCP2 have been linked to [R, R, R]:
- Non-alcoholic fatty liver disease
- Type 2 diabetes
- Obesity
Protein names
Found in These Blog Articles
GHR Function
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
More Information
UCP2 is found primarily in the muscle [R]. UCP2 plays a role in nonshivering heat creation by the body, reducing the risk of obesity [R] and diabetes [R].
UCP2 regulates insulin secretion [R]. During cellular respiration, UCP2 releases energy as heat [R]. UCP2 allows positively-charged ions to move from the inner to the outer mitochondrial membrane and protons to move from the outer to the inner mitochondrial membrane [R].
UCP2 pumps protons out of the cell membranes of mammals [R].
Covered on Genetics Home Reference: congenital hyperinsulinismFrom NCBI Gene: Body mass index quantitative trait locus 4
From NCBI Gene: Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008] From UniProt: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Lifestyle & Supplement Interactions
Cold exposure (cold showers) increases UCP2 [R].
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