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UBASH3A
SNP Table
Find on This Page
Summary
The UBASH3A gene helps block the activity of ZAP-70, a protein involved in activating NF-kB. A variant of UBASH3A may play a role in rheumatoid arthritis by dysregulating UBASH3A, increasing ZAP-70 activity, and promoting inflammation.
Lifestyle, diet, and supplement modifications may counteract the effects of this variant by suppressing ZAP-70 and/or NF-kB.
Protein names
Found in These Blog Articles
More Information
T cells are critical components of the immune system, able to detect foreign substances (such as bacteria) through receptors on their surfaces. Activation of T cells through these receptors normally promotes targeted immune responses necessary for the eradication of foreign substances [R, R].
Unfortunately, when T cell activity is dysregulated, immune responses may mistakenly be targeted toward the body’s own tissues. This is called autoimmunity [R].
The UBASH3A gene codes for ubiquitin-associated and SH3 domain-containing A (UBASH3A), an enzyme that suppresses T cell activity by blocking a protein called ZAP-70 [R, R, R, R].
ZAP-70 plays many roles in T cells, including the activation of inflammatory protein NF-kB [R, R].
Although this implies that a low amount of UBASH3A may result in inflammation, high amounts of this protein have also been linked to inflammation and autoimmunity — suggesting that an imbalance in UBASH3A may have deleterious effects [R, R].
Variants of UBASH3A have been associated with rheumatoid arthritis. These variants may dysregulate the production of UBASH3A, resulting in ZAP-70 activation and subsequent inflammation [R, R, R, R, R, R].
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