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STAT4
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1296987566 | |||
| rs200982266 | |||
| rs548245892 | |||
| rs771061948 | |||
| rs779115246 | |||
| rs1228274775 | |||
| rs35279173 | |||
| rs1198723307 | |||
| rs1337434431 | |||
| rs140675301 | |||
| rs3024839 | |||
| rs61756200 | |||
| rs780454944 | |||
| rs11440626 | |||
| rs141331848 | |||
| rs370218298 | |||
| rs762343259 | |||
| rs7572482 | |||
| rs7574070 | |||
| rs4853544 |
Summary
The STAT4 gene provides encodes a protein that acts as a transcription factor. The STAT4 protein is activated by cytokines, which are part of the inflammatory response to fight infection. It tells immune cells to get rid of foreign invaders in the cell (R).
Mutations of this gene can cause arthritis, lupus, and other autoimmune disorders (R).
Protein names
Found in These Blog Articles
GHR Function
The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. The STAT4 protein is turned on (activated) by immune system proteins called cytokines, which are part of the inflammatory response to fight infection. When activated, the STAT4 protein increases the activity of genes that help immune cells called T-cells mature into specialized T-cells. These specialized T-cells, called Th1 cells, produce specific cytokines and stimulate other immune cells to get rid of foreign invaders (pathogens) in the cell.
More Information
The STAT4 gene increases the activity of IL-12, IL-23, IFN-gamma, and other inflammatory proteins. These proteins stimulate the development of immature T helper cells into Th1 and Th17 cells [R].
Th1 and Th17 cells play a role in different inflammatory and autoimmune conditions, making STAT4 a promising candidate for the genetic background of lupus development [R, R].
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