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SPRED2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs934736 | |||
| rs2308100 | |||
| rs268133 | |||
| rs268137 | |||
| rs114625088 | |||
| rs114697110 | |||
| rs143086519 | |||
| rs111341502 | |||
| rs143706279 | |||
| rs187369371 | |||
| rs1876518 | |||
| rs2196606 | |||
| rs2217969 | |||
| rs2661792 | |||
| rs268130 | |||
| rs268132 | |||
| rs268140 | |||
| rs1194849 | |||
| rs268131 | |||
| rs6738087 |
Find on This Page
Summary
SPRED2 encodes a protein called sprouty related EVH1 domain containing 2. Variants of SPRED2 may play a role in rheumatoid arthritis through its effects on MAPK and the HPA axis.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by reducing HPA activity and regulating MAPK.
Protein names
Found in These Blog Articles
GHR Function
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
More Information
The SPRED2 gene encodes a protein called sprouty related EVH1 domain containing 2, part of a family of proteins that regulate the MAPK cascade [R].
Mitogen activated protein kinases (MAPKs) are a family of proteins that receive signals from outside the cell and translate them into messages for different parts of the cell machinery [R].
MAPKs are key parts of the cytokine-induced inflammatory response [R].
SPRED2 is also believed to reduce the activity of the HPA axis, which controls such vital functions as heart rate, blood pressure, and digestion [R, R].
The HPA axis also communicates with several regions of the brain, including [R]:
- The limbic system, which is implicated in motivation and mood,
- The amygdala, which generates fear in response to danger, and
- The hippocampus, which plays an important part in memory formation as well as in mood and motivation.
MAPK and the HPA axis are both closely linked to inflammation, and they have both been implicated in inflammatory disease [R, R, R, R].
Variants in the SPRED2 gene have been linked to a variety of seemingly unrelated conditions from dwarfism to rheumatoid arthritis [R, R].
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