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RAET1L
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs535925400 | |||
| rs76294770 | |||
| rs770170425 | |||
| rs117766916 | |||
| rs1276480314 | |||
| rs1288793002 | |||
| rs139983884 | |||
| rs141330153 | |||
| rs141345751 | |||
| rs145336297 | |||
| rs147287797 | |||
| rs148198102 | |||
| rs151268095 | |||
| rs1543547 | |||
| rs200401216 | |||
| rs201048549 | |||
| rs201121679 | |||
| rs369430003 | |||
| rs371585522 | |||
| rs372824469 |
Find on This Page
Summary
RAET1L encodes retinoic acid early transcript 1L. Variants of RAET1L may play a role in alopecia areata by interfering with the binding of NKG2D receptors.
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by promoting NK cell activity and preventing autoimmune inflammation.
Protein names
Found in These Blog Articles
More Information
The RAET1L gene (sometimes known as ULBP6) encodes retinoic acid early transcript 1L. This gene is part of the major histocompatibility complex (MHC), a group of genes that influence the immune response [R].
Major histocompatibility complex genes come in many different forms, and there are millions of their possible combinations. Their diversity ensures the protection against a wide array of external threats, but it can be a double-edged sword: some variants correlate with autoimmune and allergic disorders [R, R, R].
RAET1L may affect the immune response through interactions with a type of white blood cells called natural killer (NK) cells. When activated, NK cells target an invading cell—typically bacteria. Once an NK cell has engaged a target cell, RAET1L can bind to a receptor on its surface called NKG2D. This is the signal for the NK cell to kill its target [R].
Because of this close and direct relationship to NK cells, researchers have proposed using RAET1L as a drug target to modify the intensity of an immune response [R].
In alopecia areata, some research suggests that NK cells may have a protective function. One mouse study found that animals with lower NK cell counts lost more hair and had higher levels of a potentially destructive type of T cell [R].
NK cell activity also tends to be lower in autoimmune diseases like rheumatoid arthritis and lupus [R].
Two variants in the RAET1L gene have been associated with alopecia areata. The risk alleles of these variants may decrease the activity of NK cells in hair follicles [R, R].
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