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SelfDecode uses the only scientifically validated genetic prediction technology for consumers. Read more
PPARA
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs923691779 | |||
| rs135555 | |||
| rs1205309412 | |||
| rs142150973 | |||
| rs1800206 | |||
| rs1800234 | |||
| rs199553496 | |||
| rs200656207 | |||
| rs781206848 | |||
| rs1042311 | |||
| rs11381728 | |||
| rs13056623 | |||
| rs135571 | |||
| rs135574 | |||
| rs135577 | |||
| rs185169164 | |||
| rs201836521 | |||
| rs4823547 | |||
| rs4823550 | |||
| rs6007904 |
Summary
The PPARA gene encodes peroxisome proliferator activated receptor alpha (PPAR alpha), an important enzyme for metabolizing fat and glucose [R].
PPAR-alpha signals the liver to break down more fat. When you’re fasting and there aren’t enough carbs in your body to burn for energy, PPAR-alpha helps trigger ketogenesis, the process of burning fat for energy [R, R].
Variants in PPARA have been linked to [R, R, R, R]:
- Heart function at high altitude
- Headache at high altitude
- Drug side effects
- Cholesterol levels
Protein names
Found in These Blog Articles
More Information
May be required for the propagation of clock information to metabolic pathways regulated by PER2.
PPAR-a inhibits COX2 (R). PPAR-a can help increase IGF-1, which will help you build muscle. Mice without PPAR-alpha have 40% less IGF-1 (R). Mice without PPAR alpha have 20X less UCP-3 (R), which is important for fat loss. This and other mechanisms make PPAR alpha important for fat loss. PPAR-a causes insulin resistance in the liver (R).
Lifestyle & Supplement Interactions
Omega-6/Linoleic acid metabolites/Arachidonic acid, as well as other polyunsaturated fatty acids, are the main ways we naturally activate PPAR alpha (R). This is probably why omega-6's have some benefits in various studies.
It's good to get a good balance of DHA/EPA, MUFAs and Omega 6's, with some saturated fat (not excess like some paleo recommends). PPAR alpha is also stimulated by stress, cortisol, and insulin (R).
PPARa is activated by oleylethanolamide, a naturally occurring lipid that regulates satiety.
My favorite ways to increase PPAR-alpha:
- Cold (R)
- Exercise (R),
- Fasting (R) – fasting increases SIRT1 via activation of PPAR-alpha in mice (R).
- Fish oil/DHA (R),
- Hydroxytyrosol (R),
- Cinnamon (R)
Other ways to increase PPAR-alpha:
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