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PHRF1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs73398389 | |||
| rs370929509 | |||
| rs780085259 | |||
| rs11246212 | |||
| rs115674939 | |||
| rs936468 | |||
| rs12800061 | |||
| rs149443419 | |||
| rs201796525 | |||
| rs372878846 | |||
| rs375158487 | |||
| rs113700134 | |||
| rs11539530 | |||
| rs7928902 | |||
| rs113064640 | |||
| rs73398375 | |||
| rs114010389 | |||
| rs141010415 | |||
| rs151190592 | |||
| rs182144037 |
Find on This Page
Summary
PHRF1 can influence the production of interferon-alpha (IFN-alpha), a crucial inflammatory protein in lupus development. One PHRF1 gene variant has been associated with elevated IFN-alpha and higher lupus rates.
Simple dietary and lifestyle changes may prevent or improve lupus by targeting your gene variant.
Protein names
Found in These Blog Articles
More Information
Scientists are still investigating the exact roles of the PHRF1 gene. It likely plays a role in lupus by affecting another nearby gene, IRF7, which stimulates interferon-alpha (IFN-alpha) production [R, R].
IFN-alpha is an inflammatory protein with a central role in lupus development. Lupus patients tend to have elevated IFN-alpha, especially those with more active disease forms. They also have more active interferon-related genes, termed interferon signature [R, R, R].
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