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NQO1
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1800566 | |||
| rs1131341 | |||
| rs4985523 | |||
| rs12933210 | |||
| rs1837016 | |||
| rs2917670 | |||
| rs2917671 | |||
| rs45488899 | |||
| rs2917666 | |||
| rs2917678 | |||
| rs2965749 | |||
| rs55780735 | |||
| rs689455 | |||
| rs10048108 | |||
| rs1437135 | |||
| rs147094750 | |||
| rs2196574 | |||
| rs2361839 | |||
| rs57488237 | |||
| rs57964521 |
Summary
The NQO1 gene encodes an enzyme called NAD(P)H quinone oxidoreductase 1 [R].
NQO1 is an important antioxidant enzyme. It helps process toxins, carcinogens, and free radicals that cause oxidative stress [R].
NQO1 maintains levels of coenzyme Q10 (CoQ10), which in turn helps maintain mitochondrial function. CoQ10 prevents muscle degeneration, pain disorders, and other conditions. NQO1 also activates vitamin E and vitamin K [R, R, R].
Variants in NQO1 have been linked to [R, R, R]:
- Lung cancer
- Diabetes complications
- Prostate cancer
Protein names
Found in These Blog Articles
GHR Function
More Information
Read: About NQO1: A Critical Protein in Detoxing Drugs and Toxins.
NQO1 is an enzyme produced by the Nrf2 pathway that functions as an antioxidant, is important for detoxification and to increase NAD+ levels (R).
This protein enzymatic activity prevents the production of radical species and oxidative stress (R). NQO1 helps with stresses such as from polyaromatic toxins and carcinogens, or by helping break down superoxides and peroxides.
NQO1 directly scavenges superoxide (R). NQO1 is employed in the removal of a quinone from biological systems as a detoxification reaction: NAD(P)H + a quinone ’ NAD(P)+ + a hydroquinone (R).
Many of the hydroquinone products then get bound to glucuronides and sulfates and excreted (R).
NQO1 is concentrated in blood vessel tissue of mice, rats, and humans in order to deactivate toxins when they enter the blood stream (R).
NQO1 is important in activating vitamin K in order to allow it to function well, which allows for blood clotting, bone health and also anti-tumor properties (R). NQO1 changes ubiquinone to ubiquinol (R).
NQO1 increases the enzyme (Ornithine decarboxylase) for polyamine synthesis (like spermidine) (R). Polyamines like spermidine are anti-aging and healthful compounds. Low levels of NQO1 has been associated with (R):
- Many tumors “ individuals with decreased NQO1 expression/activity have reduced p53 stability. Several anti-tumor agents such as mitosenes, indolequinones, aziridinylbenzoquinones and ²-lapachone have been designed to be bioactivated by NQO1.
- Alzheimers disease
Since oxidative stress causes an inflammatory reaction, NQO1 ameliorates some animal models of autoimmune diseases (R).
The enzyme is involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
Lifestyle & Supplement Interactions
Melatonin can help detoxification by increasing NOQ1 (R), so make sure you’re keeping to your circadian rhythm or supplement.
Beta Lapachone, found in Pau Darco, potentiates and increases NQO1 activity in animal models. This results in increased energy expenditure as measured by oxygen consumption and heat generation (R). I notice an energy boosting effect from Pau Darco.
Thyroid hormones also help the detofification pathways and increase NQO1 (R).
Chlorogenic acid (R), which is found in coffee and plants increases NQO1. Carnosic acid, which is found in Rosemary and spices (R) increases NQO1.
Read my NRF2 post, because this is what controls gene production (R, R2). Anything that increases Nrf2 will increase NQO1. Oleanolic acid is a good way to increase NQO1 (R).
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