High Blood Sugar
Anxiety
Gluten Sensitivity
Gut Inflammation
Blood Pressure
IBS
Mood
Insomnia
PTSD
Mood Swings
Overweight
Memory Performance
Sexual Dysfunction
PCOS
Psoriasis
Joint Pain
Attention/ADHD
Chronic Fatigue / Tiredness
Allergies
Asthma
Acne
Tinnitus
Eczema
Food Allergy
Vitamin B6
Vitamin E
Restless Leg Syndrome
Grinding Teeth
Vitamin A
Magnesium
Zinc
Heart Health
Migraines
(High) Cholesterol
Headache
Chronic Pain
Back pain
Shoulder & Neck Pain
Stress
Inflammation
Omega-3 needs
Salt Sensitivity
Endurance
Power performance
Strength
Exercise recovery
Brain Fog
Female Fertility
Longevity
Addiction
Erectile Dysfunction
Male Infertility
MTHFR
Joint Inflammation
GERD
Ulcers
Sleep Apnea
Periodontitis
Varicose Veins
H. pylori
Liver Health
Canker Sores
Gallstones
Kidney Health
Gout
Hair Loss (Male-Pattern Baldness)
Riboflavin
Urticaria
Rosacea
Carpal Tunnel Syndrome
Sinus Congestion
Cavities
Artery Hardening
Vertigo
Vitiligo
Myopia
Indigestion
Excessive Sweating
Testosterone – Males
Yeast infection (Candida)
Endometriosis
Tobacco addiction
Alcohol addiction
Uterine fibroids
Length of menstrual cycle
UTI
OCD
Kidney Stones
Vitamin B12
Vitamin C
Vitamin D
Folate
Iron
Eating Disorders
Bone Health
Hypothyroidism
Hyperthyroidism
Sugar Cravings
Hearing/difficulty problem /Hearing loss
Painful Periods
Palpitations
Hemorrhoids
Hypotension
Bladder Control
Constipation
Appendicitis
Low Blood Sugar
Irregular Periods
Metabolic rate
Visceral fat
Lung Health
Anemia
Calcium
Cognition
Cognitive Decline
Seasonal Low Mood
Vitamin K
Phosphate
HRV
Cluster headaches
Knee Pain
Hip Pain
Selenium
Low back injury
Dyslexia
Cannabis addiction
Histamine Intolerance
Carnitine
Pesticide Sensitivity
Organophosphate Sensitivity
Cadmium
Lead
Melatonin
FSH
T4
T3
High PTH
Potassium
Coenzyme Q10 (CoQ10)
Chromium
Oxalate Sensitivity
Salicylate Sensitivity
Facial Wrinkles
Age Spots
Ligament Rupture (ACL Injury)
Tendon Injury (Tendinopathy)
Omega 6
Omega 6:Omega 3 Ratio
Arachidonic Acid
Oleic Acid
Alpha-Linolenic Acid
EPA
GLA
Linoleic Acid
DHA
Insulin Resistance
Sperm Motility
Homocysteine
C difficile
Pneumonia
EBV Infection
Gastrointestinal Infection
Chronic Bronchitis
Copper
Skin Elasticity
Skin Hydration
Egg allergy
ApoB
GGT
TIBC
Bioavailable Testosterone (Male)
MPV
Chloride
Free T4
Processing Speed
Short-term memory
TMAO
Air pollution sensitivity
Heart Rate
VO2 Max
Flu
Hair graying
Caffeine-Related Sleep Problems
Groin Hernia
Stretch marks
Droopy Eyelids
Strep infection
Dry eyes
Carbohydrate Consumption
Peanut allergy
Heart rate recovery
Muscle recovery
Jaw Disorders
HPV Infection
Acute Bronchitis
Chlamydia
Genital Herpes
Pancreas inflammation
Executive Function
Pyroglutamic acid
Raynaud’s
Liver Scarring
Dandruff
Bioavailable Testosterone (Female)
Shrimp allergy
Haptoglobin
Milk allergy
Beta-Alanine
Taurine
LDL Particle Size
Diarrhea
Snoring
Uric acid
Phenylalanine
Leucine
Glutamine
Valine
Glycine
Alanine
Lysine
Arginine
Histidine
Tyrosine
Cortisol
DHEAS
Insulin
Prolactin
TSH
Lactate
Ketone Bodies
IL-17A (Th17 Dominance)
Creatine Kinase
Neutrophils
Basophils
Eosinophils
Ferritin
ALT
AST
MCV
Hematocrit
RDW
SHBG
Total Protein
Albumin
MCH
Sodium
MCHC
Alkaline Phosphatase
Monocytes
Ghrelin
IL10 (Th2)
IL-6 (Th2 and Th17)
Iodine
Chili Pepper sensitivity
COMT
DRD2 (Dopamine)
Lectin Sensitivity
Thiamine
Biotin
Mold Sensitivity (Foodborne)
Chronic Lyme
BDNF
Glyphosate sensitivity
BPA Sensitivity
Pregnenolone
Luteinizing Hormone (LH)
Growth Hormone
IgA
Molybdenum
Sensitivity to Dairy (IgG Casein)
Telomere Length
Serotonin (5HIAA)
Non-Celiac Gluten Sensitivity (IgG Gliadin)
Manganese
Klotho
Mold Sensitivity (Airborne)
Amylase
Lipase
Low Sperm Count
Tryptophan
Methionine
Glutamate
Proline
Blood Calcium
Hypertriglyceridemia
HDL Cholesterol
HbA1c
Hemoglobin
Total Cholesterol
LDL Cholesterol
IGF1
Fasting Glucose
Bilirubin (total)
White blood cell count
Red blood cell count
Platelets
eGFR
Creatinine
Estradiol
Neuroticism
Sleep Quality
Lactose Intolerance
Saturated fat
Optimal diet
Unsaturated fat
Achilles tendon injury
Deep sleep
Fat
Response to Stress
Leadership
Ankle injury
Creativity
Hoarding
Protein
Optimal Exercise
Knee Injury
Rotator cuff injury
Extraversion
Risk-Taking
Happiness
Daytime Sleepiness
Morningness
Time spent watching TV
Disliking cilantro
Alcohol Sensitivity
Response to Caffeine
Snacking
Weight Regain
Sleep movement
Wearing glasses or contacts
Educational Attainment
Bitter Taste Sensitivity
Agreeableness
Aggression
Conscientiousness
Openness to experience
Physical activity
Caffeine-Related Anxiety
Naps
NFE2L2
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs139187151 | |||
| rs141363120 | |||
| rs181294188 | |||
| rs191231706 | |||
| rs200239262 | |||
| rs34154613 | |||
| rs35248500 | |||
| rs35577826 | |||
| rs60132461 | |||
| rs762411831 | |||
| rs17581525 | |||
| rs6721961 | |||
| rs34551701 | |||
| rs1025873873 | |||
| rs145293293 | |||
| rs147965728 | |||
| rs1806686 | |||
| rs191216619 | |||
| rs568251525 | |||
| rs78302770 |
Summary
Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a protein (transcription factor). Nrf2 increases the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
Substances that stimulate the Nrf2 pathway are being studied for the treatment of diseases that are caused by oxidative stress.
It responds to injury and inflammation [R].
Protein names
Found in These Blog Articles
GHR Function
More Information
Read: About NRF2 and Natural Ways to Increase It.
Nrf2 increases the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
————————————————————————————–
Nrf2 is found in the highest concentrations (in descending order) in the kidney, muscle, lung, heart, liver, and brain (R). Nrf2 stimulates NQO1, which donates electrons and detoxifies a variety of chemicals and drugs.
NQO1 is important for phase 2 detox. I suspect that people sensitive to everything have less NQO1 or less of an electron supply. Nrf2 produces two of the most important rate-limiting steps in glutathione (GSH) production.
Glutamate-cysteine ligase, catalytic (Gclc) and glutamate-cysteine ligase, modifier (GCLM) bind together to form glutathione. These are produced by Nrf2.
The glutathione S-transferase (GST) allow glutathione to bind with drugs and toxins, which then allow the body to eliminate potentially harmful and toxic compounds. GSTs are produced by Nrf2 activation and represent an important route of detoxification.
Sulfiredoxin 1 (SRXN1) and Thioredoxin reductase 1 (TXNRD1) give over electrons to peroxiredoxins, proteins important in the detoxification of hydrogen peroxide and peroxynitrite.
Nrf2 stimulates Heme oxygenase-1. Heme oxygenase-1 (HMOX1, HO-1) is an enzyme that catalyzes the breakdown of heme into the antioxidant biliverdin, the anti-inflammatory agent carbon monoxide, and iron. HO-1 defends against sepsis, hypertension, atherosclerosis, acute lung injury, kidney injury, and pain.
The UDP-glucuronosyltransferase (UGT) family catalyze the conjugation of a glucuronic acid to drugs, chemicals, and toxins, making them more water-soluble and readily excreted. Nrf2 has been shown to induce UGT1A1 and UGT1A6. Bilirubin and Tylenol are examples of substances that are glucuronidated.
My clients are more likely to have higher bilirubin and this can come from less of an ability to glucuronidation enzymes. Multidrug resistance-associated proteins (Mrps) are important membrane transporters that eject various compounds from various organs into bile or plasma, with subsequent excretion in the feces or urine, respectively. Mrps have been shown to be increased by Nrf2 and alteration in their expression can dramatically alter the pharmacokinetics and toxicity of compounds.
People with CIRS or biotoxin related issues usually have a problem excreting toxins in an efficient way and almost certainly the Nrf2 pathway will help excrete these toxins more easily. Reference.
The Negatives of Nrf2 Activation: Activation of NRF2 may promote the development of cancerous tumors. It can also contribute to the development of heart disease by raising cholesterol levels and cholesterol content in the liver. Having low cholesterol might be an indicator of less Nrf2 function (although there are many other pathways that lower cholesterol). Reference.
Frequently Asked Questions
Unlock Personalized Results And So Much More!
Shipping Worldwide
30-Days Money-Back Guarantee*
HSA/FSA Eligible
Essential Bundle
- 24/7 AI Health Coach
- 1250+ Comprehensive DNA Health Reports
- Personalized Diet, Supplement, & Lifestyle Recommendations
- Lifestyle Risk Assessments
- Unlimited access to Labs Analyzer
Men's Health Month 10% Off
Essential
Bundle
- Everything in essential
- SelfDecode DNA Kit
- Methylation Pathway
- +130 Medical Reports
- 25+ Longevity Screener Risk Assessments
- Odds ratios to evaluate your risk for 25+ medical conditions
- 10-year risk scores to prioritize health conditions
- Lifetime risk scores to plan for long-term health
Men's Health Month 15% Off
Men's Health Month 30% Off
Ultimate Bundle
- Everything in essential+
- SelfDecode DNA Kit
- Medication Check (PGx testing) for 50+ medications
- 40+ Family Planning (Carrier Status) Reports
- Ancestry Percentages
- Mitochondrial Ancestry
* SelfDecode DNA kits are non-refundable. If you choose to cancel your plan within 30 days you will not be refunded the cost of the kit.
We will never share your data
We follow HIPAA and GDPR policies
We have World-Class Encryption & Security
Rated 4.7/5 from 750+ reviews
200,000+ users, 2,000+ doctors & 80+ businesses
SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode strongly encourages those who use our service to consult and work with an experienced healthcare provider as our services are not to replace the relationship with a licensed doctor or regular medical screenings.