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MX2
SNP Table
Find on This Page
Summary
MX2 encodes MX dynamin like GTPase 2 or myxovirus resistance-2. Variants of MX2 may play a role in melanoma by altering the rate of growth and development of melanoma cells. It does not contain antiviral activity [R].
Lifestyle, diet, and supplement modifications may counteract the effects of these variants by regulating MX2 expression
Protein names
Found in These Blog Articles
More Information
The MX2 gene encodes MX dynamin like GTPase 2 (also known as myxovirus resistance-2), a protein that helps defend the body against infection by HIV and other similar viruses [R, R].
Interferon-alpha (IFN-alpha) is an immune response protein that recognizes viral infections and triggers an appropriate response. When IFN-alpha recognizes HIV (or other closely related viruses), it activates MX2. Researchers believe that MX2 then attacks the virus by either disrupting its genetic code or preventing it from inserting viral proteins into human cells [R].
More recently, MX2 has been implicated in cutaneous melanoma, the most deadly form of skin cancer [R, R].
The relationship between MX2 and melanoma appears complex. In most experimental melanomas, the most dangerous types of cells expressed lower levels of MX2. Furthermore, patients with high MX2 in their melanomas are more likely to live for longer. However, in some melanoma cells, the opposite is true. In both cases, researchers believe that MX2 is involved with the growth and division of the melanoma cells [R].
Interferons may be deficient in melanoma, and some researchers have even suggested directly administering interferons in melanoma patients [R, R].
According to one study, genetic variants that increase MX2 expression were associated with higher rates of melanoma development. This study further reinforces the complex relationship between this gene and melanoma [R].
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