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MICB
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs1051788 | |||
| rs1065075 | |||
| rs3134900 | |||
| rs41293883 | |||
| rs1065076 | |||
| rs2516474 | |||
| rs41293919 | |||
| rs2516484 | |||
| rs41293911 | |||
| rs41293915 | |||
| rs2534675 | |||
| rs2734583 | |||
| rs35405369 | |||
| rs9267485 | |||
| rs2534684 | |||
| rs2734576 | |||
| rs4959079 | |||
| rs9267461 | |||
| rs9267462 | |||
| rs9267463 |
Find on This Page
Summary
MICB belongs to the MHC or HLA group of genes, highly involved in lupus and other autoimmune conditions. The gene codes for a protein, MHC class I polypeptide-related sequence B. Specific gene variants may increase or alter MICB activity. They’ve been associated with higher odds of lupus. [R].
Protein names
Found in These Blog Articles
GHR Function
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
More Information
The MICB gene is closely related to the major histocompatibility complex (MHC) gene family, also known as the HLA system in humans. HLA proteins on the surface of white blood cells flag harmful external components and stimulate the immune response against them [R, R].
In people with lupus and other autoimmune conditions, HLA proteins may have increased activity or impaired structure. These changes cause them to target the body’s own components, such as skin & joints, and trigger inflammation [R].
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