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MICA
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs138201170 | |||
| rs41293539 | |||
| rs199503730 | |||
| rs67841474 | |||
| rs1051786 | |||
| rs1051792 | |||
| rs1051794 | |||
| rs1051798 | |||
| rs1051799 | |||
| rs1063630 | |||
| rs1063635 | |||
| rs1131898 | |||
| rs1140700 | |||
| rs41554412 | |||
| rs61738275 | |||
| rs9380254 | |||
| rs1051785 | |||
| rs1131896 | |||
| rs41558312 | |||
| rs3819268 |
Find on This Page
Summary
The gene codes for a protein, MHC class I polypeptide-related sequence A. Its role is as a stress-induced antigen. Variations are linked to psoriasis 1 and psoriatic arthritis [R].
Protein names
Found in These Blog Articles
GHR Function
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
More Information
Covered on Genetics Home Reference: autoimmune Addison diseaseidiopathic pulmonary fibrosisFrom UniProt: Psoriasis 1 (PSORS1): A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. [MIM:177900] Anti-MICA antibodies and ligand shedding are involved in the progression of monoclonal gammopathy of undetermined significance (MGUS)to multiple myeloma. Psoriatic arthritis (PSORAS): An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis). [MIM:607507]
From NCBI Gene: This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014] From UniProt: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
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