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LMX1A
SNP Table
| variant | genotype | frequency | risk allele |
|---|---|---|---|
| rs67130162 | |||
| rs141657804 | |||
| rs144980188 | |||
| rs10753675 | |||
| rs10918148 | |||
| rs1330390 | |||
| rs775094170 | |||
| rs144871103 | |||
| rs148227502 | |||
| rs10082152 | |||
| rs10800088 | |||
| rs1395548 | |||
| rs143117000 | |||
| rs1827328 | |||
| rs10800087 | |||
| rs5778442 | |||
| rs6426908 | |||
| rs1123821 | |||
| rs12125353 | |||
| rs12126669 |
Find on This Page
Summary
The LMX1A gene codes for a protein called LIM homeobox transcription factor 1-alpha. This gene and its protein play different roles at different stages of life.
In early development — meaning before birth, and during the first few months of life — the LMX1A gene stimulates the growth dopamine neurons in the developing brain [R, R, R].
In other words, how active this gene is when your brain is just starting to grow essentially determines how many dopamine neurons you will have later on in life!
Although its role in creating neurons is already finished by early childhood, LMX1A continues to play an important role throughout adulthood and later life by protecting your dopamine neurons from oxidative stress and mitochondrial dysfunction [R].
Therefore, the LMX1A gene is important for cognitive function because dopamine — and the neurons that produce and secrete it — are vital for several key aspects of cognitive function, such as working memory and cognitive flexibility [R, R].
SNPs in this gene, such as rs11809911, have been associated with performance on a wide variety of cognitive tests, including tests of learning and memory, cognitive flexibility (executive function and attention), processing speed, and even general intelligence (IQ) ('CC' = better, 'T' allele = poorer) [R].
To learn more about this gene and your genotypes for it, check out our SelfDecode Blog post on LMX1A!
>>> This gene is featured in SelfDecode's Cognitive Function DNA Wellness Report, along with 44 other key intelligence-related genes.
Protein names
Found in These Blog Articles
More Information
The LMX1A gene codes for a protein called LIM homeobox transcription factor 1-alpha. This gene and its protein play different roles at different stages of life.
In early development — meaning before birth, and during the first few months of life — the LMX1A gene stimulates the growth dopamine neurons in the developing brain [R, R, R].
In other words, how active this gene is when your brain is just starting to grow essentially determines how many dopamine neurons you will have later on in life!
Although its role in creating neurons is already finished by early childhood, LMX1A continues to play an important role throughout adulthood and later life by protecting your dopamine neurons from oxidative stress and mitochondrial dysfunction [R].
Therefore, the LMX1A gene is important for cognitive function because dopamine — and the neurons that produce and secrete it — are vital for several key aspects of cognitive function, such as working memory and cognitive flexibility [R, R].
SNPs in this gene, such as rs11809911, have been associated with performance on a wide variety of cognitive tests, including tests of learning and memory, cognitive flexibility (executive function and attention), processing speed, and even general intelligence (IQ) ('CC' = better, 'T' allele = poorer) [R].
To learn more about this gene and your genotypes for it, check out our SelfDecode Blog post on LMX1A!
>>> This gene is featured in SelfDecode's Cognitive Function DNA Wellness Report, along with 44 other key intelligence-related genes.
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